相关论文: Protein Autoregressive Modeling via Multiscale Str…

Proteins are inherently multiscale physical systems whose functional properties emerge from coordinated structural organization across multiple spatial resolutions, ranging from atomic interactions to global fold topology. However, existing…

Recent advances in video generation have been dominated by diffusion and flow-matching models, which produce high-quality results but remain computationally intensive and difficult to scale. In this work, we introduce VideoAR, the first…

This work presents a generative modeling approach based on successive subspace learning (SSL). Unlike most generative models in the literature, our method does not utilize neural networks to analyze the underlying source distribution and…

Autoregressive (AR) models have demonstrated significant success in the realm of text-to-image generation. However, they usually face two major challenges. Firstly, the generated images may not always meet the quality standards expected by…

Generative models emerge as promising candidates for novel sequence-data driven approaches to protein design, and for the extraction of structural and functional information about proteins deeply hidden in rapidly growing sequence…

There exists recent work in computer vision, named VAR, that proposes a new autoregressive paradigm for image generation. Diverging from the vanilla next-token prediction, VAR structurally reformulates the image generation into a coarse to…

Autoregressive models have recently shown great promise in visual generation by leveraging discrete token sequences akin to language modeling. However, existing approaches often suffer from inefficiency, either due to token-by-token…

Visual Autoregressive Modeling (VAR) based on next-scale prediction achieves strong generation quality, but their explicit deep stacks fix the amount of computation per scale and inflate memory at high resolutions. We introduce Visual…

Autoregressive models have emerged as a powerful generative paradigm for visual generation. The current de-facto standard of next token prediction commonly operates over a single-scale sequence of dense image tokens, and is incapable of…

Recently, diffusion- and flow-based generative models of protein structures have emerged as a powerful tool for de novo protein design. Here, we develop Proteina, a new large-scale flow-based protein backbone generator that utilizes…

Coarse-grained molecular models of proteins permit access to length and time scales unattainable by all-atom models and the simulation of processes that occur on long-time scales such as aggregation and folding. The reduced resolution…

Graph generation has been dominated by autoregressive models due to their simplicity and effectiveness, despite their sensitivity to ordering. Yet diffusion models have garnered increasing attention, as they offer comparable performance…

Recent advances in generative modeling show that pretrained representations can improve generation as conditioning features or alignment targets. Motivated by this, we study protein representations for predicting structures beyond…

Visual Autoregressive (VAR) models have emerged as a powerful paradigm for image synthesis by performing hierarchical next-scale prediction. However, VAR models are inherently prone to cascading error propagation, where subtle coarse-scale…

Autoregressive (AR) models, the theoretical performance benchmark for learned lossless image compression, are often dismissed as impractical due to prohibitive computational cost. This work re-thinks this paradigm, introducing a framework…

Autoregressive models have demonstrated remarkable success in sequential data generation, particularly in NLP, but their extension to continuous-domain image generation presents significant challenges. Recent work, the masked autoregressive…

Decoder-only autoregressive image generation typically relies on fixed-length tokenization schemes whose token counts grow quadratically with resolution, substantially increasing the computational and memory demands of attention. We present…

Proteins are complex biomolecules that perform a variety of crucial functions within living organisms. Designing and generating novel proteins can pave the way for many future synthetic biology applications, including drug discovery.…

Protein inverse folding aims to design an amino acid sequence that will fold into a given backbone structure, serving as a central task in protein design. Two main paradigms have been widely explored. Template-based methods exploit…

Autoregressive (AR) image generators offer a language-model-friendly approach to image generation by predicting discrete image tokens in a causal sequence. However, unlike diffusion models, AR models lack a mechanism to refine previous…