相关论文: Flow Autoencoders are Effective Protein Tokenizers

Deep learning based image compression has recently witnessed exciting progress and in some cases even managed to surpass transform coding based approaches that have been established and refined over many decades. However, state-of-the-art…

Protein structure prediction models are now capable of generating accurate 3D structural hypotheses from sequence alone. However, they routinely fail to capture the conformational diversity of dynamic biomolecular complexes, often requiring…

Diffusion models create data from noise by inverting the forward paths of data towards noise and have emerged as a powerful generative modeling technique for high-dimensional, perceptual data such as images and videos. Rectified flow is a…

Diffusion models have recently dominated image synthesis tasks. However, the iterative denoising process is expensive in computations at inference time, making diffusion models less practical for low-latency and scalable real-world…

Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein function or structure. Existing approaches usually pretrain protein language models on a large number of unlabeled amino acid…

Artificial intelligence is continuously seeking novel challenges and benchmarks to effectively measure performance and to advance the state-of-the-art. In this paper we introduce KANDY, a benchmarking framework that can be used to generate…

Denoising diffusion models produce high-fidelity image samples by capturing the image distribution in a progressive manner while initializing with a simple distribution and compounding the distribution complexity. Although these models have…

Most existing methods in vision-language retrieval match two modalities by either comparing their global feature vectors which misses sufficient information and lacks interpretability, detecting objects in images or videos and aligning the…

Recently, many generative models for de novo protein structure design have emerged. Yet, only few tackle the difficult task of directly generating fully atomistic structures jointly with the underlying amino acid sequence. This is…

Flow-based models have proven successful for time-series generation, particularly when defined in lower-dimensional latent spaces that enable efficient sampling. However, how to design latent representations with desirable equivariance…

Text-to-image generation is a significant domain in modern computer vision and has achieved substantial improvements through the evolution of generative architectures. Among these, there are diffusion-based models that have demonstrated…

Understanding the dynamic nature of protein structures is essential for comprehending their biological functions. While significant progress has been made in predicting static folded structures, modeling protein motions on microsecond to…

Attention mechanism has been crucial for image diffusion models, however, their quadratic computational complexity limits the sizes of images we can process within reasonable time and memory constraints. This paper investigates the…

In recent years, using a deep convolutional neural network (CNN) as a feature encoder (or backbone) is the most commonly observed architectural pattern in several computer vision methods, and semantic segmentation is no exception. The two…

Diffusion language models generate text through iterative refinement, a process that is often computationally inefficient because many tokens reach stability long before the final denoising step. We introduce a training-free, token-level…

Efficient encoding and representation of large 3D molecular structures with high fidelity is critical for biomolecular design applications. Despite this, many representation learning approaches restrict themselves to modeling smaller…

An autoencoder is a self-supervised machine-learning network trained to output a quantity identical to the input. Owing to its structure possessing a bottleneck with a lower dimension, an autoencoder works to achieve data compression,…

Modern language models are trained almost exclusively on token sequences produced by a fixed tokenizer, an external lossless compressor often over UTF-8 byte sequences, thereby coupling the model to that compressor. This work introduces…

This study introduces a novel knowledge enhanced tokenisation mechanism, K-Tokeniser, for clinical text processing. Technically, at initialisation stage, K-Tokeniser populates global representations of tokens based on semantic types of…

Current multi-modal image fusion methods typically rely on task-specific models, leading to high training costs and limited scalability. While generative methods provide a unified modeling perspective, they often suffer from slow inference…