相关论文: Protein Circuit Tracing via Cross-layer Transcoder…

A plethora of protein language models have been released in recent years. Yet comparatively little work has addressed how to best sample from them to optimize desired biological properties. We fill this gap by proposing a flexible,…

Large Language Models (LLMs) have shown remarkable ability in solving complex tasks, making them a promising tool for enhancing tabular learning. However, existing LLM-based methods suffer from high resource requirements, suboptimal…

Protein language models (PLMs) have demonstrated remarkable capabilities in learning relationships between protein sequences and functions. However, finetuning these large models requires substantial computational resources, often with…

Comprehending the long-timescale dynamics of protein-ligand complexes is very important for drug discovery and structural biology, but it continues to be computationally challenging for large biomolecular systems. We introduce…

Mechanistic interpretability seeks to understand how Large Language Models (LLMs) represent and process information. Recent approaches based on dictionary learning and transcoders enable representing model computation in terms of sparse,…

Transformer-based vision-language models (VLMs) contain substantial depth redundancy, yet the effect of removing specific decoder layers remains poorly understood, especially for domains that require tight coupling between perception and…

Probabilistic Circuits (PCs) are deep generative models that support exact and efficient probabilistic inference. Yet in autoregressive language modeling, PCs still lag behind Transformer-based large language models (LLMs), suggesting an…

We present Pre-trained Machine Reader (PMR), a novel method for retrofitting pre-trained masked language models (MLMs) to pre-trained machine reading comprehension (MRC) models without acquiring labeled data. PMR can resolve the discrepancy…

Though the pre-trained contextualized language model (PrLM) has made a significant impact on NLP, training PrLMs in languages other than English can be impractical for two reasons: other languages often lack corpora sufficient for training…

Protein language models are a powerful tool for learning protein representations through pre-training on vast protein sequence datasets. However, traditional protein language models lack explicit structural supervision, despite its…

Printed electronics (PE) promises on-demand fabrication, low non-recurring engineering costs, and sub-cent fabrication costs. It also allows for high customization that would be infeasible in silicon, and bespoke architectures prevail to…

Recent advancements in computational chemistry have leveraged the power of trans-former-based language models, such as MoLFormer, pre-trained using a vast amount of simplified molecular-input line-entry system (SMILES) sequences, to…

Proteolysis targeting chimeras (PROTACs) are small molecules that trigger the breakdown of traditionally ``undruggable'' proteins by binding simultaneously to their targets and degradation-associated proteins. A key challenge in their…

Fine-tuning Pre-trained protein language models (PLMs) has emerged as a prominent strategy for enhancing downstream prediction tasks, often outperforming traditional supervised learning approaches. As a widely applied powerful technique in…

Recent advances in protein large language models, such as ProtTeX, represent both side-chain amino acids and backbone structure as discrete token sequences of residue length. While this design enables unified modeling of multimodal protein…

Less than 1% of protein sequences are structurally and functionally annotated. Natural Language Processing (NLP) community has recently embraced self-supervised learning as a powerful approach to learn representations from unlabeled text,…

Vision-language models are integral to computer vision research, yet many high-performing models remain closed-source, obscuring their data, design and training recipe. The research community has responded by using distillation from…

Protein language models (pLMs) have demonstrated success at generating functional proteins across vast sequence spaces but lack the ability to design high-fitness variants on demand. Here, we iteratively guide pLMs toward user-defined…

Free-text crash narratives recorded in real-world crash databases have been shown to play a significant role in improving traffic safety. However, large-scale analyses remain difficult to implement as there are no documented tools that can…

As Large Language Models (LLMs) continue to grow in size, storing and transmitting them on edge devices becomes increasingly challenging. Traditional methods like quantization and pruning struggle to achieve extreme compression of LLMs…