相关论文: Optical Measurement of Mass Density of Biological …
Optical imaging with mechanical contrast is critical for material and biological discovery since it allows contactless light-radiation force-excitation within the sample, as opposed to traditional mechanical imaging. Whilst optical…
Brillouin Light Scattering (BLS) spectroscopy is a non-invasive, non-contact, label-free optical technique that can provide information on the mechanical properties of a material on the sub-micron scale. Over the last decade it has seen…
Brillouin Light Scattering is a powerful technique to measure the microwave excitations present in a magnetic system. In microfocused mode, the light is focused on the sample using a microscope objective. This accelerates substantially the…
Brillouin microscopy is an emerging optical elastography technique that can be used to assess mechanical properties of biological samples in a 3D, all-optical and hence non-contact fashion. However, the low cross-section of spontaneous…
Brillouin microscopy is an emerging technique for all-optical biomechanical imaging without the need for physical contact with the sample or for an external mechanical stimulus. However, Brillouin microscopy often retrieves a single,…
Multicellular systems play a key role in bioprocess and biomedical engineering. Cell ensembles encountered in these setups show phenotypic variability like size and biochemical composition. As this variability may result in undesired…
Non-invasive light scattering methods provide data on biological macromolecules (i.e. proteins, nucleic acids, as well as assemblies and larger entities composed of them) that are complementary with those of size exclusion chromatography,…
We present a method to measure the spectral density of in-band optical transmission impairments without coherent electrical reception and digital signal processing at the receiver. We determine the method's accuracy by numerical simulations…
The role and importance of mechanical properties of cells and tissues in cellular function, development as well as disease has widely been acknowledged, however standard techniques currently used to assess them exhibit intrinsic…
Brillouin spectroscopy and imaging are emerging techniques in analytical science, biophotonics and biomedicine. They are based on Brillouin light scattering from acoustic waves or phonons in the GHz range, providing a nondestructive…
We report an $\textit{in situ}$ mass measurement of approximately-$4.7{\text -}\mu$m-diameter, optically levitated microspheres with an electrostatic co-levitation technique. The mass of a trapped, charged microsphere is measured by holding…
Noncontact label-free biomechanical imaging is a crucial tool for unraveling the mechanical properties of biological systems, which play critical roles in the fields of engineering, physics, biology and medicine; yet, it represents a…
Stimulated Brillouin scattering (SBS) microscopy enables label-free biomechanical imaging, with Brillouin gain serving as a critical contrast parameter for quantitative analysis. However, the influence of sample-induced refractive index…
Brillouin microscopy measures compressibility, but is being increasingly used to assess stiffness of cells and tissues. Using hydrogels with tunable properties, we demonstrate that Brillouin microscopy is insensitive to stiffness of…
Probing forces, deformations and generally speaking the mechanical properties of cells is the hallmark of mechanobiology. In the last two decades many techniques have been developed to this end that are largely based on deforming the cells…
Gravitational microlensing is a robust tool to detect and directly measure the abundance and mass of any kind of compact objects, either in our galaxy or in the extragalatic domain. On basis to generic, broadly applicable arguments, it is…
Characterizing the micromechanical properties of cells and extracellular matrices is critical in mechanobiology. To meet this need, Brillouin light scattering (BLS) has emerged as a noncontact, high-resolution elastography tool that probes…
Non-intrusive quantitative fluid density measurements methods are essential in stratified flow experiments. Digital imaging leads to synthetic Schlieren methods in which the variations of the index of refraction are reconstructed…
Brillouin imaging is increasingly recognized to be a powerful technique that enables non-invasive measurement of the mechanical properties of cells and tissues on a microscopic scale. This provides an unprecedented tool for investigating…
Non-contact measurement of the refractive index and thickness of multilayer biological tissues is of great significance for biomedical applications and can greatly improve medical diagnosis and treatment. In this work, we introduce a…