相关论文: Influence of the Inhalation Route on Tracheal Flow…
Localized vortices can have significant influence on transport of inhaled particles through the upper respiratory tract. These vortices have complex three-dimensional structure with details dependent on the anatomical geometry. Using a…
Studies of flow through the human airway have shown that inhalation time (IT) and secondary flow structures can play important roles in particle deposition. However, the effects of varying IT in conjunction with respiratory rate (RR) on…
Accurate simulations of the flow in the human airway are essential for advancing diagnostic methods. Many existing computational studies rely on simplified geometries or turbulence models, limiting their simulation's ability to resolve flow…
Inhalation directs air through a defined pathway, initiating from nostrils, moving through the main nasal cavity, past the pharynx and trachea, and culminating in the lungs. Inhaled particles, of a range of sizes, are ferried by this…
Could the microdroplets formed by viscoelastic stretching and break-up of mucosal liquids in the upper respiratory tract (URT), when inhaled further downwind, explain the brisk pace at which deep lung infections emerge following onset of…
During a rapid inhalation, such as a sniff, the flow in the airways accelerates and decays quickly. The consequences for flow development and convective trans- port of an inhaled gas were investigated in a subject geometry extending from…
Investigations on airborne transmission of pathogens constitute a rapidly expanding field, primarily focused on understanding the expulsion patterns of respiratory particulates from infected hosts and their dispersion in confined spaces.…
Topological structure of bronchial trees affects transport of gases and aerosols in the respiratory system. We start by providing a quantitative assessment of the ability of the alternative tree representations to predict observable…
For the one billion sufferers of respiratory disease, managing their disease with inhalers crucially influences their quality of life. Generic treatment plans could be improved with the aid of computational models that account for…
The air flows in the proximal and distal portions of the human lungs are interconnected: the lower Reynolds number in the deeper generations causes a progressive flow regularization, while mass conservation requires flow rate oscillations…
The airflow in a subject-specific breathing human lung is simulated with a multiscale computational fluid dynamics (CFD) lung model. The three-dimensional (3D) airway geometry beginning from the mouth to about 7 generations of airways is…
We experimentally study the airflow in a collapsing cavity created by the impact of a circular disk on a water surface. We measure the air velocity in the collapsing neck in two ways: Directly, by means of employing particle image…
Inhalation drug delivery has seen a swift rise in the use of dry powder inhalers (DPIs) to treat chronic respiratory conditions. However, universal adoption of DPIs has been restrained due to their low efficiencies and significant drug…
Modeling of respiratory motion is important for a more accurate understanding and accounting of its effect on dose to cancers in the thorax and abdomen by radiotherapy. We have developed a model of respiration-induced organ motion in the…
In the presented study, a numerical model which predicts the flow-induced collapse within the pharyngeal airway is validated using in vitro measurements. Theoretical simplifications were considered to limit the computation time. Systematic…
The flow simulation in alveolar region is imperative in understanding transport of particles and designing aerosol drug delivery systems. Air flow is dependent on alveolar geometry and ventilation conditions. In this work a three…
Airflow through the nasal cavity exhibits a wide variety of fluid dynamicsbehaviour due to the intricacy of the nasal geometry. The flow is naturallyunsteady and perhaps turbulent, despite CFD in the literature that assumesa steady laminar…
Mesoscale filtering and protective layers are replete throughout the natural world. Within the body, arrays of extracellular proteins, microvilli, and cilia can act as both protective layers and mechanosensors. For example, blood flow…
The seemingly simple process of inhalation relies on a complex interplay between muscular contraction in the thorax, elasto-capillary interactions in individual lung branches, propagation of air between different connected branches, and…
Inspiratory and expiratory flow in a multi-generation pig lung airway was numerically studied at a peak tracheal flow rate corresponding to a Reynolds number of 1150. The model was validated by comparing velocity distributions with previous…