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Linear models are widely used in computational neuroimaging to identify biomarkers associated with brain pathologies. However, interpreting the learned weights remains challenging, as they do not always yield clinically meaningful insights.…

机器学习 · 计算机科学 2026-04-23 Sara Petiton , Antoine Grigis , Raphaël Vock , Edouard Duchesnay

Human brains exhibit highly organized multiscale neurophysiological dynamics. Understanding those dynamic changes and the neuronal networks involved is critical for understanding how the brain functions in health and disease. Functional…

神经元与认知 · 定量生物学 2024-09-09 Manuel Morante , Kristian Frølich , Naveed ur Rehman

Functional MRI is a neuroimaging technique that analyzes the functional activity of the brain by measuring blood-oxygen-level-dependent signals throughout the brain. The derived functional features can be used for investigating brain…

神经元与认知 · 定量生物学 2026-02-16 Giorgio Dolci , Silvia Saglia , Lorenza Brusini , Vince D. Calhoun , Ilaria Boscolo Galazzo , Gloria Menegaz

Functional connectivity, as estimated using resting state fMRI, has shown potential in bridging the gap between pathophysiology and cognition. However, clinical use of functional connectivity biomarkers is impeded by unreliable estimates of…

In neuroscience, understanding inter-individual differences has recently emerged as a major challenge, for which functional magnetic resonance imaging (fMRI) has proven invaluable. For this, neuroscientists rely on basic methods such as…

计算机视觉与模式识别 · 计算机科学 2020-04-07 Akrem Sellami , François-Xavier Dupé , Bastien Cagna , Hachem Kadri , Stéphane Ayache , Thierry Artières , Sylvain Takerkart

Functional magnetic resonance imaging (fMRI) data is characterized by its complexity and high--dimensionality, encompassing signals from various regions of interests (ROIs) that exhibit intricate correlations. Analyzing fMRI data directly…

应用统计 · 统计学 2024-01-18 Yeseul Jeon , Jeong-Jae Kim , SuMin Yu , Junggu Choi , Sanghoon Han

We analyze functional magnetic resonance imaging (fMRI) data from the Human Connectome Project (HCP) to match brain activities during a range of cognitive tasks. Our findings demonstrate that even basic linear machine learning models can…

神经元与认知 · 定量生物学 2025-10-08 Valeriya Kirova , Dzerassa Kadieva , Daniil Vlasenko , Isak B. Blank , Fedor Ratnikov

Functional magnetic resonance imaging (fMRI) has provided invaluable insight into our understanding of human behavior. However, large inter-individual differences in both brain anatomy and functional localization after anatomical alignment…

应用统计 · 统计学 2021-11-03 Guoqing Wang , Abhirup Datta , Martin A. Lindquist

Functional brain connectivity, as revealed through distant correlations in the signals measured by functional Magnetic Resonance Imaging (fMRI), is a promising source of biomarkers of brain pathologies. However, establishing and using…

Functional connectomes capture brain interactions via synchronized fluctuations in the functional magnetic resonance imaging signal. If measured during rest, they map the intrinsic functional architecture of the brain. With task-driven…

神经元与认知 · 定量生物学 2013-04-16 Gaël Varoquaux , R. C. Craddock

Currently self-report pain ratings are the gold standard in clinical pain assessment. However, the development of objective automatic measures of pain could substantially aid pain diagnosis and therapy. Recent neuroimaging studies have…

图像与视频处理 · 电气工程与系统科学 2019-07-31 Daniel Lopez-Martinez , Ke Peng , Arielle Lee , David Borsook , Rosalind Picard

Functional magnetic resonance imaging (fMRI) enables non-invasive brain disorder classification by capturing blood-oxygen-level-dependent (BOLD) signals. However, most existing methods rely on functional connectivity (FC) via Pearson…

计算机视觉与模式识别 · 计算机科学 2026-02-10 Guoqi Yu , Xiaowei Hu , Angelica I. Aviles-Rivero , Anqi Qiu , Shujun Wang

The dynamic characteristics of functional network connectivity have been widely acknowledged and studied. Both shared and unique information has been shown to be present in the connectomes. However, very little has been known about whether…

神经元与认知 · 定量生物学 2020-06-18 Biao Cai , Gemeng Zhang , Aiying Zhang , Li Xiao , Wenxing Hu , Julia M. Stephen , Tony W. Wilson , Vince D. Calhoun , Yu-Ping Wang

Contemporary neuroscience has embraced network science to study the complex and self-organized structure of the human brain; one of the main outstanding issues is that of inferring from measure data, chiefly functional Magnetic Resonance…

最优化与控制 · 数学 2017-03-31 Giulia Prando , Mattia Zorzi , Alessandra Bertoldo , Alessandro Chiuso

In the past two decades, functional Magnetic Resonance Imaging has been used to relate neuronal network activity to cognitive processing and behaviour. Recently this approach has been augmented by algorithms that allow us to infer causal…

Acquisition of bimanual motor skills, critical in several applications ranging from robotic teleoperations to surgery, is associated with a protracted learning curve. Brain connectivity based on functional Near Infrared Spectroscopy (fNIRS)…

神经元与认知 · 定量生物学 2020-01-03 F. Deligianni , H. Singh , H. N. Modi , S. Jahani , M. Yucel , A. Darzi , D. R. Leff , G. Z. Yang

Many fMRI analyses examine functional connectivity, or statistical dependencies among remote brain regions. Yet popular methods for studying whole-brain functional connectivity often yield results that are difficult to interpret. Factor…

统计方法学 · 统计学 2024-09-24 Kyle Stanley , Nicole Lazar , Matthew Reimherr

Functional magnetic resonance (fMRI) is an invaluable tool in studying cognitive processes in vivo. Many recent studies use functional connectivity (FC), partial correlation connectivity (PC), or fMRI-derived brain networks to predict…

神经元与认知 · 定量生物学 2023-08-04 Anton Orlichenko , Gang Qu , Kuan-Jui Su , Anqi Liu , Hui Shen , Hong-Wen Deng , Yu-Ping Wang

This paper introduces a theoretical framework that connects neural network linear layers with the Mahalanobis distance, offering a new perspective on neural network interpretability. While previous studies have explored activation functions…

机器学习 · 计算机科学 2024-10-28 Alan Oursland

Functional Magnetic Resonance Imaging (fMRI) is a primary modality for studying brain activity. Modeling spatial dependence of imaging data at different scales is one of the main challenges of contemporary neuroimaging, and it could allow…

应用统计 · 统计学 2016-06-16 Stefano Castruccio , Hernando Ombao , Marc G. Genton
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