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Imagine a world where clinical trials need far fewer patients to achieve the same statistical power, thanks to the knowledge encoded in large language models (LLMs). We present a novel framework for hierarchical Bayesian modeling of adverse…

统计方法学 · 统计学 2025-11-21 Shota Arai , David Selby , Andrew Vargo , Sebastian Vollmer

The driving factors behind the development of large language models (LLMs) with impressive learning capabilities are their colossal model sizes and extensive training datasets. Along with the progress in natural language processing, LLMs…

Despite the growing scale of medical Vision-Language datasets, the impact of dataset quality on model performance remains under-explored. We introduce Open-PMC, a high-quality medical dataset from PubMed Central, containing 2.2 million…

While frontier large language models demonstrate strong reasoning and mathematical capabilities, the practical process of training domain-specialized scientific language models from raw sources remains under-documented. In this work, we…

人工智能 · 计算机科学 2026-02-20 Anuj Gupta

Language models pre-trained on scientific literature corpora have substantially advanced scientific discovery by offering high-quality feature representations for downstream applications. However, these features are often not interpretable,…

计算与语言 · 计算机科学 2023-02-17 Cai Yang , Addie Woicik , Hoifung Poon , Sheng Wang

Several studies showed that Large Language Models (LLMs) can answer medical questions correctly, even outperforming the average human score in some medical exams. However, to our knowledge, no study has been conducted to assess the ability…

计算与语言 · 计算机科学 2025-01-03 Asma Ben Abacha , Wen-wai Yim , Yujuan Fu , Zhaoyi Sun , Meliha Yetisgen , Fei Xia , Thomas Lin

Language-molecule models have emerged as an exciting direction for molecular discovery and understanding. However, training these models is challenging due to the scarcity of molecule-language pair datasets. At this point, datasets have…

计算与语言 · 计算机科学 2024-07-08 Carl Edwards , Qingyun Wang , Lawrence Zhao , Heng Ji

Tabular medical records remain the most readily available data format for applying machine learning in healthcare. However, traditional data preprocessing ignores valuable contextual information in tables and requires substantial manual…

Medicine is rife with high-stakes uncertainty. Doctors routinely make clinical judgments and decisions that juggle many fundamental unknowns, like predictions about what might be causing a patients' symptoms or decisions about what…

Drug discovery is a critical task in biomedical natural language processing (NLP), yet explainable drug discovery remains underexplored. Meanwhile, large language models (LLMs) have shown remarkable abilities in natural language…

计算与语言 · 计算机科学 2025-02-28 Kai Zhang , Rui Zhu , Shutian Ma , Jingwei Xiong , Yejin Kim , Fabricio Murai , Xiaozhong Liu

Particularly in low-data regimes, an outstanding challenge in machine learning is developing principled techniques for augmenting our models with suitable priors. This is to encourage them to learn in ways that are compatible with our…

机器学习 · 计算机科学 2022-10-25 Kristy Choi , Chris Cundy , Sanjari Srivastava , Stefano Ermon

This paper introduces M$^{3}$-20M, a large-scale Multi-Modal Molecule dataset that contains over 20 million molecules, with the data mainly being integrated from existing databases and partially generated by large language models. Designed…

定量方法 · 定量生物学 2025-03-18 Siyuan Guo , Lexuan Wang , Chang Jin , Jinxian Wang , Han Peng , Huayang Shi , Wengen Li , Jihong Guan , Shuigeng Zhou

Large language models (LLMs) have saturated standard medical benchmarks that test factual recall, yet their ability to perform higher-order reasoning, such as synthesizing evidence from multiple sources, remains critically under-explored.…

计算与语言 · 计算机科学 2026-05-12 Huy Hoang Ha , Benoit Favre , Francois Portet

Large language models offer transformative potential for healthcare, yet their responsible and equitable development depends critically on a deeper understanding of how training data characteristics influence model behavior, including the…

Current medical language model (LM) benchmarks often over-simplify the complexities of day-to-day clinical practice tasks and instead rely on evaluating LMs on multiple-choice board exam questions. In psychiatry especially, these challenges…

Automatic medication mining from clinical and biomedical text has become a popular topic due to its real impact on healthcare applications and the recent development of powerful language models (LMs). However, fully-automatic extraction…

计算与语言 · 计算机科学 2023-08-09 Haifa Alrdahi , Lifeng Han , Hendrik Šuvalov , Goran Nenadic

Large language models (LLMs) have demonstrated broad utility across molecular domains, spanning drug discovery and materials design. Analyzing LLMs' latent representations is crucial for elucidating their underlying mechanisms, improving…

机器学习 · 计算机科学 2026-02-03 Zhuoran Li , Xu Sun , Wanyu Lin , Jiannong Cao

Large language models (LLMs) acquire a breadth of information across various domains. However, their computational complexity, cost, and lack of transparency often hinder their direct application for predictive tasks where privacy and…

机器学习 · 计算机科学 2025-05-29 Alexander Capstick , Rahul G. Krishnan , Payam Barnaghi

In the rapidly evolving landscape of medical imaging diagnostics, achieving high accuracy while preserving computational efficiency remains a formidable challenge. This work presents \texttt{DeepMediX}, a groundbreaking, resource-efficient…

计算机视觉与模式识别 · 计算机科学 2023-07-04 Kishore Babu Nampalle , Pradeep Singh , Uppala Vivek Narayan , Balasubramanian Raman

Large language models can extract local causal claims from text, but those claims become more useful when organized as persistent, navigable world models rather than as flat summaries. We introduce PROMETHEUS, a framework that turns…

人工智能 · 计算机科学 2026-05-14 Sridhar Mahadevan
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