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This paper investigates the utilization of Large Language Models (LLMs) for solving complex linguistic puzzles, a domain requiring advanced reasoning and adept translation capabilities akin to human cognitive processes. We explore specific…

计算与语言 · 计算机科学 2025-02-04 Zheng-Lin Lin , Yu-Fei Shih , Shu-Kai Hsieh

Background: Identification of the interactions and regulatory relations between biomolecules play pivotal roles in understanding complex biological systems and the mechanisms underlying diverse biological functions. However, the collection…

计算与语言 · 计算机科学 2025-04-24 Gilchan Park , Byung-Jun Yoon , Xihaier Luo , Vanessa López-Marrero , Shinjae Yoo , Shantenu Jha

Large language models (LLMs) are having transformative impacts across a wide range of scientific fields, particularly in the biomedical sciences. Just as the goal of Natural Language Processing is to understand sequences of words, a major…

基因组学 · 定量生物学 2024-09-24 Gonzalo Benegas , Chengzhong Ye , Carlos Albors , Jianan Canal Li , Yun S. Song

Large Language Models (LLMs) have emerged as a transformative power in enhancing natural language comprehension, representing a significant stride toward artificial general intelligence. The application of LLMs extends beyond conventional…

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

计算与语言 · 计算机科学 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

Large language models (LLMs) demonstrate remarkable machine translation (MT) abilities via prompting, even though they were not explicitly trained for this task. However, even given the incredible quantities of data they are trained on,…

计算与语言 · 计算机科学 2023-02-16 Marjan Ghazvininejad , Hila Gonen , Luke Zettlemoyer

We investigate how to teach large language models (LLMs) to perform scientific reasoning by leveraging expert discussions as a learning signal. Focusing on the genomics domain, we develop an automated pipeline to extract trainable data and…

人工智能 · 计算机科学 2025-06-04 Ming Yin , Yuanhao Qu , Ling Yang , Le Cong , Mengdi Wang

Pretrained language models have served as important backbones for natural language processing. Recently, in-domain pretraining has been shown to benefit various domain-specific downstream tasks. In the biomedical domain, natural language…

计算与语言 · 计算机科学 2022-04-25 Hongyi Yuan , Zheng Yuan , Ruyi Gan , Jiaxing Zhang , Yutao Xie , Sheng Yu

Recent advances in large language models (LLMs) have made reasoning a central benchmark for evaluating intelligence. While prior surveys focus on efficiency by examining how to shorten reasoning chains or reduce computation, this view…

人工智能 · 计算机科学 2026-04-01 Chao Wu , Baoheng Li , Mingchen Gao , Yu Tian , Zhenyi Wang

Identifying DNA- (DBPs) and RNA-binding proteins (RBPs) is crucial for the understanding of cell function, molecular interactions as well as regulatory functions. Owing to their high similarity, most of the existing approaches face…

定量方法 · 定量生物学 2025-10-22 Nimisha Ghosh , Dheeran Sankaran , Rahul Balakrishnan Adhi , Sharath S , Amrut Anand

Large Language Models (LLMs) have revolutionized both general natural language processing and domain-specific applications such as code synthesis, legal reasoning, and finance. However, while prior studies have explored individual model…

软件工程 · 计算机科学 2025-12-05 Gunjan Das , Paheli Bhattacharya , Rishabh Gupta

Knowledge bases (KBs) contain plenty of structured world and commonsense knowledge. As such, they often complement distributional text-based information and facilitate various downstream tasks. Since their manual construction is resource-…

计算与语言 · 计算机科学 2022-03-10 Wenxuan Zhou , Fangyu Liu , Ivan Vulić , Nigel Collier , Muhao Chen

In recent years, large language models (LLMs) have achieved state-of-the-art results in various biological sequence analysis tasks, such as sequence classification, structure prediction, and function prediction. Similar to advancements in…

基因组学 · 定量生物学 2025-02-19 Wang Liang

While protein language models (pLMs) have transformed biological research, the scaling laws governing their improvement remain underexplored. By adapting methodologies from NLP scaling laws, we investigated the optimal ratio between model…

生物大分子 · 定量生物学 2024-06-27 Yaiza Serrano , Álvaro Ciudad , Alexis Molina

In this paper, we introduce LLMBridge, a new LLM based system for the task of end-to-end referential bridging resolution in English. Our bridging resolution pipeline combines heuristic pre/post-processing with the natural language inference…

计算与语言 · 计算机科学 2026-05-29 Lauren Levine , Amir Zeldes

Recent advances in natural language processing (NLP) owe their success to pre-training language models on large amounts of unstructured data. Still, there is an increasing effort to combine the unstructured nature of LMs with structured…

计算与语言 · 计算机科学 2023-12-22 Juraj Vladika , Alexander Fichtl , Florian Matthes

Large pretrained language models (PLMs) are often domain- or task-adapted via fine-tuning or prompting. Finetuning requires modifying all of the parameters and having enough data to avoid overfitting while prompting requires no training and…

计算与语言 · 计算机科学 2022-07-11 Zejiang Hou , Julian Salazar , George Polovets

Knowledge editing is a technique for efficiently and accurately updating the knowledge of large language models (LLMs) to alleviate obsolescence and correct errors. However, most existing methods overfit to specific models, causing edited…

人工智能 · 计算机科学 2025-03-05 Shuaike Li , Kai Zhang , Qi Liu , Enhong Chen

Domain-specific contextualized language models have demonstrated substantial effectiveness gains for domain-specific downstream tasks, like similarity matching, entity recognition or information retrieval. However successfully applying such…

计算与语言 · 计算机科学 2021-06-11 Sophia Althammer , Mark Buckley , Sebastian Hofstätter , Allan Hanbury

Recent advances in reasoning with large language models (LLMs) have demonstrated strong performance on complex mathematical tasks, including combinatorial optimization. Techniques such as Chain-of-Thought and In-Context Learning have…

人工智能 · 计算机科学 2025-09-17 Marylou Fauchard , Florian Carichon , Margarida Carvalho , Golnoosh Farnadi