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Protein-protein interaction (PPI) extraction from published scientific literature provides additional support for precision medicine efforts. Meanwhile, knowledge bases (KBs) contain huge amounts of structured information of protein…

计算与语言 · 计算机科学 2019-12-12 Huiwei Zhou , Xuefei Li , Weihong Yao , Zhuang Liu , Shixian Ning , Chengkun Lang , Lei Du

Medical image interpretation using deep learning has shown promise but often requires extensive expert-annotated datasets. To reduce this annotation burden, we develop an Image-Graph Contrastive Learning framework that pairs chest X-rays…

图像与视频处理 · 电气工程与系统科学 2024-05-17 Sameer Khanna , Daniel Michael , Marinka Zitnik , Pranav Rajpurkar

Graphs are a powerful tool for representing and analyzing unstructured, non-Euclidean data ubiquitous in the healthcare domain. Two prominent examples are molecule property prediction and brain connectome analysis. Importantly, recent works…

机器学习 · 计算机科学 2022-04-04 Kamilia Mullakaeva , Luca Cosmo , Anees Kazi , Seyed-Ahmad Ahmadi , Nassir Navab , Michael M. Bronstein

Recent work on predicting patient outcomes in the Intensive Care Unit (ICU) has focused heavily on the physiological time series data, largely ignoring sparse data such as diagnoses and medications. When they are included, they are usually…

机器学习 · 计算机科学 2021-01-12 Emma Rocheteau , Catherine Tong , Petar Veličković , Nicholas Lane , Pietro Liò

Existing research usually utilizes side information such as social network or item attributes to improve the performance of collaborative filtering-based recommender systems. In this paper, the knowledge graph with user perception is used…

信息检索 · 计算机科学 2022-10-10 Yuyao Zeng , Junping Du , Zhe Xue , Ang Li

Knowledge based dialogue systems have attracted increasing research interest in diverse applications. However, for disease diagnosis, the widely used knowledge graph is hard to represent the symptom-symptom relations and symptom-disease…

计算与语言 · 计算机科学 2020-12-29 Xinyan Zhao , Liangwei Chen , Huanhuan Chen

Clinical evidence encompasses the associations and impacts between patients, interventions (such as drugs or physiotherapy), problems, and outcomes. The goal of recommending clinical evidence is to provide medical practitioners with…

计算与语言 · 计算机科学 2023-04-05 Maolin Luo , Xiang Zhang

Here we present a holistic approach for data exploration on dense knowledge graphs as a novel approach with a proof-of-concept in biomedical research. Knowledge graphs are increasingly becoming a vital factor in knowledge mining and…

人工智能 · 计算机科学 2019-12-16 Jens Dörpinghaus , Alexander Apke , Vanessa Lage-Rupprecht , Andreas Stefan

Predicting molecule-protein interactions (MPIs) is a fundamental task in computational biology, with crucial applications in drug discovery and molecular function annotation. However, existing MPI models face two major challenges. First,…

机器学习 · 计算机科学 2025-12-11 Jiayu Qin , Zhengquan Luo , Guy Tadmor , Changyou Chen , David Zeevi , Zhiqiang Xu

Recent years have witnessed the fast development of large-scale pre-training frameworks that can extract multi-modal representations in a unified form and achieve promising performances when transferred to downstream tasks. Nevertheless,…

计算机视觉与模式识别 · 计算机科学 2022-10-18 Xuran Pan , Tianzhu Ye , Dongchen Han , Shiji Song , Gao Huang

In recent years, knowledge graphs have been integrated into recommender systems as item-side auxiliary information, enhancing recommendation accuracy. However, constructing and integrating structural user-side knowledge remains a…

信息检索 · 计算机科学 2024-12-19 Zheng Hu , Zhe Li , Ziyun Jiao , Satoshi Nakagawa , Jiawen Deng , Shimin Cai , Tao Zhou , Fuji Ren

Imaging-derived phenotypes (IDPs) summarize multi-organ physiology but provide only static snapshots of diseases that evolve over time. In contrast, longitudinal electronic health records encode disease trajectories through temporal…

Generative paradigm, especially powered by Large Language Models (LLMs), has emerged as a new solution to the next point-of-interest (POI) recommendation. Pioneering studies usually adopt a two-stage pipeline, starting with a tokenizer…

信息检索 · 计算机科学 2025-09-17 Ke Sun , Mayi Xu

In the era of increasingly complex AI models for time series forecasting, progress is often measured by marginal improvements on benchmark leaderboards. However, this approach suffers from a fundamental flaw: standard evaluation metrics…

机器学习 · 计算机科学 2026-05-28 Wanjin Feng , Yuan Yuan , Jingtao Ding , Yong Li

In this work, we propose a novel goal-oriented dialog task, automatic symptom detection. We build a system that can interact with patients through dialog to detect and collect clinical symptoms automatically, which can save a doctor's time…

计算与语言 · 计算机科学 2021-01-26 Hongyin Luo , Shang-Wen Li , James Glass

Medical text learning has recently emerged as a promising area to improve healthcare due to the wide adoption of electronic health record (EHR) systems. The complexity of the medical text such as diverse length, mixed text types, and full…

计算与语言 · 计算机科学 2022-10-11 Yong He , Cheng Wang , Shun Zhang , Nan Li , Zhaorong Li , Zhenyu Zeng

Addressing the challenges related to data sparsity, cold-start problems, and diversity in recommendation systems is both crucial and demanding. Many current solutions leverage knowledge graphs to tackle these issues by combining both…

Protein-protein interaction (PPI) extraction from published scientific literature provides additional support for precision medicine efforts. However, many of the current PPI extraction methods need extensive feature engineering and cannot…

计算与语言 · 计算机科学 2020-01-08 Huiwei Zhou , Zhuang Liu1 , Shixian Ning , Chengkun Lang , Yingyu Lin , Lei Du

While pioneering deep learning methods have made great strides in analyzing electronic health record (EHR) data, they often struggle to fully capture the semantics of diverse medical codes from limited data. The integration of external…

机器学习 · 计算机科学 2024-08-26 Zhihao Yu , Yujie Jin , Yongxin Xu , Xu Chu , Yasha Wang , Junfeng Zhao

The use of narratives as a means of fusing information from knowledge graphs (KGs) into a coherent line of argumentation has been the subject of recent investigation. Narratives are especially useful in event-centric knowledge graphs in…

数据库 · 计算机科学 2025-04-23 Florian Plötzky , Katarina Britz , Wolf-Tilo Balke