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Aim: To review how machine learning (ML) is applied to imaging biomarkers in neuro-oncology, in particular for diagnosis, prognosis, and treatment response monitoring. Materials and Methods: The PubMed and MEDLINE databases were searched…

定量方法 · 定量生物学 2019-10-17 Thomas Booth , Matthew Williams , Aysha Luis , Jorge Cardoso , Ashkan Keyoumars , Haris Shuaib

While Large Language Models (LLMs) are emerging as a promising direction in computational pathology, the substantial computational cost of giga-pixel Whole Slide Images (WSIs) necessitates the use of Multi-Instance Learning (MIL) to enable…

计算机视觉与模式识别 · 计算机科学 2025-11-12 Zhenfeng Zhuang , Fangyu Zhou , Liansheng Wang

Recent advances in attention-based multiple instance learning (MIL) have improved our insights into the tissue regions that models rely on to make predictions in digital pathology. However, the interpretability of these approaches is still…

Multiple instance learning is qualified for many pattern recognition tasks with weakly annotated data. The combination of artificial neural network and multiple instance learning offers an end-to-end solution and has been widely utilized.…

计算机视觉与模式识别 · 计算机科学 2022-05-30 Jingjun Yi , Beichen Zhou

Histopathology image analysis is the golden standard of clinical diagnosis for Cancers. In doctors daily routine and computer-aided diagnosis, the Whole Slide Image (WSI) of histopathology tissue is used for analysis. Because of the…

计算机视觉与模式识别 · 计算机科学 2023-11-23 Honglin Li , Yunlong Zhang , Chenglu Zhu , Jiatong Cai , Sunyi Zheng , Lin Yang

Many medical datasets have recently been created for medical image segmentation tasks, and it is natural to question whether we can use them to sequentially train a single model that (1) performs better on all these datasets, and (2)…

计算机视觉与模式识别 · 计算机科学 2022-08-02 Chenyu You , Jinlin Xiang , Kun Su , Xiaoran Zhang , Siyuan Dong , John Onofrey , Lawrence Staib , James S. Duncan

Multiple instance learning (MIL) has shown significant promise in histopathology whole slide image (WSI) analysis for cancer diagnosis and prognosis. However, the inherent spatial heterogeneity of WSIs presents critical challenges, as…

计算机视觉与模式识别 · 计算机科学 2026-01-13 Junjian Li , Jin Liu , Hulin Kuang , Hailin Yue , Mengshen He , Jianxin Wang

Multiple Instance Learning (MIL) methods have become increasingly popular for classifying giga-pixel sized Whole-Slide Images (WSIs) in digital pathology. Most MIL methods operate at a single WSI magnification, by processing all the tissue…

计算机视觉与模式识别 · 计算机科学 2022-07-27 Kevin Thandiackal , Boqi Chen , Pushpak Pati , Guillaume Jaume , Drew F. K. Williamson , Maria Gabrani , Orcun Goksel

Most recently, the pathology diagnosis of cancer is shifting to integrating molecular makers with histology features. It is a urgent need for digital pathology methods to effectively integrate molecular markers with histology, which could…

图像与视频处理 · 电气工程与系统科学 2023-06-28 Xiaofei Wang , Stephen Price , Chao Li

Recent Multimodal Large Language Models (MLLMs) excel in vision-language understanding but face challenges in adapting to dynamic real-world scenarios that require continuous integration of new knowledge and skills. While continual learning…

计算与语言 · 计算机科学 2025-10-02 Hongbo Zhao , Fei Zhu , Haiyang Guo , Meng Wang , Rundong Wang , Gaofeng Meng , Zhaoxiang Zhang

Multi-Instance Learning (MIL) is a recent machine learning paradigm which is immensely useful in various real-life applications, like image analysis, video anomaly detection, text classification, etc. It is well known that most of the…

计算机视觉与模式识别 · 计算机科学 2023-04-18 Yu-Xuan Zhang , Hua Meng , Xue-Mei Cao , Zhengchun Zhou , Mei Yang , Avik Ranjan Adhikary

Instance-incremental learning (IIL) focuses on learning continually with data of the same classes. Compared to class-incremental learning (CIL), the IIL is seldom explored because IIL suffers less from catastrophic forgetting (CF). However,…

机器学习 · 计算机科学 2024-06-06 Qiang Nie , Weifu Fu , Yuhuan Lin , Jialin Li , Yifeng Zhou , Yong Liu , Lei Zhu , Chengjie Wang

Malicious software (malware) classification offers a unique challenge for continual learning (CL) regimes due to the volume of new samples received on a daily basis and the evolution of malware to exploit new vulnerabilities. On a typical…

密码学与安全 · 计算机科学 2022-08-16 Mohammad Saidur Rahman , Scott E. Coull , Matthew Wright

To alleviate the cost of regression testing in continuous integration (CI), a large number of machine learning-based (ML-based) test case prioritization techniques have been proposed. However, it is yet unknown how they perform under the…

软件工程 · 计算机科学 2023-11-23 Yifan Zhao , Dan Hao , Lu Zhang

Continual learning (CL) refers to the ability to continuously learn and accumulate new knowledge while retaining useful information from past experiences. Although numerous CL methods have been proposed in recent years, it is not…

机器学习 · 统计学 2025-03-27 Hanwen Xing , Christopher Yau

Multiple Instance Learning (MIL) methods have succeeded remarkably in histopathology whole slide image (WSI) analysis. However, most MIL models only offer attention-based explanations that do not faithfully capture the model's decision…

计算机视觉与模式识别 · 计算机科学 2025-07-17 Susu Sun , Dominique van Midden , Geert Litjens , Christian F. Baumgartner

Multiple instance learning (MIL) aims to learn the mapping between a bag of instances and the bag-level label. In this paper, we propose a new end-to-end graph neural network (GNN) based algorithm for MIL: we treat each bag as a graph and…

机器学习 · 计算机科学 2019-06-13 Ming Tu , Jing Huang , Xiaodong He , Bowen Zhou

Nuclei instance segmentation on histopathology images is of great clinical value for disease analysis. Generally, fully-supervised algorithms for this task require pixel-wise manual annotations, which is especially time-consuming and…

计算机视觉与模式识别 · 计算机科学 2023-06-06 Yang Zhou , Yongjian Wu , Zihua Wang , Bingzheng Wei , Maode Lai , Jianzhong Shou , Yubo Fan , Yan Xu

Multiple instance learning (MIL) has emerged as a powerful framework for weakly supervised whole slide image (WSI) classification, enabling slide-level predictions without requiring detailed patch-level annotations. Despite its success, a…

计算机视觉与模式识别 · 计算机科学 2025-07-25 Bryan Wong , Mun Yong Yi

Continuous-time reinforcement learning (CTRL) provides a natural framework for sequential decision-making in dynamic environments where interactions evolve continuously over time. While CTRL has shown growing empirical success, its ability…

机器学习 · 计算机科学 2025-12-04 Runze Zhao , Yue Yu , Ruhan Wang , Chunfeng Huang , Dongruo Zhou
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