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United States healthcare systems are struggling to meet the growing demand for neurological care, particularly in Alzheimer's disease and related dementias (ADRD). Generative AI built on language models (LLMs) now enables agentic AI systems…

The discovery of novel small molecule drugs remains a critical scientific challenge with far-reaching implications for treating diseases and advancing human health. Traditional drug development--especially for small molecule…

生物大分子 · 定量生物学 2025-04-01 Bowen Gao , Yanwen Huang , Yiqiao Liu , Wenxuan Xie , Wei-Ying Ma , Ya-Qin Zhang , Yanyan Lan

Developing artificial intelligence (AI) for clinical research requires a comprehensive data foundation that supports model training and rigorous evaluation. Here, we introduce TrialPanorama, a large-scale structured resource that aggregates…

人工智能 · 计算机科学 2025-12-17 Zifeng Wang , Jiacheng Lin , Qiao Jin , Junyi Gao , Jathurshan Pradeepkumar , Pengcheng Jiang , Zhiyong Lu , Jimeng Sun

Generative Artificial Intelligence (GenAI) is taking the world by storm. It promises transformative opportunities for advancing and disrupting existing practices, including healthcare. From large language models (LLMs) for clinical note…

The advancement of large language model (LLM) based agents has shifted AI evaluation from single-turn response assessment to multi-step task completion in interactive environments. We present an empirical study evaluating frontier AI models…

人工智能 · 计算机科学 2026-01-15 Logan Ritchie , Sushant Mehta , Nick Heiner , Mason Yu , Edwin Chen

Agents based on Large Language Models (LLMs) have shown promise for performing sophisticated software engineering tasks autonomously. In addition, there has been progress towards developing agents that can perform parts of the research…

计算与语言 · 计算机科学 2026-04-23 Nicholas Edwards , Yukyung Lee , Yujun Audrey Mao , Yulu Qin , Sebastian Schuster , Najoung Kim

The recent advance in Large Language Models (LLMs) has shaped a new paradigm of AI agents, i.e., LLM-based agents. Compared to standalone LLMs, LLM-based agents substantially extend the versatility and expertise of LLMs by enhancing LLMs…

软件工程 · 计算机科学 2025-12-04 Junwei Liu , Kaixin Wang , Yixuan Chen , Xin Peng , Zhenpeng Chen , Lingming Zhang , Yiling Lou

This study applies Large Language Models (LLMs) to two foundational Electronic Health Record (EHR) data science tasks: structured data querying (using programmatic languages, Python/Pandas) and information extraction from unstructured…

计算与语言 · 计算机科学 2026-01-29 Juan Jose Rubio Jan , Jack Wu , Julia Ive

The efficacy of AI agents in healthcare research is hindered by their reliance on static, predefined strategies. This creates a critical limitation: agents can become better tool-users but cannot learn to become better strategic planners, a…

人工智能 · 计算机科学 2025-08-08 Huiya Zhao , Yinghao Zhu , Zixiang Wang , Yasha Wang , Junyi Gao , Liantao Ma

Large Language Model (LLM) based agents are powerful yet fundamentally static after deployment, lacking the ability to autonomously expand capabilities, generate new tools, or evolve their reasoning. This work introduces a hierarchical…

计算与语言 · 计算机科学 2026-01-21 Indrajit Kar , Sammy Zonunpuia , Zonunfeli Ralte

The rise of large language models (LLMs) has transformed healthcare by offering clinical guidance, yet their direct deployment to patients poses safety risks due to limited domain expertise. To mitigate this, we propose repositioning LLMs…

计算与语言 · 计算机科学 2025-10-14 Wenya Xie , Qingying Xiao , Yu Zheng , Xidong Wang , Junying Chen , Ke Ji , Anningzhe Gao , Prayag Tiwari , Xiang Wan , Feng Jiang , Benyou Wang

Clinical decision-making increasingly relies on timely and context-aware access to patient information within Electronic Health Records (EHRs), yet most existing natural language question-answering (QA) systems are evaluated solely on…

Autonomous coding agents built on large language models (LLMs) can now solve many general software and machine learning tasks, but they remain ineffective on complex, domain-specific scientific problems. Medical imaging is a particularly…

计算机视觉与模式识别 · 计算机科学 2025-12-22 Roshan Kenia , Xiaoman Zhang , Pranav Rajpurkar

Large language models (LLMs) hold promise for transforming healthcare, from streamlining administrative and clinical workflows to enriching patient engagement and advancing clinical decision-making. However, their successful integration…

计算机与社会 · 计算机科学 2025-04-04 Mohammed Al-Garadi , Tushar Mungle , Abdulaziz Ahmed , Abeed Sarker , Zhuqi Miao , Michael E. Matheny

Natural language generation (NLG) is the key technology to achieve generative artificial intelligence (AI). With the breakthroughs in large language models (LLMs), NLG has been widely used in various medical applications, demonstrating the…

计算与语言 · 计算机科学 2025-05-08 Mengxian Lyu , Xiaohan Li , Ziyi Chen , Jinqian Pan , Cheng Peng , Sankalp Talankar , Yonghui Wu

Large Language Models (LLMs) show promise in biomedicine but lack true causal understanding, relying instead on correlations. This paper envisions causal LLM agents that integrate multimodal data (text, images, genomics, etc.) and perform…

人工智能 · 计算机科学 2025-05-23 Adib Bazgir , Amir Habibdoust Lafmajani , Yuwen Zhang

In recent years, data science agents powered by Large Language Models (LLMs), known as "data agents," have shown significant potential to transform the traditional data analysis paradigm. This survey provides an overview of the evolution,…

人工智能 · 计算机科学 2025-12-01 Maojun Sun , Ruijian Han , Binyan Jiang , Houduo Qi , Defeng Sun , Yancheng Yuan , Jian Huang

The advancement in generative AI could be boosted with more accessible mathematics. Beyond human-AI chat, large language models (LLMs) are emerging in programming, algorithm discovery, and theorem proving, yet their genomics application is…

其他定量生物学 · 定量生物学 2023-07-07 Melanie Swan , Takashi Kido , Eric Roland , Renato P. dos Santos

Workforce transformations are difficult to forecast and costly to mismanage. In particular, the integration of artificial intelligence into knowledge work currently affects a substantial share of the global workforce, yet this transition…

人机交互 · 计算机科学 2026-05-20 Sumer S. Vaid , Ashley V. Whillans

Large language model-based agents are increasingly being integrated into core battlefield functions, including intelligence analysis, data fusion, and battlefield management. This paper argues that the very features that make such agents…

计算机与社会 · 计算机科学 2026-04-09 Jovana Davidovic