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The advent of ultra-high dose rate irradiation, known as FLASH radiation therapy, has shown promising potential in reducing toxicity while maintaining tumor control. However, the clinical translation of these benefits necessitates efficient…

医学物理 · 物理学 2024-09-19 Viktor Wase , Oscar Widenfalk , Rasmus Nilsson , Claes Fälth , Albin Fredriksson

This paper describes a micro fluorescence in situ hybridization ({\mu}FISH)-based rapid detection of cytogenetic biomarkers on formalin-fixed paraffin embedded (FFPE) tissue sections. We demonstrated this method in the context of detecting…

组织与器官 · 定量生物学 2018-06-19 Deborah Huber , Govind V. Kaigala

Over almost five decades of development and improvement, Magnetic Resonance Imaging (MRI) has become a rich and powerful, non-invasive technique in medical imaging, yet not reaching its physical limits. Technical and physiological…

Spatial dependence in the statistics of redshifted 21cm fluctuations promises to provide the most powerful probe of the reionisation epoch. In this paper we consider the second and third moments of the redshifted 21cm intensity distribution…

天体物理学 · 物理学 2015-06-24 Stuart Wyithe , Miguel Morales

We developed a new magnetic resonance imaging method called multinuclear fingerprinting (MNF) which leverages simultaneously-acquired proton (1H) and sodium (23Na) data to generate seven quantitative maps of the whole brain: proton density…

Accurate identification of charged pions and kaons is essential for precision measurements in relativistic heavy-ion collisions, but becomes increasingly challenging at intermediate and high transverse momentum due to the overlap between…

仪器与探测器 · 物理学 2026-03-05 Shaowei Lan , Bijun Fan , Like Liu

Electromagnetic decoupling among a close-fitting or high-density transceiver RF array elements is required to maintain the integrity of the magnetic flux density from individual channel for enhanced performance in detection sensitivity and…

医学物理 · 物理学 2022-11-23 Komlan Payne , Leslie L. Ying , Xiaoliang Zhang

Purpose: To verify dose delivery and quality assurance of volumetric modulated arc therapy (VMAT) for head and neck cancer. Method: The Imaging and Radiation Oncology Core Houston (IROC-H) head and neck phantom with thermo- luminescent…

Purpose: To evaluate the feasibility of a 3-minute b-tensor encoding protocol for diffusion MRI-based assessment of the microscopic anisotropy and tissue heterogeneity in a wide range of intracranial tumors. Methods: B-tensor encoding was…

Biological tissue imaging by secondary ion mass spectrometry has seen rapid development with the commercial availability of polyatomic primary ion sources. Endogenous lipids and other small bio-molecules can now be routinely mapped on the…

The efficiency of a proton exchange membrane (PEM) fuel cell depends on the mobility of protons in the PEM, which is determined by the hydration and temperature of the membrane. While optical techniques or neutron or x-ray scattering…

材料科学 · 物理学 2023-01-10 Darshan Chalise , Shreyan Majumdar , David G. Cahill

This research paper presents a novel approach to the prediction of hypoxia in brain tumors, using multi-parametric Magnetic Resonance Imaging (MRI). Hypoxia, a condition characterized by low oxygen levels, is a common feature of malignant…

图像与视频处理 · 电气工程与系统科学 2024-01-26 Daniele Perlo , Georgia Kanli , Selma Boudissa , Olivier Keunen

Advanced radiotherapy approaches such as FLASH irradiation and spatially fractionated radiotherapy (SFRT) show potential to improve the therapeutic ratio, yet their biological mechanisms and optimal delivery parameters remain uncertain.…

Improving the coincidence time resolution (CTR) of time-of-flight positron emission tomography (TOF-PET) systems to achieve a higher signal-to-noise ratio (SNR) gain or even direct positron emission imaging (dPEI) is of paramount importance…

Spectro-ptychography offers improved spatial resolution and additional phase spectral information relative to that provided by scanning transmission X-ray microscopes (STXM). However, carrying out ptychography at the lower range of soft…

Background: Magnetization transfer (MT) saturation reflects the additional saturation of the MRI signal imposed by an MT pulse and is largely driven by the saturation of the bound pool. This reduction of the bound polarization by the MT…

医学物理 · 物理学 2021-05-03 Gunther Helms , Nikolaus Weiskopf , Antoine Lutti

Purpose: Mechanical thrombectomy (MT) improves stroke outcomes, but is limited by a lack of local treatment access. Widespread distribution of reinforcement learning (RL)-based robotic systems can be used to alleviate this challenge through…

Minibeam and microbeam radiation therapy promise improved treatment outcomes through reduced normal tissue toxicity at better tumor control rates. The lack of suitable compact radiation sources limits the clinical application of minibeams…

We present a magnet and high power electronics for Prepolarized Magnetic Resonance Imaging (PMRI) in a home-made, special-purpose preclinical system designed for simultaneous visualization of hard and soft biological tissues. PMRI boosts…

Purpose: This study aims to develop a high-resolution whole-brain multi-parametric quantitative MRI approach for simultaneous mapping of myelin-water fraction (MWF), T1, T2, and proton-density (PD), all within a clinically feasible scan…