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This paper presents our solution for the MIDOG 2025 Challenge Track 2, which focuses on binary classification of normal mitotic figures (NMFs) versus atypical mitotic figures (AMFs) in histopathological images. Our approach leverages a…

计算机视觉与模式识别 · 计算机科学 2025-08-27 Yosuke Yamagishi , Shouhei Hanaoka

Atypical mitotic figures (AMFs) are rare abnormal cell divisions associated with tumor aggressiveness and poor prognosis. Their detection remains a significant challenge due to subtle morphological cues, class imbalance, and inter-observer…

计算机视觉与模式识别 · 计算机科学 2026-01-13 Lavish Ramchandani , Gunjan Deotale , Dev Kumar Das

Atypical mitotic figures (AMFs) are important histopathological markers yet remain challenging to identify consistently, particularly under domain shift stemming from scanner, stain, and acquisition differences. We present a simple…

计算机视觉与模式识别 · 计算机科学 2025-08-29 Kaustubh Atey , Sameer Anand Jha , Gouranga Bala , Amit Sethi

Atypical mitotic figures (AMFs) represent abnormal cell division associated with poor prognosis. Yet their detection remains difficult due to low prevalence, subtle morphology, and inter-observer variability. The MIDOG 2025 challenge…

图像与视频处理 · 电气工程与系统科学 2025-10-15 Guillaume Balezo , Hana Feki , Raphaël Bourgade , Lily Monnier , Matthieu Blons , Alice Blondel , Etienne Decencière , Albert Pla Planas , Thomas Walter

Mitotic figures are classified into typical and atypical variants, with atypical counts correlating strongly with tumor aggressiveness. Accurate differentiation is therefore essential for patient prognostication and resource allocation, yet…

图像与视频处理 · 电气工程与系统科学 2025-09-19 Mieko Ochi , Bae Yuan

Atypical mitotic figures (AMFs) are clinically relevant indicators of abnormal cell division, yet their reliable detection remains challenging due to morphological ambiguity and scanner variability. In this work, we investigated three…

图像与视频处理 · 电气工程与系统科学 2025-09-08 Biwen Meng , Xi Long , Jingxin Liu

Recognizing atypical mitotic figures in histopathology images allows physicians to correctly assess tumor aggressiveness. Although machine learning models could be exploited for automatically performing such a task, under domain shift these…

图像与视频处理 · 电气工程与系统科学 2025-09-10 Gennaro Percannella , Mattia Sarno , Francesco Tortorella , Mario Vento

Deep learning has driven significant advances in mitotic figure analysis within computational pathology. In this paper, we present our approach to the Mitosis Domain Generalization (MIDOG) 2025 Challenge, which consists of two distinct…

图像与视频处理 · 电气工程与系统科学 2025-09-04 Shuting Xu , Runtong Liu , Zhixuan Chen , Junlin Hou , Hao Chen

Accurate mitotic figure classification is crucial in computational pathology, as mitotic activity informs cancer grading and patient prognosis. Distinguishing atypical mitotic figures (AMFs), which indicate higher tumor aggressiveness, from…

图像与视频处理 · 电气工程与系统科学 2025-09-04 Hana Feki , Alice Blondel , Thomas Walter

This report details our submission to the Mitotic Domain Generalization (MIDOG) 2025 challenge, which addresses the critical task of mitotic figure detection in histopathology for cancer prognostication. Following the "Bitter…

图像与视频处理 · 电气工程与系统科学 2025-09-04 Zhuoyan Shen , Esther Bär , Maria Hawkins , Konstantin Bräutigam , Charles-Antoine Collins-Fekete

Atypical mitosis marks a deviation in the cell division process that has been shown be an independent prognostic marker for tumor malignancy. However, atypical mitosis classification remains challenging due to low prevalence, at times…

Mitotic figure detection in histopathology images remains challenging due to significant domain shifts across different scanners, staining protocols, and tissue types. This paper presents our approach for the MIDOG 2025 challenge Track 1,…

The performance of deep learning models is known to scale with data quantity and diversity. In pathology, as in many other medical imaging domains, the availability of labeled images for a specific task is often limited. Self-supervised…

计算机视觉与模式识别 · 计算机科学 2026-02-05 Jonas Ammeling , Jonathan Ganz , Emely Rosbach , Ludwig Lausser , Christof A. Bertram , Katharina Breininger , Marc Aubreville

Motivation: Accurate classification of mitotic figures into normal and atypical types is crucial for tumor prognostication in digital pathology. However, developing robust deep learning models for this task is challenging due to the subtle…

Foundation models (FMs), i.e., models trained on a vast amount of typically unlabeled data, have become popular and available recently for the domain of histopathology. The key idea is to extract semantically rich vectors from any input…

计算机视觉与模式识别 · 计算机科学 2024-12-17 Jonathan Ganz , Jonas Ammeling , Emely Rosbach , Ludwig Lausser , Christof A. Bertram , Katharina Breininger , Marc Aubreville

Making histopathology image classifiers robust to a wide range of real-world variability is a challenging task. Here, we describe a candidate deep learning solution for the Mitosis Domain Generalization Challenge 2022 (MIDOG) to address the…

图像与视频处理 · 电气工程与系统科学 2023-01-04 Maxime W. Lafarge , Viktor H. Koelzer

Mitotic figure (MF) detection in histopathology images is challenging due to large variations in slide scanners, staining protocols, tissue types, and the presence of artifacts. This paper presents a collection of training techniques - a…

计算机视觉与模式识别 · 计算机科学 2025-08-28 Christian Marzahl , Brian Napora

Mitotic figure detection remains a challenging task in computational pathology due to domain variability and morphological complexity. This paper describes our participation in the MIDOG 2025 challenge, focusing on robust mitotic figure…

图像与视频处理 · 电气工程与系统科学 2025-09-04 Euiseop Song , Jaeyoung Park , Jaewoo Park

Atypical mitotic figures are important biomarkers of tumor aggressiveness in histopathology, yet reliable recognition remains challenging due to severe class imbalance and variability across imaging domains. We present a DenseNet-121-based…

计算机视觉与模式识别 · 计算机科学 2025-11-04 Adinath Dukre , Ankan Deria , Yutong Xie , Imran Razzak

Mitotic figures (MFs) are relevant biomarkers in tumor grading. Differentiating atypical MFs (AMFs) from normal MFs (NMFs) remains difficult, as manual annotation is time-consuming and subjective. In this work an ensemble of ConvNeXtBase…

计算机视觉与模式识别 · 计算机科学 2025-08-29 Sara Krauss , Ellena Spieß , Daniel Hieber , Frank Kramer , Johannes Schobel , Dominik Müller
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