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Simulation-guided transcranial focused ultrasound therapies rely on estimating skull acoustic properties from pretreatment imaging. Typical clinical resolution (0.5 mm isotropic) cannot resolve bone microstructure, making the acoustic…

医学物理 · 物理学 2025-12-11 Samuel Clinard , Taylor Webb , Henrik Odéen , Dennis L. Parker , Douglas A. Christensen

Transcranial low-intensity focused ultrasound can deliver energy to the brain in a minimally invasive manner for neuromodulation applications. However, continuous sonication through the skull introduces significant wave interactions,…

医学物理 · 物理学 2025-02-07 Han Li , Isla Barnard , Tyler Halliwell , Xinyu Zhang , Andreas Melzer , Zhihong Huang

Background: Individual skull models of bone density and geometry are important when planning the expected transcranial ultrasound acoustic field and estimating mechanical and thermal safety in low-intensity transcranial ultrasound…

Background Resonance frequency analyses and quantitative ultrasound methods have been suggested to assess dental implant primary stability. PurposeThe purpose of this study was to compare the results obtained using these two techniques…

医学物理 · 物理学 2019-05-22 Romain Vayron , Vu Hieu Nguyen , Benoît Lecuelle , Guillaume Haiat

Transcranial ultrasound therapy uses focused acoustic energy to induce therapeutic bioeffects in the brain. Ultrasound must be transmitted through the skull, which is highly attenuating and heterogeneous, causing beam distortion, reducing…

The work describes a numerical method to study the nature of compressive failure of porous ceramics in relation to its volume fraction. The microstructure of an alumina-based foam material manufactured by mechanical stirring of a slurry is…

应用物理 · 物理学 2025-03-13 Vinit Vijay Deshpande , Romana Piat

We propose a 3D neural network with specific loss functions for quantitative computed tomography (QCT) noise reduction to compute micro-structural parameters such as tissue mineral density (TMD) and bone volume ratio (BV/TV) with…

图像与视频处理 · 电气工程与系统科学 2020-11-11 Felix Thomsen , José M. Fuertes García , Manuel Lucena , Juan Pisula , Rodrigo de Luis García , Jan Broggrefe , Claudio Delrieux

High resolution transcranial ultrasound imaging in humans has been a persistent challenge for ultrasound due to the imaging degradation effects from aberration and reverberation. These mechanisms depend strongly on skull morphology and they…

医学物理 · 物理学 2018-11-28 Danai E. Soulioti , David Espíndola , Paul A. Dayton , Gianmarco Pinton

Acoustic impedance mismatches between soft tissues and bones are known to result in strong aberrations in optoacoustic and ultrasound images. Of particular importance are the severe distortions introduced by the human skull, impeding…

医学物理 · 物理学 2021-08-10 Xose Luis Dean-Ben , Daniel Razansky

Transcranial focused ultrasound (tFUS) is a therapeutic ultrasound method that focuses sound through the skull to a small region noninvasively and often under MRI guidance. CT imaging is used to estimate the acoustic properties that vary…

图像与视频处理 · 电气工程与系统科学 2022-10-27 Han Liu , Michelle K. Sigona , Thomas J. Manuel , Li Min Chen , Benoit M. Dawant , Charles F. Caskey

Model-based treatment planning for transcranial ultrasound therapy typically involves mapping the acoustic properties of the skull from an x-ray computed tomography (CT) image of the head. Here, three methods for generating pseudo-CT images…

Objective. While ultrasound is largely established for use in diagnostic imaging and heating therapies, its application for neuromodulation is relatively new and not well understood. The objective of the present study was to investigate…

组织与器官 · 定量生物学 2015-03-09 Jerel K. Mueller , Wynn Legon , William J. Tyler

Degenerative discopathy is a common pathology which may require spine surgery. A metallic cylindrical pin is inserted into the vertebral body to maintain soft tissues and may be used as a reflector of ultrasonic wave to estimate bone…

Transcranial ultrasound applications require accurate simulations to predict intracranial acoustic pressure fields. The current gold standard typically consists of calculating a longitudinal ultrasound wave propagation using a fluid skull…

Intracortical US imaging extends B-mode imaging into bone using a dedicated image reconstruction algorithm that corrects for refraction at the bone-soft tissue interfaces. It has shown promising results in a few healthy, predominantly young…

医学物理 · 物理学 2025-02-14 Amadou S. Dia , Guillaume Renaud , Christine Chappard , Quentin Grimal

Biomedical photoacoustic (PA) imaging is typically used to exploit absorption-based contrast in soft tissue at depths of several centimeters. When it is applied to measuring PA waves generated in the brain, the acoustic properties of the…

医学物理 · 物理学 2023-09-26 Thomas Kirchner , Claus Villringer , Jan Laufer

Ultrasound brain imaging remains challenging due to the large difference in sound speed between the skull and brain tissues and the difficulty of coupling large probes to the skull. This work aims to achieve quantitative transcranial…

计算机视觉与模式识别 · 计算机科学 2025-12-02 Shengyu Chen , Shihang Feng , Yi Luo , Xiaowei Jia , Youzuo Lin

Ultrasound-induced degradation of soft polymeric colloids, like microgels, as well as a controlled drug release enabled by mechanoresponsive bonds, has recently attracted considerable attention. However, most examples in the literature…

The proposed study investigates the damage mechanisms of martensitic stainless steel X3CrNiMo13-4 exposed to cavitation using two complementary experimental apparatus: ultrasonic horn (MUCEF) and hydrodynamic tunnel (PREVERO). Cavitation…

Ultrasound imaging of the cortex of long bones may enable the measurement of the cortical thickness and the ultrasound wave speed in cortical bone tissue. However, with bone loss, the cortical porosity and the size of the pores increase,…

医学物理 · 物理学 2025-07-14 Amadou S. Dia , Quentin Grimal , Guillaume Renaud
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