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Crohn's Disease (CD) and Ulcerative Colitis (UC) are the two main Inflammatory Bowel Disease (IBD) types. We developed deep learning models to identify histological disease features for both CD and UC using only endoscopic labels. We…

Inflammatory Bowel Disease (IBD), including Crohn's Disease (CD) and Ulcerative Colitis (UC), presents significant public health challenges due to its complex etiology. Motivated by the IBD study of the Integrative Human Microbiome Project,…

Inflammatory bowel disease (IBD) involves chronic inflammation of the digestive tract, with treatment options often burdened by adverse effects. Identifying biomarkers for personalized treatment is crucial. While immune cells play a key…

Crohn's disease (CD) is a chronic and relapsing inflammatory condition that affects segments of the gastrointestinal tract. CD activity is determined by histological findings, particularly the density of neutrophils observed on Hematoxylin…

Ulcerative colitis (UC) is one of the most common forms of inflammatory bowel disease (IBD) characterized by inflammation of the mucosal layer of the colon. Diagnosis of UC is based on clinical symptoms, and then confirmed based on…

The tremendous boost in the next generation sequencing and in the omics technologies makes it possible to characterize human gut microbiome (the collective genomes of the microbial community that reside in our gastrointestinal tract). While…

Inflammatory bowel diseases (IBD) are complex diseases in which the gut microbiota is attacked by the immune system of genetically predisposed subjects when they are exposed to yet unclear environmental factors. The complexity of this class…

International Classification of Diseases (ICD) is a globally recognized coding system that records diagnostic events during each patient encounter, providing a standardized data foundation for various clinical tasks. However, the irregular…

Cells in multicellular organisms coordinate to form structural and functional niches. With spatial transcriptomics (ST) enabling gene expression profiling in spatial contexts, it has been revealed that spatial niches serve as cohesive and…

Accurately predicting and detecting interstitial lung disease (ILD) patterns given any computed tomography (CT) slice without any pre-processing prerequisites, such as manually delineated regions of interest (ROIs), is a clinically…

Differentiating between Intestinal Tuberculosis (ITB) and Crohn's Disease (CD) poses a significant clinical challenge due to their similar symptoms, clinical presentations, and imaging features. This study leverages Computed Tomography…

Donor-level disease classification from single-cell RNA sequencing (scRNA-seq) requires strict donor-aware cross-validation: naive pipelines that split cells randomly conflate training and test donors, inflating reported performance through…

As the therapeutic target for Inflammatory Bowel Disease (IBD) shifts toward histologic remission, the accurate assessment of microscopic inflammation has become increasingly central for evaluating disease activity and response to…

The automated Interstitial Lung Diseases (ILDs) classification technique is essential for assisting clinicians during the diagnosis process. Detecting and classifying ILDs patterns is a challenging problem. This paper introduces an…

Inflammatory bowel disease (IBD), in particular ulcerative colitis (UC), is graded by endoscopists and this assessment is the basis for risk stratification and therapy monitoring. Presently, endoscopic characterisation is largely operator…

Grading inflammatory bowel disease (IBD) activity using standardized histopathological scoring systems remains challenging due to resource constraints and inter-observer variability. In this study, we developed a deep learning model to…

Interstitial lung diseases are a large group of heterogeneous diseases characterized by different degrees of alveolitis and pulmonary fibrosis. Accurately diagnosing these diseases has significant guiding value for formulating treatment…

Breast cancer is the most diagnosed cancer and the most predominant cause of death in women worldwide. Imaging techniques such as the breast cancer pathology helps in the diagnosis and monitoring of the disease. However identification of…

Crohn's disease, one of two inflammatory bowel diseases (IBD), affects 200,000 people in the UK alone, or roughly one in every 500. We explore the feasibility of deep learning algorithms for identification of terminal ileal Crohn's disease…

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification…