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Modelling gene regulatory networks not only requires a thorough understanding of the biological system depicted but also the ability to accurately represent this system from a mathematical perspective. Throughout this chapter, we aim to…

定量方法 · 定量生物学 2018-05-04 Olivia Angelin-Bonnet , Patrick J. Biggs , Matthieu Vignes

Large language models (LLMs) serve as an active and promising field of generative artificial intelligence and have demonstrated abilities to perform complex tasks in multiple domains, including mathematical and scientific reasoning. In this…

人工智能 · 计算机科学 2026-03-03 Ao Cheng , Lei Zhang , Guowei He

This paper presents an innovative large language model (LLM) agent framework for enhancing diagnostic accuracy in simulated clinical environments using the AgentClinic benchmark. The proposed automatic correction enables doctor agents to…

人工智能 · 计算机科学 2024-10-15 Abhishek Dutta , Yen-Che Hsiao

Time-inconsistent behavior, such as procrastination or abandonment of long-term goals, arises when agents evaluate immediate outcomes disproportionately higher than future ones. This leads to globally suboptimal behavior, where plans are…

计算机科学与博弈论 · 计算机科学 2026-01-13 Tatiana Belova , Yuriy Dementiev , Artur Ignatiev , Danil Sagunov

Power electronics, a critical component in modern power systems, face several challenges in control design, including model uncertainties, and lengthy and costly design cycles. This paper is aiming to propose a Large Language Models (LLMs)…

系统与控制 · 电气工程与系统科学 2024-06-19 Chenggang Cui , Jiaming Liu , Junkang Feng , Peifeng Hui , Amer M. Y. M. Ghias , Chuanlin Zhang

Document Question Answering (DocQA) is a very common task. Existing methods using Large Language Models (LLMs) or Large Vision Language Models (LVLMs) and Retrieval Augmented Generation (RAG) often prioritize information from a single…

机器学习 · 计算机科学 2025-03-19 Siwei Han , Peng Xia , Ruiyi Zhang , Tong Sun , Yun Li , Hongtu Zhu , Huaxiu Yao

Predicting how genetic perturbations change cellular state is a core problem for building controllable models of gene regulation. Perturbations targeting the same gene can produce different transcriptional responses depending on their…

基因组学 · 定量生物学 2026-02-12 Boyang Fu , George Dasoulas , Sameer Gabbita , Xiang Lin , Shanghua Gao , Xiaorui Su , Soumya Ghosh , Marinka Zitnik

Recent progress in multimodal graph neural networks has demonstrated that augmenting atomic XYZ geometries with textual chemical descriptors can enhance predictive accuracy across a range of electronic and thermodynamic properties. However,…

多智能体系统 · 计算机科学 2025-06-27 Can Polat , Mehmet Tuncel , Mustafa Kurban , Erchin Serpedin , Hasan Kurban

The arrival of Large Language Models (LLMs) has stirred up philosophical debates about the possibility of realizing agency in an artificial manner. In this work we contribute to the debate by presenting a theoretical model that can be used…

人工智能 · 计算机科学 2024-07-25 Maud van Lier , Gorka Muñoz-Gil

Social dilemmas are situations where groups of individuals can benefit from mutual cooperation but conflicting interests impede them from doing so. This type of situations resembles many of humanity's most critical challenges, and…

机器学习 · 计算机科学 2023-05-22 Manuel Rios , Nicanor Quijano , Luis Felipe Giraldo

The design of biological systems is hindered by uncertainty arising from both intrinsic stochasticity of biomolecular reactions and variability across laboratory or experimental conditions. In this work, we present a sequential framework to…

机器学习 · 计算机科学 2026-05-08 Michal Kobiela , Diego A. Oyarzún , Michael U. Gutmann

The evolution of large language models (LLMs) has enhanced the planning capabilities of language agents in diverse real-world scenarios. Despite these advancements, the potential of LLM-powered agents to comprehend ambiguous user…

计算与语言 · 计算机科学 2024-10-03 Xuan Zhang , Yang Deng , Zifeng Ren , See-Kiong Ng , Tat-Seng Chua

Traditional AI-based healthcare systems often rely on single-modal data, limiting diagnostic accuracy due to incomplete information. However, recent advancements in foundation models show promising potential for enhancing diagnosis…

人工智能 · 计算机科学 2025-03-24 Sihan Wang , Suiyang Jiang , Yibo Gao , Boming Wang , Shangqi Gao , Xiahai Zhuang

Table Question Answering (TableQA) enables natural language interaction with structured tabular data. However, existing large language model (LLM) approaches face critical limitations: context length constraints that restrict data handling…

人工智能 · 计算机科学 2026-03-11 Tong Wang , Chi Jin , Yongkang Chen , Huan Deng , Xiaohui Kuang , Gang Zhao

While Large Language Models (LLMs) have shown impressive capabilities in numerous Natural Language Processing (NLP) tasks, they still struggle with financial question answering (QA), particularly when numerical reasoning is required.…

计算与语言 · 计算机科学 2024-10-30 Sorouralsadat Fatemi , Yuheng Hu

The transcriptional response to genetic perturbation reveals fundamental insights into complex cellular systems. While current approaches have made progress in predicting genetic perturbation responses, they provide limited biological…

分子网络 · 定量生物学 2026-04-02 Yuanfang Xiang , Lun Ai

Radiology visual question answering (RVQA) provides precise answers to questions about chest X-ray images, alleviating radiologists' workload. While recent methods based on multimodal large language models (MLLMs) and retrieval-augmented…

人工智能 · 计算机科学 2025-08-06 Ziruo Yi , Jinyu Liu , Ting Xiao , Mark V. Albert

Defining agency is an extremely important challenge for cognitive science and artificial intelligence. Physics generally describes mechanical happenings, but there remains an unbridgeable gap between these and the acts of agents. To discuss…

系统与控制 · 电气工程与系统科学 2026-02-09 Yoshiyuki Ohmura , Earnest Kota Carr , Yasuo Kuniyoshi

Mathematical reasoning is a fundamental capability for large language models (LLMs), yet achieving high performance in this domain remains a significant challenge. The auto-regressive generation process often makes LLMs susceptible to…

人工智能 · 计算机科学 2024-12-02 Xiaoxuan Lou , Chaojie Wang , Bo An

Deciphering how DNA sequence encodes gene regulation remains a central challenge in biology. Advances in machine learning and functional genomics have enabled sequence-to-function (seq2func) models that predict molecular regulatory readouts…

基因组学 · 定量生物学 2026-02-03 Masayuki Nagai , Alan E. Murphy , Kaeli Rizzo , Peter K. Koo
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