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Alzheimer's disease is a major cause of dementia. Its diagnosis requires accurate biomarkers that are sensitive to disease stages. In this respect, we regard probabilistic classification as a method of designing a probabilistic biomarker…

机器学习 · 计算机科学 2017-06-06 Murat Seckin Ayhan , Vijay Raghavan , Alzheimer's disease Neuroimaging Initiative

Due to the rapid development of high-throughput experimental techniques and fast-dropping prices, many transcriptomic datasets have been generated and accumulated in the public domain. Meta-analysis combining multiple transcriptomic studies…

应用统计 · 统计学 2019-05-17 Zhiguang Huo , Chi Song , George Tseng

Predicting whether a molecule can cross the blood-brain barrier (BBB) is a key step in early-stage neuro-pharmaceutical design, directly influencing the efficiency and success rate of drug development. Traditional methods based on…

定量方法 · 定量生物学 2026-03-16 Zihan Yang , Yuchen Xiao

The interface between stochastic analysis and machine learning is a rapidly evolving field, with path signatures - iterated integrals that provide faithful, hierarchical representations of paths - offering a principled and universal feature…

机器学习 · 统计学 2025-06-26 Csaba Tóth

Biomarker discovery is vital in advancing personalized medicine, offering insights into disease diagnosis, prognosis, and therapeutic efficacy. Traditionally, the identification and validation of biomarkers heavily depend on extensive…

机器学习 · 计算机科学 2024-09-25 Wangyang Ying , Dongjie Wang , Xuanming Hu , Ji Qiu , Jin Park , Yanjie Fu

This study presents a systematic machine-learning approach for classifying acute pain from raw electrophysiological signals. We address binary and ternary classification tasks, leveraging Power-In-Band (PIB) and signal coherence as…

信号处理 · 电气工程与系统科学 2025-03-06 Sidharth Sidharth , Vishwas Sathish , Shweta Bansal , Samantha Sun , Timmy Pham , Kurt Weaver , Rajesh P. N. Rao , Jeffrey Herron

Machine learning-based imaging diagnostics has recently reached or even superseded the level of clinical experts in several clinical domains. However, classification decisions of a trained machine learning system are typically…

Discovering imaging biomarkers for autism spectrum disorder (ASD) is critical to help explain ASD and predict or monitor treatment outcomes. Toward this end, deep learning classifiers have recently been used for identifying ASD from…

计算机视觉与模式识别 · 计算机科学 2019-03-15 Xiaoxiao Li , Nicha C. Dvornek , Yuan Zhou , Juntang Zhuang , Pamela Ventola , James S. Duncan

Prostate cancer (PCa) is a severe disease among men globally. It is important to identify PCa early and make a precise diagnosis for effective treatment. For PCa diagnosis, Multi-parametric magnetic resonance imaging (mpMRI) emerged as an…

图像与视频处理 · 电气工程与系统科学 2023-10-11 Anil B. Gavade , Neel Kanwal , Priyanka A. Gavade , Rajendra Nerli

A new paradigm is beginning to emerge in Radiology with the advent of increased computational capabilities and algorithms. This has led to the ability of real time learning by computer systems of different lesion types to help the…

Although machine learning (ML) models of AI achieve high performances in medicine, they are not free of errors. Empowering clinicians to identify incorrect model recommendations is crucial for engendering trust in medical AI. Explainable AI…

人工智能 · 计算机科学 2022-12-20 Isil Guzey , Ozlem Ucar , Nukhet Aladag Ciftdemir , Betul Acunas

We investigate the molecular gene expressions studies and public databases for disease modelling using Probabilistic Graphical Models and Bayesian Inference. A case study on Spinal Muscle Atrophy Genome-Wide Association Study results is…

应用统计 · 统计学 2023-11-30 Mohammed Ezzat Helal , Manal Ezzat Helal , Sherif Fadel Fahmy

Motivation: Tumor classification using Imaging Mass Spectrometry (IMS) data has a high potential for future applications in pathology. Due to the complexity and size of the data, automated feature extraction and classification steps are…

In recent years there has been increased use of machine learning (ML) techniques within mathematics, including symbolic computation where it may be applied safely to optimise or select algorithms. This paper explores whether using…

符号计算 · 计算机科学 2024-01-31 Lynn Pickering , Tereso Del Rio Almajano , Matthew England , Kelly Cohen

Traditional drug discovery is a long, expensive, and complex process. Advances in Artificial Intelligence (AI) and Machine Learning (ML) are beginning to change this narrative. Here, we provide a comprehensive overview of different AI and…

There are a few challenges related to the task of biomedical named entity recognition, which are: the existing methods consider a fewer number of biomedical entities (e.g., disease, symptom, proteins, genes); and these methods do not…

计算与语言 · 计算机科学 2022-07-05 Shaina Raza , Brian Schwartz

Melanoma is one of the most aggressive and deadliest skin cancers, leading to mortality if not detected and treated in the early stages. Artificial intelligence techniques have recently been developed to help dermatologists in the early…

机器学习 · 计算机科学 2026-02-19 Wadduwage Shanika Perera , ABM Islam , Van Vung Pham , Min Kyung An

A great deal of effort has been devoted to discovering a particular genetic disorder, but its classification across a broad spectrum of disorder classes and types remains elusive. Early diagnosis of genetic disorders enables timely…

人工智能 · 计算机科学 2024-12-04 Abu Bakar Siddik , Faisal R. Badal , Afroza Islam

Predictive modeling in healthcare continues to be an active actuarial research topic as more insurance companies aim to maximize the potential of Machine Learning approaches to increase their productivity and efficiency. In this paper, the…

机器学习 · 计算机科学 2023-11-27 Ugochukwu Orji , Elochukwu Ukwandu

Integrating heterogeneous biomedical data including imaging, omics, and clinical records supports accurate diagnosis and personalised care. Graph-based models fuse such non-Euclidean data by capturing spatial and relational structure, yet…

基因组学 · 定量生物学 2025-05-06 Alireza Sadeghi , Farshid Hajati , Ahmadreza Argha , Nigel H Lovell , Min Yang , Hamid Alinejad-Rokny