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Clinical trial eligibility matching is a critical yet often labor-intensive and error-prone step in medical research, as it ensures that participants meet precise criteria for safe and reliable study outcomes. Recent advances in Natural…

机器学习 · 计算机科学 2025-03-04 Muhammad Talha Sharif , Abdul Rehman

Objective: The generalizability of clinical large language models is usually ignored during the model development process. This study evaluated the generalizability of BERT-based clinical NLP models across different clinical settings…

计算与语言 · 计算机科学 2023-03-16 Sicheng Zhou , Nan Wang , Liwei Wang , Ju Sun , Anne Blaes , Hongfang Liu , Rui Zhang

Clinical trials need to recruit a sufficient number of volunteer patients to demonstrate the statistical power of the treatment (e.g., a new drug) in curing a certain disease. Clinical trial recruitment has a significant impact on trial…

机器学习 · 计算机科学 2024-07-19 Ling Yue , Sixue Xing , Jintai Chen , Tianfan Fu

Clinical trial outcome prediction seeks to estimate the likelihood that a clinical trial will successfully reach its intended endpoint. This process predominantly involves the development of machine learning models that utilize a variety of…

生物大分子 · 定量生物学 2024-05-14 Chufan Gao , Tianfan Fu , Jimeng Sun

This study evaluated the effect of BioBERT in medical text processing for the task of medical named entity recognition. Through comparative experiments with models such as BERT, ClinicalBERT, SciBERT, and BlueBERT, the results showed that…

计算与语言 · 计算机科学 2024-12-12 Jiacheng Hu , Runyuan Bao , Yang Lin , Hanchao Zhang , Yanlin Xiang

Objective: Fluoropyrimidines are widely prescribed for colorectal and breast cancers, but are associated with toxicities such as hand-foot syndrome and cardiotoxicity. Since toxicity documentation is often embedded in clinical notes, we…

计算与语言 · 计算机科学 2025-10-24 Xizhi Wu , Madeline S. Kreider , Philip E. Empey , Chenyu Li , Yanshan Wang

The objective of this study is to develop natural language processing (NLP) models that can analyze patients' drug reviews and accurately classify their satisfaction levels as positive, neutral, or negative. Such models would reduce the…

计算与语言 · 计算机科学 2023-08-09 Yue Ling

Natural language processing (NLP) of clinical trial documents can be useful in new trial design. Here we identify entity types relevant to clinical trial design and propose a framework called CT-BERT for information extraction from clinical…

定量方法 · 定量生物学 2021-10-20 Xiong Liu , Greg L. Hersch , Iya Khalil , Murthy Devarakonda

The introduction of Large Language Models (LLMs), and the vast volume of publicly available medical data, amplified the application of NLP to the medical domain. However, LLMs are pretrained on data that are not explicitly relevant to the…

计算与语言 · 计算机科学 2023-12-12 Chris Solomou

Obtaining large-scale annotated data for NLP tasks in the scientific domain is challenging and expensive. We release SciBERT, a pretrained language model based on BERT (Devlin et al., 2018) to address the lack of high-quality, large-scale…

计算与语言 · 计算机科学 2019-09-12 Iz Beltagy , Kyle Lo , Arman Cohan

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

计算与语言 · 计算机科学 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

The exponential increase in scientific literature and online information necessitates efficient methods for extracting knowledge from textual data. Natural language processing (NLP) plays a crucial role in addressing this challenge,…

计算与语言 · 计算机科学 2025-10-22 Zhyar Rzgar K. Rostam , Gábor Kertész

The rising rate of drug-related deaths in the United States, largely driven by fentanyl, requires timely and accurate surveillance. However, critical overdose data are often buried in free-text coroner reports, leading to delays and…

The practice of fine-tuning Pre-trained Language Models (PLMs) from general or domain-specific data to a specific task with limited resources, has gained popularity within the field of natural language processing (NLP). In this work, we…

计算与语言 · 计算机科学 2023-10-31 Samuel Belkadi , Lifeng Han , Yuping Wu , Goran Nenadic

Despite advances in machine learning (ML) and large language models (LLMs), rule-based natural language processing (NLP) systems remain active in clinical settings due to their interpretability and operational efficiency. However, their…

计算与语言 · 计算机科学 2025-06-23 Jianlin Shi , Brian T. Bucher

Many promising-looking ideas in AI research fail to deliver, but their validation takes substantial human labor and compute. Predicting an idea's chance of success is thus crucial for accelerating empirical AI research, a skill that even…

人工智能 · 计算机科学 2025-06-03 Jiaxin Wen , Chenglei Si , Yueh-han Chen , He He , Shi Feng

Introduction: Clinical text classification using natural language processing (NLP) models requires adequate training data to achieve optimal performance. For that, 200-500 documents are typically annotated. The number is constrained by time…

The prediction of learning curves for Natural Language Processing (NLP) models enables informed decision-making to meet specific performance objectives, while reducing computational overhead and lowering the costs associated with dataset…

机器学习 · 计算机科学 2025-10-21 Viktoria Schram , Markus Hiller , Daniel Beck , Trevor Cohn

Misdiagnosis rates are one of the leading causes of medical errors in hospitals, affecting over 12 million adults across the US. To address the high rate of misdiagnosis, this study utilizes 4 NLP-based algorithms to determine the…

机器学习 · 计算机科学 2022-06-29 Krish Maniar , Shafin Haque , Kabir Ramzan

Efficient text classification is essential for handling the increasing volume of academic publications. This study explores the use of pre-trained language models (PLMs), including BERT, SciBERT, BioBERT, and BlueBERT, fine-tuned on the Web…

计算与语言 · 计算机科学 2025-09-09 Zhyar Rzgar K Rostam , Gábor Kertész
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