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Recent artificial intelligence (AI) systems have reached milestones in "grand challenges" ranging from Go to protein-folding. The capability to retrieve medical knowledge, reason over it, and answer medical questions comparably to…

In response to the pressing need for advanced clinical problem-solving tools in healthcare, we introduce BooksMed, a novel framework based on a Large Language Model (LLM). BooksMed uniquely emulates human cognitive processes to deliver…

Medical Question-Answering (QA) encompasses a broad spectrum of tasks, including multiple choice questions (MCQ), open-ended text generation, and complex computational reasoning. Despite this variety, a unified framework for delivering…

计算与语言 · 计算机科学 2025-06-23 Xiaotian Zhang , Yuan Wang , Zhaopeng Feng , Ruizhe Chen , Zhijie Zhou , Yan Zhang , Hongxia Xu , Jian Wu , Zuozhu Liu

Recent developments in Large Language Model (LLM)-based agents have shown impressive capabilities spanning multiple domains, exemplified by deep research systems that demonstrate superior performance on complex information-seeking and…

Large language models (LLMs) show promise for healthcare question answering, but clinical use is limited by weak verification, insufficient evidence grounding, and unreliable confidence signalling. We propose a multi-agent medical QA…

计算与语言 · 计算机科学 2026-02-17 Naeimeh Nourmohammadi , Md Meem Hossain , The Anh Han , Safina Showkat Ara , Zia Ush Shamszaman

Background: Biomedical entity normalization is critical to biomedical research because the richness of free-text clinical data, such as progress notes, can often be fully leveraged only after translating words and phrases into structured…

计算与语言 · 计算机科学 2024-05-27 Nicholas J Dobbins

Understanding complex biomolecular mechanisms requires multi-step reasoning across molecular interactions, signaling cascades, and metabolic pathways. While large language models(LLMs) show promise in such tasks, their application to…

人工智能 · 计算机科学 2025-11-12 Tianwen Lyu , Xiang Zhuang , Keyan Ding , Xinzhe Cao , Lei Liang , Wei Zhao , Qiang Zhang , Huajun Chen

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

计算与语言 · 计算机科学 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

Large language models (LLMs) have become important tools in solving biological problems, offering improvements in accuracy and adaptability over conventional methods. Several benchmarks have been proposed to evaluate the performance of…

Background: Recent advancements in large language models (LLMs) offer potential benefits in healthcare, particularly in processing extensive patient records. However, existing benchmarks do not fully assess LLMs' capability in handling…

With the increasing application of large language models (LLMs) in the medical domain, evaluating these models' performance using benchmark datasets has become crucial. This paper presents a comprehensive survey of various benchmark…

Recently, Large Language Models (LLMs) have showcased remarkable capabilities in natural language understanding. While demonstrating proficiency in everyday conversations and question-answering situations, these models frequently struggle…

计算与语言 · 计算机科学 2023-08-28 Chaoyi Wu , Weixiong Lin , Xiaoman Zhang , Ya Zhang , Yanfeng Wang , Weidi Xie

Incentivizing the reasoning ability of Multimodal Large Language Models (MLLMs) is essential for medical applications to transparently analyze medical scans and provide reliable diagnosis. However, existing medical MLLMs rely solely on…

计算机视觉与模式识别 · 计算机科学 2025-10-22 Lehan Wang , Yi Qin , Honglong Yang , Xiaomeng Li

The applications of large language models (LLMs) are promising for biomedical and healthcare research. Despite the availability of open-source LLMs trained using a wide range of biomedical data, current research on the applications of LLMs…

机器学习 · 计算机科学 2024-09-25 Tianyu Liu , Yijia Xiao , Xiao Luo , Hua Xu , W. Jim Zheng , Hongyu Zhao

The emergence of advanced reasoning capabilities in Large Language Models (LLMs) marks a transformative development in healthcare applications. Beyond merely expanding functional capabilities, these reasoning mechanisms enhance decision…

人工智能 · 计算机科学 2025-08-27 Armin Berger , Sarthak Khanna , David Berghaus , Rafet Sifa

Background: Identification of the interactions and regulatory relations between biomolecules play pivotal roles in understanding complex biological systems and the mechanisms underlying diverse biological functions. However, the collection…

计算与语言 · 计算机科学 2025-04-24 Gilchan Park , Byung-Jun Yoon , Xihaier Luo , Vanessa López-Marrero , Shinjae Yoo , Shantenu Jha

Large Language Models (LLMs) have demonstrated significant potential in medical Question Answering (QA), yet they remain prone to hallucinations and ungrounded reasoning, limiting their reliability in high-stakes clinical scenarios. While…

信息检索 · 计算机科学 2026-01-09 Jessica Ryan , Alexander I. Gumilang , Robert Wiliam , Derwin Suhartono

Recent advances in the healthcare industry have led to an abundance of unstructured data, making it challenging to perform tasks such as efficient and accurate information retrieval at scale. Our work offers an all-in-one scalable solution…

信息检索 · 计算机科学 2023-02-15 Shreya Saxena , Raj Sangani , Siva Prasad , Shubham Kumar , Mihir Athale , Rohan Awhad , Vishal Vaddina

Coreference resolution in biomedical texts presents unique challenges due to complex domain-specific terminology, high ambiguity in mention forms, and long-distance dependencies between coreferring expressions. In this work, we present a…

计算与语言 · 计算机科学 2025-10-30 Nourah M Salem , Elizabeth White , Michael Bada , Lawrence Hunter

Large language models (LLMs) have excelled across domains, also delivering notable performance on the medical evaluation benchmarks, such as MedQA. However, there still exists a significant gap between the reported performance and the…

计算与语言 · 计算机科学 2024-06-06 Yuxuan Zhou , Xien Liu , Chen Ning , Ji Wu