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We consider planning longitudinal covariate measurements in follow-up studies where covariates are time-varying. We assume that the entire cohort cannot be selected for longitudinal measurements due to financial limitations and study how a…

统计方法学 · 统计学 2024-07-03 Jaakko Reinikainen , Juha Karvanen

Bayesian hyperparameter optimization relies heavily on Gaussian Process (GP) surrogates, due to robust distributional posteriors and strong performance on limited training samples. GPs however underperform in categorical hyperparameter…

机器学习 · 计算机科学 2025-09-23 Riccardo Doyle

Conditional Neural Processes (CNP; Garnelo et al., 2018) are an attractive family of meta-learning models which produce well-calibrated predictions, enable fast inference at test time, and are trainable via a simple maximum likelihood…

机器学习 · 计算机科学 2021-10-19 Stratis Markou , James Requeima , Wessel Bruinsma , Richard Turner

In oncology, conduct well-powered time-to-event randomized clinical trials may be challenging due to limited patietns number. Many designs for single-arm trials (SATs) have recently emerged as an alternative to overcome this issue. They…

应用统计 · 统计学 2026-04-10 Chloé Szurewsky , Guosheng Yin , Gwénaël Le Teuff

In complex and unknown processes, global models are initially generated over the entire experimental space but often fail to provide accurate predictions in local areas. A common approach is to use local models, which requires partitioning…

机器学习 · 计算机科学 2025-05-29 Dominik Polke , Tim Kösters , Elmar Ahle , Dirk Söffker

Causal discovery algorithms often perform poorly with limited samples. While integrating expert knowledge (including from LLMs) as constraints promises to improve performance, guarantees for existing methods require perfect predictions or…

Datasets that exhibit non-Gaussian characteristics are common in many fields, while the current modeling framework and available software for non-Gaussian models is limited. We introduce Linear Latent Non-Gaussian Models (LLnGMs), a unified…

统计方法学 · 统计学 2026-03-02 David Bolin , Xiaotian Jin , Alexandre B. Simas , Jonas Wallin

Sequential decision-making algorithms such as multi-armed bandits can find optimal personalized decisions, but are notoriously sample-hungry. In personalized medicine, for example, training a bandit from scratch for every patient is…

机器学习 · 计算机科学 2026-05-12 Ahmet Zahid Balcıoğlu , Newton Mwai , Emil Carlsson , Fredrik D. Johansson

Participant recruitment based on unstructured medical texts such as clinical notes and radiology reports has been a challenging yet important task for the cohort establishment in clinical research. Recently, Large Language Models (LLMs)…

计算与语言 · 计算机科学 2023-07-24 Zihan Guan , Zihao Wu , Zhengliang Liu , Dufan Wu , Hui Ren , Quanzheng Li , Xiang Li , Ninghao Liu

We investigate joint modeling of longevity trends using the spatial statistical framework of Gaussian Process regression. Our analysis is motivated by the Human Mortality Database (HMD) that provides unified raw mortality tables for nearly…

应用统计 · 统计学 2020-03-06 Nhan Huynh , Mike Ludkovski

We develop a novel measurement framework based on a Gaussian process coregionalization model to address a long-lasting debate in psychometrics: whether psychological features like personality share a common structure across the population,…

机器学习 · 计算机科学 2024-07-09 Yehu Chen , Muchen Xi , Jacob Montgomery , Joshua Jackson , Roman Garnett

Accurate and reliable forecasting of epidemic incidences is critical for public health preparedness, yet it remains a challenging task due to complex nonlinear temporal dependencies and heterogeneous spatial interactions. Often, point…

机器学习 · 统计学 2026-03-10 Rajdeep Pathak , Tanujit Chakraborty

Motivated by the pressing need for suicide prevention through improving behavioral healthcare, we use medical claims data to study the risk of subsequent suicide attempts for patients who were hospitalized due to suicide attempts and later…

应用统计 · 统计学 2023-05-09 Wenjie Wang , Chongliang Luo , Robert H. Aseltine , Fei Wang , Jun Yan , Kun Chen

Suicidal ideation detection is critical for real-time suicide prevention, yet its progress faces two under-explored challenges: limited language coverage and unreliable annotation practices. Most available datasets are in English, but even…

计算与语言 · 计算机科学 2025-07-22 Amina Dzafic , Merve Kavut , Ulya Bayram

Gaussian Processes are widely used for regression tasks. A known limitation in the application of Gaussian Processes to regression tasks is that the computation of the solution requires performing a matrix inversion. The solution also…

机器学习 · 计算机科学 2017-08-22 Sourish Das , Sasanka Roy , Rajiv Sambasivan

Composite endpoints that combine multiple outcomes on different scales are common in clinical trials, particularly in chronic conditions. In many of these cases, patients will have to cross a predefined responder threshold in each of the…

统计方法学 · 统计学 2019-02-20 Martina McMenamin , Jessica K. Barrett , Anna Berglind , James M. S. Wason

Statistical analysis of microbiome data is challenging. Bayesian multinomial logistic-normal (MLN) models have gained popularity due to their ability to account for the count compositional nature of these data, but existing approaches are…

统计方法学 · 统计学 2025-05-27 Tinghua Chen , Michelle Pistner Nixon , Justin D. Silverman

More than one million people commit suicide every year worldwide. The costs of daily cares, social stigma and treatment issues are still hard barriers to overcome in mental health. Most symptoms of mental disorders are related to the…

For data with high-dimensional covariates but small to moderate sample sizes, the analysis of single datasets often generates unsatisfactory results. The integrative analysis of multiple independent datasets provides an effective way of…

统计方法学 · 统计学 2015-01-19 Yuan Huang , Qingzhao Zhang , Sanguo Zhang , Jian Huang , Shuangge Ma

Some scenarios require the computation of a predictive distribution of a new value evaluated on an objective function conditioned on previous observations. We are interested on using a model that makes valid assumptions on the objective…

机器学习 · 计算机科学 2021-01-21 Lucia Asencio-Martín , Eduardo C. Garrido-Merchán