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Causal inference methods are widely applied in various decision-making domains such as precision medicine, optimal policy and economics. Central to causal inference is the treatment effect estimation of intervention strategies, such as…

人工智能 · 计算机科学 2021-05-31 Tri Dung Duong , Qian Li , Guandong Xu

State-of-the-art clustering algorithms use heuristics to partition the feature space and provide little insight into the rationale for cluster membership, limiting their interpretability. In healthcare applications, the latter poses a…

机器学习 · 统计学 2018-12-04 Dimitris Bertsimas , Agni Orfanoudaki , Holly Wiberg

There is strong interest in estimating how the magnitude of treatment effects of an intervention vary across sub-groups of the population of interest. In our paper, we propose a two-study approach to first propose and then test…

统计方法学 · 统计学 2020-06-23 Rahul Ladhania , Amelia Haviland , Neeraj Sood , Edward Kennedy , Ateev Mehrotra

Decision tree learning is a widely used approach in machine learning, favoured in applications that require concise and interpretable models. Heuristic methods are traditionally used to quickly produce models with reasonably high accuracy.…

Linear structural causal models (SCMs) -- in which each observed variable is generated by a subset of the other observed variables as well as a subset of the exogenous sources -- are pervasive in causal inference and casual discovery.…

机器学习 · 计算机科学 2022-11-09 Yuqin Yang , Mohamed Nafea , AmirEmad Ghassami , Negar Kiyavash

Accurately assessing a patient's risk of a given event is essential in making informed treatment decisions. One approach is to stratify patients into two or more distinct risk groups with respect to a specific outcome using both clinical…

统计方法学 · 统计学 2015-03-17 Karen Lostritto , Robert Strawderman , Annette Molinaro

Decision tree learning is increasingly being used for pointwise inference. Important applications include causal heterogenous treatment effects and dynamic policy decisions, as well as conditional quantile regression and design of…

机器学习 · 统计学 2024-02-08 Matias D. Cattaneo , Jason M. Klusowski , Peter M. Tian

This study proposes a novel framework based on the RuleFit method to estimate Heterogeneous Treatment Effect (HTE) in a randomized clinical trial. To achieve this, we adopted S-learner of the metaalgorithm for our proposed framework. The…

统计方法学 · 统计学 2023-07-28 Mayu Hiraishi , Ke Wan , Kensuke Tanioka , Hiroshi Yadohisa , Toshio Shimokawa

Identifying subgroups, which respond differently to a treatment, both in terms of efficacy and safety, is an important part of drug development. A well-known challenge in exploratory subgroup analyses is the small sample size in the…

统计计算 · 统计学 2016-06-28 Marius Thomas , Björn Bornkamp

Cluster-randomized trials (CRTs) are widely used to evaluate group-level interventions and increasingly collect multiple outcomes capturing complementary dimensions of benefit and risk. Investigators often seek a single global summary of…

统计方法学 · 统计学 2026-01-22 Xinyuan Chen , Fan Li

We formulate a general framework for building structural causal models (SCMs) with deep learning components. The proposed approach employs normalising flows and variational inference to enable tractable inference of exogenous noise…

机器学习 · 统计学 2020-10-26 Nick Pawlowski , Daniel C. Castro , Ben Glocker

In many applications, it is important to identify subpopulations that survive longer or shorter than the rest of the population. In medicine, for example, it allows determining which patients benefit from treatment, and in predictive…

机器学习 · 计算机科学 2026-02-26 Mhd Jawad Al Rahwanji , Sascha Xu , Nils Philipp Walter , Jilles Vreeken

In biomedical Subgroup Discovery, practitioners are interested in discovering interpretable and homogeneous subgroups within a group of patients. In this paper, assuming that healthy subjects (i.e., controls) share common but irrelevant…

机器学习 · 计算机科学 2026-05-21 Robin Louiset , Edouard Duchesnay , Benoit Dufumier , Antoine Grigis , Pietro Gori

Clinical predictive algorithms are increasingly being used to form the basis for optimal treatment policies--that is, to enable interventions to be targeted to the patients who will presumably benefit most. Despite taking advantage of…

Understanding and inferencing Heterogeneous Treatment Effects (HTE) and Conditional Average Treatment Effects (CATE) are vital for developing personalized treatment recommendations. Many state-of-the-art approaches achieve inspiring…

机器学习 · 计算机科学 2024-08-28 Chan Hsu , Jun-Ting Wu , Yihuang Kang

Recent research in causal inference has made important progress in addressing challenges to the external validity of trial findings. Such methods weight trial participant data to more closely resemble the distribution of effect-modifying…

统计方法学 · 统计学 2024-07-18 Justin M. Clark , Kollin W. Rott , James S. Hodges , Jared D. Huling

To perform counterfactual reasoning in Structural Causal Models (SCMs), one needs to know the causal mechanisms, which provide factorizations of conditional distributions into noise sources and deterministic functions mapping realizations…

机器学习 · 计算机科学 2021-11-16 Guy Lorberbom , Daniel D. Johnson , Chris J. Maddison , Daniel Tarlow , Tamir Hazan

Decision-making across various fields, such as medicine, heavily relies on conditional average treatment effects (CATEs). Practitioners commonly make decisions by checking whether the estimated CATE is positive, even though the…

We address a core problem in causal inference: estimating heterogeneous treatment effects using panel data with general treatment patterns. Many existing methods either do not utilize the potential underlying structure in panel data or have…

机器学习 · 统计学 2024-06-11 Retsef Levi , Elisabeth Paulson , Georgia Perakis , Emily Zhang

We consider a dynamic model for competition in a social network, where two strategic agents have fixed beliefs and the non-strategic/regular agents adjust their states according to a distributed consensus protocol. We suppose that one…

社会与信息网络 · 计算机科学 2021-05-06 M. Bini , P. Frasca , C. Ravazzi , F. Dabbene