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Radiotherapy can effectively kill malignant cells, but the doses required to cure cancer patients may inflict severe collateral damage to adjacent healthy tissues. Hyperthermia (HT) is a promising option to improve the outcome of radiation…

We develop a multiphysics-based model to predict the response of localized tumors to combined-hyperthermia-radiotherapy (CHR) treatment. This procedure combines hyperthermia (tumor heating) with standard radiotherapy to improve efficacy of…

组织与器官 · 定量生物学 2019-07-05 Japan K. Patel , Richard Vasques , Barry D. Ganapol

Hyperthermia (HT) in combination with radio- and/or chemotherapy has become an accepted cancer treatment for distinct solid tumour entities. In HT, tumour tissue is exogenously heated to temperatures between 39 and 43 $^\circ$C for 60…

Multimodal oncological strategies which combine chemotherapy or radiotherapy with hyperthermia have a potential of improving the efficacy of the non-surgical methods of cancer treatment. Hyperthermia engages the heat-shock response…

亚细胞过程 · 定量生物学 2013-09-05 Mikołaj Rybiński , Zuzanna Szymańska , Sławomir Lasota , Anna Gambin

During laser and ultrasound thermotherapy it is always desirable to have a precise necrosis of deeply seated tumor preserving the adjoining healthy tissue with minimum thermally induced nociceptive pain sensation to the patient. The aim of…

医学物理 · 物理学 2020-07-29 Abhijit Paul , Anup Paul

Magnetic hyperthermia is a new type of cancer treatment designed for overcoming resistance to chemotherapy during the treatment of solid, inaccessible human tumors. The main challenge of this technology is increasing the local tumoral…

We report the enhanced optical transmission in the coherent, off-resonant excitation of Rydberg atom gases at room temperature via a two-photon process. Here thermal resonance-enhanced transparency (TRET) is induced when the detuning of the…

The high-temperature ratio (HTR) is a parameter quantifying changes of the shape of the high-temperature part of the LiF:Mg,Ti glow-curve after exposure to densely ionizing radiation. It was introduced in order to estimate the effective LET…

仪器与探测器 · 物理学 2014-02-28 P. Bilski , M. Sadel , J. Swakon , A. Weber

Proteins can be regarded as thermal nanosensors in an intra-body network. Upon being stimulated by Terahertz (THz) frequencies that match their vibrational modes, protein molecules experience resonant absorption and dissipate their energy…

分子网络 · 定量生物学 2024-07-01 Hadeel Elayan , Samar Elmaadawy , Andrew W. Eckford , Raviraj Adve , Josep Jornet

Hyperthermia therapy (HT) is used to treat diseases through heating of high temperature usually in conjunction with some other medical therapeutics like chemotherapy and radiotherapy. In this study, we propose a promising thermostatic…

医学物理 · 物理学 2021-09-14 Yuchan Wang , Yuening Wang , Yuan Jie , Paul Carson

Microwave hyperthermia aims at selectively heating cancer cells to a supra-physiological temperature. For non-superficial tumors, this can be achieved by means of an antenna array equipped with a proper cooling system (the water bolus) to…

计算工程、金融与科学 · 计算机科学 2020-12-15 Rossella Gaffoglio , Marco Righero , Giorgio Giordanengo , Marcello Zucchi , Giuseppe Vecchi

Therapies such as combined-hyperthermia-radiotherapy (CHR) take advantage of excellent radiosensitization properties of hyperthermia and treat of tumors with both radiation and heat. To appropriately model a CHR treatment, features like…

组织与器官 · 定量生物学 2020-05-14 Japan K. Patel , John J. Kuczek , Richard Vasques

This paper presents a comprehensive computer simulation of thermal processes in multilayered biological tissues for the analysis of luminance temperature distributions recorded by microwave radiometry. A mathematical model combining the…

生物物理 · 物理学 2025-10-21 Maxim V. Polyakov , Illarion E. Popov

A simplified 2-D model which is an example of regional RF hyperthermia is presented. Human body is inside the wire with exciting current and the electromagnetic energy is concentrated within the tumor. The analyzed model is therefore a…

医学物理 · 物理学 2017-10-31 Piotr Gas

This study was undertaken to develop a system for heat transfer simulation for optimization and treatment planning of magnetic hyperthermia treatment (MHT) using magnetic particle imaging (MPI). First, we performed phantom experiments to…

医学物理 · 物理学 2016-05-27 Natsuo Banura , Atsushi Mimura , Kohei Nishimoto , Kenya Murase

We study the use of a thermoelectric junction as a thermal radiation detector in the calorimetric regime, where single radiation bursts can be separated in time domain. We focus especially on the case of a large thermoelectric figure of…

介观与纳米尺度物理 · 物理学 2018-10-17 Subrata Chakraborty , Tero T. Heikkilä

Mechanical algesia is an important process for the preservation of living organisms, allowing potentially life-saving reflexes or decisions when given body parts are stressed. Yet, its various underlying mechanisms remain to be fully…

生物物理 · 物理学 2021-02-09 Tom Vincent-Dospital , Renaud Toussaint

Evaluating impact-induced damage in composite materials under varying temperature conditions is essential for ensuring structural integrity and reliable performance in aerospace, polar, and other extreme-environment applications. As matrix…

By extending the classical Peyrard-Bishop model, we are able to obtain a fully analytical description for the mechanical resistance of DNA under stretching at variable values of temperature, number of base pairs and intrachains and…

软凝聚态物质 · 物理学 2022-07-20 G. Florio , G. Puglisi

DNA hybridization is a fundamental reaction with wide-ranging applications in biotechnology. The nearest-neighbor (NN) model provides the most reliable description of the energetics of duplex formation. Most DNA thermodynamics studies have…

生物大分子 · 定量生物学 2024-04-30 Paolo Rissone , Marc Rico-Pasto , Steve Smith , Felix Ritort
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