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Ventricular Fibrillation (VF) is a malignant cardiac arrhythmia and the leading cause of sudden cardiac death, characterized by disorganized, high-frequency ventricular activity that results in the rapid loss of coordinated pump function…

生物物理 · 物理学 2025-11-04 Artemii Remizov , Sergey Lapin

Interest in the application of engineering methods to problems in congenital heart disease has gained increased popularity over the past decade. The use of computational simulation to examine common clinical problems including single…

医学物理 · 物理学 2011-01-20 Irene Vignon Clementel , Alison L. Marsden , Jeffrey A. Feinstein

- Modeling Human cardiovascular system is always an important issue. One of the most effective methods is using lumped model to reach to a complete model of human cardiovascular system. Such modeling with advanced considerations is used in…

Cardiovascular diseases (CVDs) are the leading causes of mortality worldwide. The contraction and relaxation of left ventricle (LV) is the main driving force of blood circulation. Altered LV hemodynamics is believed to be associated with…

医学物理 · 物理学 2019-11-04 Fanwei Kong , Christoph Augustin , Kevin Sack , Shawn Shadden

The circulatory system, comprising the heart and blood vessels, is vital for nutrient transport, waste removal, and homeostasis. Traditional computational models often treat cardiac electromechanics and blood flow dynamics separately,…

Computational fluid dynamics (CFD) models are emerging as tools for assisting in diagnostic assessment of cardiovascular disease. Recent advances in image segmentation has made subject-specific modelling of the cardiovascular system a…

Intracardiac flow patterns are shaped by the coupled motion of the cardiac chambers and heart valves and provide important information about cardiac function. However, clinical flow imaging remains limited by exam times, noise, resolution,…

图像与视频处理 · 电气工程与系统科学 2026-05-12 Fanwei Kong , Aaron Brown , Michael Loecher , Perry S. Choi , Lei Shi , Michael Ma , Daniel B. Ennis , Alison Marsden

The heart is the central part of the cardiovascular network. Its role is to pump blood to various body organs. Many cardiovascular diseases occur due to an abnormal functioning of the heart. A diseased heart leads to severe complications…

医学物理 · 物理学 2024-11-19 Mahesh S. Nagargoje , Eneko Lazpita , Jesús Garicano-Mena , Soledad Le Clainche

Image-based computational fluid dynamics (CFD) has emerged as a powerful tool to study cardiovascular flows while 2D echocardiography (echo) is the most widely used non-invasive imaging modality for diagnosis of heart disease. Here, echo is…

We propose a novel approach to generate samples from the conditional distribution of patient-specific cardiovascular models given a clinically aquired image volume. A convolutional neural network architecture with dropout layers is first…

定量方法 · 定量生物学 2021-09-01 Gabriel Maher , Casey Fleeter , Daniele Schiavazzi , Alison Marsden

Congenital heart disease (CHD) encompasses a spectrum of cardiovascular structural abnormalities, often requiring customized treatment plans for individual patients. Computational modeling and analysis of these unique cardiac anatomies can…

组织与器官 · 定量生物学 2023-11-09 Fanwei Kong , Sascha Stocker , Perry S. Choi , Michael Ma , Daniel B. Ennis , Alison Marsden

The availability of digital twins for the cardiovascular system will enable insightful computational tools both for research and clinical practice. This, however, demands robust and well defined models and methods for the different steps…

计算工程、金融与科学 · 计算机科学 2024-11-21 Pau Romero , Abel Pedrós , Rafael Sebastian , Miguel Lozano , Ignacio García-Fernández

We developed a novel patient-specific computational model for the numerical simulation of ventricular electromechanics in patients with ischemic cardiomyopathy (ICM). This model reproduces the activity both in sinus rhythm (SR) and in…

Deviations of the septal wall are widespread anatomic anomalies of the human nose; they vary significantly in shape and location, and often cause the obstruction of the nasal airways. When severe, septal deviations need to be surgically…

流体动力学 · 物理学 2024-05-14 Marcello Macellari , Andrea Schillaci , Umberto Tanzini , Matteo Trimarchi , Maurizio Quadrio

Computational hemodynamics is becoming an increasingly important tool in clinical applications and surgical procedures involving the cardiovascular system. Aim of this review is to provide a compact summary of state of the art 0D-1D…

医学物理 · 物理学 2022-01-03 Stefania Scarsoglio , Luca Ridolfi

Understanding the formation, propagation, and breakdown of the main vortex ring (VR) is essential for characterizing left ventricular (LV) hemodynamics, as its dynamics have been linked to the onset and progression of cardiovascular…

流体动力学 · 物理学 2025-07-30 Eneko Lazpita , Michael Neidlin , Jesus Garicano-Mena , Soledad Le Clainche

A cardiac digital twin is a virtual replica of a patient-specific heart, mimicking its anatomy and physiology. A crucial step of building a cardiac digital twin is anatomical twinning, where the computational mesh of the digital twin is…

Numerical simulations can model the physical processes that govern cardiovascular device deployment. When such simulations incorporate digital twins; computational models of patient-specific anatomy, they can expedite and de-risk the device…

计算机视觉与模式识别 · 计算机科学 2025-09-10 Karim Kadry , Shreya Gupta , Farhad R. Nezami , Elazer R. Edelman

Vascular remodelling is inherent to the pathogenesis of many diseases including cancer, neurodegeneration, fibrosis, hypertension, and diabetes. In this paper, a new susceptibility-contrast based MRI approach is established to analyse…

Statistical shape modeling (SSM) is a valuable and powerful tool to generate a detailed representation of complex anatomy that enables quantitative analysis and the comparison of shapes and their variations. SSM applies mathematics,…

图像与视频处理 · 电气工程与系统科学 2022-09-14 Krithika Iyer , Alan Morris , Brian Zenger , Karthik Karanth , Benjamin A Orkild , Oleksandre Korshak , Shireen Elhabian
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