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Genomic studies face a vast hypothesis space, while interventions such as gene perturbations remain costly and time-consuming. To accelerate such experiments, gene perturbation models predict the transcriptional outcome of interventions.…

定量方法 · 定量生物学 2025-10-21 George Panagopoulos , Johannes F. Lutzeyer , Sofiane Ennadir , Michalis Vazirgiannis , Jun Pang

We introduce LatentTimePFN (LaT-PFN), a foundational Time Series model with a strong embedding space that enables zero-shot forecasting. To achieve this, we perform in-context learning in latent space utilizing a novel integration of the…

机器学习 · 计算机科学 2024-05-24 Stijn Verdenius , Andrea Zerio , Roy L. M. Wang

TabPFN has recently gained attention as a foundation model for tabular datasets, achieving strong performance by leveraging in-context learning on synthetic data. However, we find that TabPFN is vulnerable to label shift, often overfitting…

机器学习 · 计算机科学 2026-05-26 Seunghan Lee

Modeling event sequences of multiple event types with marked temporal point processes (MTPPs) provides a principled way to uncover governing dynamical rules and predict future events. Current neural network approaches to MTPP inference rely…

机器学习 · 计算机科学 2026-03-02 David Berghaus , Patrick Seifner , Kostadin Cvejoski , César Ojeda , Ramsés J. Sánchez

Tabular foundation models based on pretrained prior-data fitted networks~(PFNs) have shown strong generalization on diverse tabular tasks, but they are typically designed for \emph{non-strategic} settings where data distributions are…

The human brain is the gold standard of adaptive learning. It not only can learn and benefit from experience, but also can adapt to new situations. In contrast, deep neural networks only learn one sophisticated but fixed mapping from inputs…

计算机视觉与模式识别 · 计算机科学 2021-03-18 Shixian Wen , Amanda Rios , Yunhao Ge , Laurent Itti

Building Virtual Cells that can accurately simulate cellular responses to perturbations is a long-standing goal in systems biology. A fundamental challenge is that high-throughput single-cell sequencing is destructive: the same cell cannot…

机器学习 · 计算机科学 2026-02-24 Xinyu Yuan , Xixian Liu , Ya Shi Zhang , Zuobai Zhang , Hongyu Guo , Jian Tang

The diversity of time series applications and scarcity of domain-specific data highlight the need for time-series models with strong few-shot learning capabilities. In this work, we propose a novel training scheme and a transformer-based…

机器学习 · 计算机科学 2025-02-25 Ege Onur Taga , M. Emrullah Ildiz , Samet Oymak

Causal structure learning (CSL) refers to the task of learning causal relationships from data. Advances in CSL now allow learning of causal graphs in diverse application domains, which has the potential to facilitate data-driven causal…

机器学习 · 统计学 2024-07-09 Luka Kovačević , Izzy Newsham , Sach Mukherjee , John Whittaker

Causal discovery is fundamental for multiple scientific domains, yet extracting causal information from real world data remains a significant challenge. Given the recent success on real data, we investigate whether TabPFN, a…

机器学习 · 计算机科学 2025-11-11 Omar Swelam , Lennart Purucker , Jake Robertson , Hanne Raum , Joschka Boedecker , Frank Hutter

Hollmann et al. (Nature 637 (2025) 319-326) recently introduced TabPFN, a transformer-based deep learning model for regression and classification on tabular data, which they claim "outperforms all previous methods on datasets with up to…

机器学习 · 计算机科学 2025-12-01 Qiong Zhang , Yan Shuo Tan , Qinglong Tian , Pengfei Li

Networks (graphs) in psychology are often restricted to settings without interventions. Here we consider a framework borrowed from biology that involves multiple interventions from different contexts (observations and experiments) in a…

统计方法学 · 统计学 2024-09-23 Lourens Waldorp , Jolanda Kossakowski , Han L. J. van der Maas

Causal inference, estimating causal effects from observational data, is a fundamental tool in many disciplines. Of particular importance across a variety of domains is the continuous treatment setting, where the variable of intervention has…

机器学习 · 计算机科学 2026-05-15 Christopher Stith , Medha Barath , Vahid Balazadeh , Jesse C. Cresswell , Rahul G. Krishnan

TabPFN [Hollmann et al., 2023], a Transformer model pretrained to perform in-context learning on fresh tabular classification problems, was presented at the last ICLR conference. To better understand its behavior, we treat it as a black-box…

机器学习 · 计算机科学 2025-02-14 Calvin McCarter

In drug discovery, mapping interactions between genes within cellular systems is a crucial early step. Such maps are not only foundational for understanding the molecular mechanisms underlying disease biology but also pivotal for…

Identifying variables responsible for changes to a biological system enables applications in drug target discovery and cell engineering. Given a pair of observational and interventional datasets, the goal is to isolate the subset of…

机器学习 · 计算机科学 2025-06-02 Menghua Wu , Umesh Padia , Sean H. Murphy , Regina Barzilay , Tommi Jaakkola

Traditional methods for tabular classification usually rely on supervised learning from scratch, which requires extensive training data to determine model parameters. However, a novel approach called Prior-Data Fitted Networks (TabPFN) has…

机器学习 · 计算机科学 2024-06-12 Quangao Liu , Wei Yang , Chen Liang , Longlong Pang , Zhuozhang Zou

In engineering design, navigating complex decision-making landscapes demands a thorough exploration of the design, performance, and constraint spaces, often impeded by resource-intensive simulations. Data-driven methods can mitigate this…

计算工程、金融与科学 · 计算机科学 2024-01-17 Cyril Picard , Faez Ahmed

State-of-the-art data stream mining has long drawn from ensembles of the Very Fast Decision Tree, a seminal algorithm honored with the 2015 KDD Test-of-Time Award. However, the emergence of large tabular models, i.e., transformers designed…

机器学习 · 计算机科学 2025-12-16 Afonso Lourenço , João Gama , Eric P. Xing , Goreti Marreiros

Tabular classification has traditionally relied on supervised algorithms, which estimate the parameters of a prediction model using its training data. Recently, Prior-Data Fitted Networks (PFNs) such as TabPFN have successfully learned to…

机器学习 · 计算机科学 2023-11-20 Benjamin Feuer , Chinmay Hegde , Niv Cohen