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Structural magnetic resonance imaging (MRI) studies have shown that Alzheimer's Disease (AD) induces both localised and widespread neural degenerative changes throughout the brain. However, the absence of segmentation that highlights brain…

图像与视频处理 · 电气工程与系统科学 2024-06-21 Chen Zheng

Accurate and early diagnosis of Alzheimer's disease (AD) is critical for effective intervention and requires integrating complementary information from multimodal neuroimaging data. However, conventional fusion approaches often rely on…

Deep learning is attracting significant interest in the neuroimaging community as a means to diagnose psychiatric and neurological disorders from structural magnetic resonance images. However, there is a tendency amongst researchers to…

机器学习 · 计算机科学 2019-10-22 David Wood , James Cole , Thomas Booth

Deep learning has shown outstanding performance in identifying intricate structures in complex high-dimensional data, especially in the domain of computer vision. The application of deep learning to early detection and automated…

图像与视频处理 · 电气工程与系统科学 2019-08-22 Taeho Jo , Kwangsik Nho , Andrew J. Saykin

Significant progress has been made using fMRI to characterize the brain changes that occur in ASD, a complex neuro-developmental disorder. However, due to the high dimensionality and low signal-to-noise ratio of fMRI, embedding informative…

图像与视频处理 · 电气工程与系统科学 2019-08-15 Xiaoxiao Li , Nicha C. Dvornek , Juntang Zhuang , Pamela Ventola , James Duncan

Alzheimer's disease (AD) is the leading cause of dementia, and its early detection is crucial for effective intervention, yet current diagnostic methods often fall short in sensitivity and specificity. This study aims to detect significant…

图像与视频处理 · 电气工程与系统科学 2024-11-01 Milla E. Nielsen , Mads Nielsen , Mostafa Mehdipour Ghazi

Alzheimer's disease (AD) is the most prevalent form of dementia, and its early diagnosis is essential for slowing disease progression. Recent studies on multimodal neuroimaging fusion using MRI and PET have achieved promising results by…

计算机视觉与模式识别 · 计算机科学 2025-11-05 Delin Ma , Menghui Zhou , Jun Qi , Yun Yang , Po Yang

Early and accurate diagnosis of Alzheimer Disease is critical for effective clinical intervention, particularly in distinguishing it from Mild Cognitive Impairment, a prodromal stage marked by subtle structural changes. In this study, we…

图像与视频处理 · 电气工程与系统科学 2025-10-08 Fahad Mostafa , Kannon Hossain , Hafiz Khan

Volume change measures derived from longitudinal MRI (e.g. hippocampal atrophy) are a well-studied biomarker of disease progression in Alzheimer's Disease (AD) and are used in clinical trials to track the therapeutic efficacy of…

Medical imaging datasets are inherently high dimensional with large variability and low sample sizes that limit the effectiveness of deep learning algorithms. Recently, generative adversarial networks (GANs) with the ability to synthesize…

图像与视频处理 · 电气工程与系统科学 2024-12-13 Apoorva Sikka , Skand Peri , Jitender Singh Virk , Usma Niyaz , Deepti R. Bathula

Alzheimer's Dementia (AD) is a progressive neurodegenerative disease marked by irreversible decline, making reliable modeling of its progression essential for effective patient care. Progression-aware methods such as survival analysis are…

Age-Related Macular Degeneration (AMD) is an asymptomatic retinal disease which may result in loss of vision. There is limited access to high-quality relevant retinal images and poor understanding of the features defining sub-classes of…

计算机视觉与模式识别 · 计算机科学 2019-02-13 Yi-Chieh Liu , Hao-Hsiang Yang , Chao-Han Huck Yang , Jia-Hong Huang , Meng Tian , Hiromasa Morikawa , Yi-Chang James Tsai , Jesper Tegner

In this paper, we introduce a novel normative modeling approach that incorporates focal loss and adversarial autoencoders (FAAE) for Alzheimer's Disease (AD) diagnosis and biomarker identification. Our method is an end-to-end approach that…

图像与视频处理 · 电气工程与系统科学 2024-11-19 Songlin Zhao , Rong Zhou , Yu Zhang , Yong Chen , Lifang He

The aging population of the U.S. drives the prevalence of Alzheimer's disease. Brookmeyer et al. forecasts approximately 15 million Americans will have either clinical AD or mild cognitive impairment by 2060. In response to this urgent…

图像与视频处理 · 电气工程与系统科学 2023-12-01 Long Chen , Liben Chen , Binfeng Xu , Wenxin Zhang , Narges Razavian

Structural MRI and PET imaging play an important role in the diagnosis of Alzheimer's disease (AD), showing the morphological changes and glucose metabolism changes in the brain respectively. The manifestations in the brain image of some…

图像与视频处理 · 电气工程与系统科学 2023-08-11 Yanteng Zhang , Qizhi Teng , Xiaohai He , Tong Niu , Lipei Zhang , Yan Liu , Chao Ren

Dementia and especially Alzheimer's disease (AD) are the most common causes of cognitive decline in elderly people. A spread of the above mentioned mental health problems in aging societies is causing a significant medical and economic…

神经元与认知 · 定量生物学 2018-12-03 Tomasz M. Rutkowski , Qibin Zhao , Masao S. Abe , Mihoko Otake

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease; yet its currently available treatments are limited to stopping disease progression. Moreover, effectiveness of these treatments is not guaranteed due to the…

机器学习 · 计算机科学 2024-02-02 Diego Machado Reyes , Hanqing Chao , Juergen Hahn , Li Shen , Pingkun Yan

For effective treatment of Alzheimer disease (AD), it is important to identify subjects who are most likely to exhibit rapid cognitive decline. Herein, we developed a novel framework based on a deep convolutional neural network which can…

计算机视觉与模式识别 · 计算机科学 2017-04-21 Hongyoon Choi , Kyong Hwan Jin

Previous works in the literature apply 3D spatial-only models on 4D functional MRI data leading to possible sub-par feature extraction to be used for downstream tasks like classification. In this work, we aim to develop a novel 4D…

图像与视频处理 · 电气工程与系统科学 2025-06-04 Javier Salazar Cavazos , Scott Peltier