相关论文: Mechanically Regulated Cranial Growth in Infancy: …
Craniosynostosis is a medical condition that affects the growth of babies' heads, caused by an early fusion of cranial sutures. In recent decades, surgical treatments for craniosynostosis have significantly improved, leading to reduced…
Craniosynostosis, a condition affecting 1 in 2000 infants, is caused by premature fusing of cranial vault sutures, and manifests itself in abnormal skull growth patterns. Left untreated, the condition may lead to severe developmental…
The premature fusion of cranial bones, craniosynostosis, affects the correct development of the skull producing morphological malformations in newborns. To assess the susceptibility of each craniofacial articulation to close prematurely, we…
The surface morphology of the developing mammalian brain is crucial for understanding brain function and dysfunction. Computational modeling offers valuable insights into the underlying mechanisms for early brain folding. Recent findings…
Abnormal cortical folding patterns may be related to neurodevelopmental disorders such as lissencephaly and polymicrogyria. In this context, computational modeling is a powerful tool to provide a better understanding of the early brain…
Early brain development is characterized by the formation of a highly organized structural connectome. The interconnected nature of this connectome underlies the brain's cognitive abilities and influences its response to diseases and…
The assessment of craniofacial deformities requires patient data which is sparsely available. Statistical shape models provide realistic and synthetic data enabling comparisons of existing methods on a common dataset. We build the first…
Quantifying normative pediatric cranial development and suture ossification is crucial for diagnosing and treating growth-related cephalic disorders. Computed tomography (CT) is widely used to evaluate cranial and sutural deformities;…
We consider the mechanisms by which folds, or sulci (troughs) and gyri (crests), develop in the brain. This feature, common to many gyrencephalic species including humans, has attracted recent attention from soft matter physicists. It…
Understanding the growth and form of shapes is one of the most fundamental problems in biology. While many prior works have analyzed the beak shapes of Darwin's finches, other cranial features are relatively less explored. In this work, we…
We propose a multiscale mechanobiological model of bone remodelling to investigate the site-specific evolution of bone volume fraction across the midshaft of a femur. The model includes hormonal regulation and biochemical coupling of bone…
Cranial implant design is a challenging task, whose accuracy is crucial in the context of cranioplasty procedures. This task is usually performed manually by experts using computer-assisted design software. In this work, we propose and…
We adapt structural complexity analysis to three-dimensional signals, with an emphasis on brain magnetic resonance imaging (MRI). This framework captures the multiscale organization of volumetric data by coarse-graining the signal at…
Irregular bone remodeling is associated with a number of bone diseases such as osteoporosis and multiple myeloma. Computational and mathematical modeling can aid in therapy and treatment as well as understanding fundamental biology.…
Exploring the developing brain is a major issue in understanding what enables children to acquire amazing abilities, and how early disruptions can lead to a wide range of neurodevelopmental disorders. MRI plays a key role here by providing…
This paper presents an annotated dataset of brain MRI images designed to advance the field of brain symmetry study. Magnetic resonance imaging (MRI) has gained interest in analyzing brain symmetry in neonatal infants, and challenges remain…
This review highlights brain health as a dynamic process shaped by both genetic and environmental influences throughout development. Critical periods provide unique windows of heightened neural plasticity, during which genetic-environmental…
In this paper, we present a computer-assisted method for facial reconstruction. This method provides an estimation of the facial shape associated with unidentified skeletal remains. Current computer-assisted methods using a statistical…
In CMF surgery, the planning of bony movement to achieve a desired facial outcome is a challenging task. Current bone driven approaches focus on normalizing the bone with the expectation that the facial appearance will be corrected…
Morphological development into evolutionary patterns under structural instability is ubiquitous in living systems and often of vital importance for engineering structures. Here we propose a data-driven approach to understand and predict…