相关论文: Flow Autoencoders are Effective Protein Tokenizers

Diffusion models can learn rich representations during data generation, showing potential for Self-Supervised Learning (SSL), but they face a trade-off between generative quality and discriminative performance. Their iterative sampling also…

Autoregressive (AR) modeling has achieved remarkable success in natural language processing by enabling models to generate text with coherence and contextual understanding through next token prediction. Recently, in image generation, VAR…

The growing significance of RNA engineering in diverse biological applications has spurred interest in developing AI methods for structure-based RNA design. While diffusion models have excelled in protein design, adapting them for RNA…

A significant amount of protein function requires binding small molecules, including enzymatic catalysis. As such, designing binding pockets for small molecules has several impactful applications ranging from drug synthesis to energy…

Latent variable generative models have emerged as powerful tools for generative tasks including image and video synthesis. These models are enabled by pretrained autoencoders that map high resolution data into a compressed lower dimensional…

Diffusion autoencoders (DAs) are variants of diffusion generative models that use an input-dependent latent variable to capture representations alongside the diffusion process. These representations, to varying extents, can be used for…

Token representation strategies within large-scale neural architectures often rely on contextually refined embeddings, yet conventional approaches seldom encode structured relationships explicitly within token interactions. Self-attention…

Recent advances in multimodal models highlight the pivotal role of image tokenization in high-resolution image generation. By compressing images into compact latent representations, tokenizers enable generative models to operate in…

We investigate methods to reduce inference time and memory footprint in stable diffusion models by introducing lightweight decoders for both image and video synthesis. Traditional latent diffusion pipelines rely on large Variational…

Inverse protein folding is challenging due to its inherent one-to-many mapping characteristic, where numerous possible amino acid sequences can fold into a single, identical protein backbone. This task involves not only identifying viable…

Diffusion generative models have emerged as a powerful framework for addressing problems in structural biology and structure-based drug design. These models operate directly on 3D molecular structures. Due to the unfavorable scaling of…

Speech tokenizers serve as foundational components for speech language models, yet current designs exhibit several limitations, including: 1) dependence on multi-layer residual vector quantization structures or high frame rates, 2) reliance…

Physics-integrated generative modeling is a class of hybrid or grey-box modeling in which we augment the the data-driven model with the physics knowledge governing the data distribution. The use of physics knowledge allows the generative…

Image tokenization plays a central role in modern generative modeling by mapping visual inputs into compact representations that serve as an intermediate signal between pixels and generative models. Diffusion-based decoders have recently…

We propose task-adaptive tokenization as a way to adapt the generation pipeline to the specifics of a downstream task and enhance long-form generation in mental health. Inspired by insights from cognitive science, our task-adaptive…

Representation learning and \emph{de novo} generation of proteins are pivotal computational biology tasks. Whilst natural language processing (NLP) techniques have proven highly effective for protein sequence modelling, structure modelling…

Recent advances in large language models (LLMs) have enabled breakthroughs in many multimodal generation tasks, but a significant performance gap still exists in text-to-motion generation, where LLM-based methods lag far behind non-LLM…

Data representation remains a fundamental challenge in machine learning, particularly when adapting sequence-based architectures like Transformers and Large Language Models (LLMs) for structured tabular data. Existing methods often fail to…

The Boltzmann distribution of a protein provides a roadmap to all of its functional states. Normalizing flows are a promising tool for modeling this distribution, but current methods are intractable for typical pharmacological targets; they…

This paper develops an end-to-end fuzzy encoder-decoder architecture for enhancing vision-based multi-modal deep spiking Q-networks in autonomous driving. The method addresses two core limitations of spiking reinforcement learning:…