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High-content perturbation experiments allow scientists to probe biomolecular systems at unprecedented resolution, but experimental and analysis costs pose significant barriers to widespread adoption. Machine learning has the potential to…

Large language models (LLMs) have shown potential in biomedical applications, leading to efforts to fine-tune them on domain-specific data. However, the effectiveness of this approach remains unclear. This study evaluates the performance of…

One third of stroke survivors have language difficulties. Emerging evidence suggests that their likelihood of recovery depends mainly on the damage to language centers. Thus previous research for predicting language recovery post-stroke has…

计算机视觉与模式识别 · 计算机科学 2018-11-28 Yusuf H. Roohani , Noor Sajid , Pranava Madhyastha , Cathy J. Price , Thomas M. H. Hope

Associative learning--forming links between co-occurring items--is fundamental to human cognition, reshaping internal representations in complex ways. Testing hypotheses on how representational changes occur in biological systems is…

机器学习 · 计算机科学 2025-10-27 Camila Kolling , Vy Ai Vo , Mariya Toneva

Behavioral simulation is increasingly used to anticipate responses to interventions. Large language models (LLMs) enable researchers to specify population characteristics and intervention context in natural language, but it remains unclear…

计算机与社会 · 计算机科学 2026-04-14 Zonghan Li , Feng Ji

Comprehensive evaluation of Large Language Models (LLMs) is an open research problem. Existing evaluations rely on deterministic point estimates generated via greedy decoding. However, we find that deterministic evaluations fail to capture…

机器学习 · 计算机科学 2025-03-04 Yan Scholten , Stephan Günnemann , Leo Schwinn

The clinical utility of deep learning models for medical image segmentation is severely constrained by their inability to generalize to unseen domains. This failure is often rooted in the models learning spurious correlations between…

计算机视觉与模式识别 · 计算机科学 2026-01-19 Tao Tang , Shijie Xu , Jionglong Su , Zhixiang Lu

The impressive linguistic abilities of large language models (LLMs) have recommended them as models of human sentence processing, with some conjecturing a positive 'quality-power' relationship (Wilcox et al., 2023), in which language…

计算与语言 · 计算机科学 2025-05-20 Yi-Chien Lin , Hongao Zhu , William Schuler

Large Language Models (LLMs) achieve strong performance through extended inference-time deliberation, yet how their reasoning failures arise remains poorly understood. By analyzing model-generated reasoning trajectories, we find that errors…

人工智能 · 计算机科学 2026-04-17 Wei Zhu , Jian Zhang , Lixing Yu , Kun Yue , Zhiwen Tang

Large language models (LLMs) are effective at capturing complex, valuable conceptual representations from textual data for a wide range of real-world applications. However, in fields like Intelligent Fault Diagnosis (IFD), incorporating…

人工智能 · 计算机科学 2024-12-03 Hamzah A. A. M. Qaid , Bo Zhang , Dan Li , See-Kiong Ng , Wei Li

Large language models (LLMs) have demonstrated remarkable capabilities in natural language understanding and task generalization. However, their application to structured data analysis remains fragile due to inconsistencies in schema…

人工智能 · 计算机科学 2025-05-06 Amit Rath

We propose a clinical decision support system (CDSS) for mental health diagnosis that combines the strengths of large language models (LLMs) and constraint logic programming (CLP). Having a CDSS is important because of the high complexity…

人工智能 · 计算机科学 2025-02-24 Brian Hyeongseok Kim , Chao Wang

Human daily behavior unfolds as complex sequences shaped by intentions, preferences, and context. Effectively modeling these behaviors is crucial for intelligent systems such as personal assistants and recommendation engines. While recent…

计算与语言 · 计算机科学 2026-04-28 Fanjin Meng , Jingtao Ding , Nian Li , Yizhou Sun , Yong Li

Large language models (LLMs) are increasingly used in social science simulations. While their performance on reasoning and optimization tasks has been extensively evaluated, less attention has been paid to their ability to simulate human…

计算工程、金融与科学 · 计算机科学 2025-08-25 Yuanjun Feng , Vivek Choudhary , Yash Raj Shrestha

Understanding a program's runtime reasoning behavior, meaning how intermediate states and control flows lead to final execution results, is essential for reliable code generation, debugging, and automated reasoning. Although large language…

软件工程 · 计算机科学 2025-12-02 Mohammad Abdollahi , Khandaker Rifah Tasnia , Soumit Kanti Saha , Jinqiu Yang , Song Wang , Hadi Hemmati

Human reasoning can be understood as a cooperation between the intuitive, associative "System-1" and the deliberative, logical "System-2". For existing System-1-like methods in visual activity understanding, it is crucial to integrate…

计算机视觉与模式识别 · 计算机科学 2023-11-30 Xiaoqian Wu , Yong-Lu Li , Jianhua Sun , Cewu Lu

To democratize large language models (LLMs) to most natural languages, it is imperative to make these models capable of understanding and generating texts in many languages, in particular low-resource ones. While recent multilingual LLMs…

计算与语言 · 计算机科学 2024-06-05 Wen Lai , Mohsen Mesgar , Alexander Fraser

The current work investigates the capability of Large language models (LLMs) that are explicitly trained on large corpuses of medical knowledge (Med-PaLM 2) to predict psychiatric functioning from patient interviews and clinical…

计算与语言 · 计算机科学 2023-08-04 Isaac R. Galatzer-Levy , Daniel McDuff , Vivek Natarajan , Alan Karthikesalingam , Matteo Malgaroli

Recent advances in multimodal large language models enable new possibilities for image-based decision support. However, their reliability and operational trade-offs in neuroimaging remain insufficiently understood. We present a…

Large language models (LLMs) have been widely used for mental health support. However, current safety evaluations in this field are mostly limited to detecting whether LLMs output prohibited words in single-turn conversations, neglecting…

计算与语言 · 计算机科学 2026-01-22 Youyou Cheng , Zhuangwei Kang , Kerry Jiang , Chenyu Sun , Qiyang Pan