相关论文: Time-to-Event Modeling with Pseudo-Observations in…

Overfitting, which happens when the number of parameters in a model is too large compared to the number of data points available for determining these parameters, is a serious and growing problem in survival analysis. While modern medicine…

Within-individual variability of health indicators measured over time is becoming commonly used to inform about disease progression. Simple summary statistics (e.g. the standard deviation for each individual) are often used but they are not…

Discrete-time hazard models are widely used when event times are measured in intervals or are not precisely observed. While these models can be estimated using standard generalized linear model techniques, they rely on extensive data…

Time-to-event endpoints are frequently used as outcomes in oncology and other disease areas where the outcome of interest may not be observed within a predetermined period. Although many analytical methods address the challenges of…

We apply Gaussian process (GP) regression, which provides a powerful non-parametric probabilistic method of relating inputs to outputs, to survival data consisting of time-to-event and covariate measurements. In this context, the covariates…

Analyses of time to event datasets have been invariably based on the Cox proportional hazards model (PHM). Reformulations of the PHM as a Poisson Generalized Additive Model (GAM) or as a Generalized Linear Mixed Model (GLMM) have been…

Statistical estimation and inference for marginal hazard models with varying coefficients for multivariate failure time data are important subjects in survival analysis. A local pseudo-partial likelihood procedure is proposed for estimating…

Personalized health analytics increasingly rely on population benchmarks to provide contextual insights such as ''How do I compare to others like me?'' However, cohort-based aggregation of health data introduces nontrivial privacy risks,…

Federated Learning (FL) has recently made significant progress as a new machine learning paradigm for privacy protection. Due to the high communication cost of traditional FL, one-shot federated learning is gaining popularity as a way to…

In biomedical studies it is common to collect data on multiple biomarkers during study follow-up for dynamic prediction of a time-to-event clinical outcome. The biomarkers are typically intermittently measured, missing at some event times,…

This paper addresses the challenge of preserving privacy in Federated Learning (FL) within centralized systems, focusing on both trusted and untrusted server scenarios. We analyze this setting within the Stochastic Convex Optimization (SCO)…

We use statistical mechanics techniques, viz. the replica method, to model the effect of censoring on overfitting in Cox's proportional hazards model, the dominant regression method for time-to-event data. In the overfitting regime, Maximum…

Calibrating machine learning models so that predicted probabilities better reflect the true outcome frequencies is crucial for reliable decision-making across many applications. In Federated Learning (FL), the goal is to train a global…

Developing accurate and generalizable epileptic seizure prediction models from electroencephalography (EEG) data across multiple clinical sites is hindered by patient privacy regulations and significant data heterogeneity (non-IID…

Models for predicting the risk of cardiovascular events based on individual patient characteristics are important tools for managing patient care. Most current and commonly used risk prediction models have been built from carefully selected…

Spatial data are central to applications such as environmental monitoring and urban planning, but are often distributed across devices where privacy and communication constraints limit direct sharing. Federated modeling offers a practical…

Optimization-based techniques for federated learning (FL) often come with prohibitive communication cost, as high dimensional model parameters need to be communicated repeatedly between server and clients. In this paper, we follow a…

Bayesian inference for survival regression modeling offers numerous advantages, especially for decision-making and external data borrowing, but demands the specification of the baseline hazard function, which may be a challenging task. We…

In the era of big data, leveraging information from multiple clients while preserving data privacy has emerged as a critical challenge in modern statistical modeling and forecasting. This paper introduces a privacy-preserving federated…

Federated or multi-site studies have distinct advantages over single-site studies, including increased generalizability, the ability to study underrepresented populations, and the opportunity to study rare exposures and outcomes. However,…