相关论文: Multi-Disease Deep Learning Framework for GWAS: Be…

It has been shown that deep learning models can under certain circumstances outperform traditional statistical methods at forecasting. Furthermore, various techniques have been developed for quantifying the forecast uncertainty (prediction…

The automated management of invasive weeds is critical for sustainable agriculture, yet the performance of deep learning models in real-world fields is often compromised by two factors: challenging environmental conditions and the high cost…

Progress in probabilistic generative models has accelerated, developing richer models with neural architectures, implicit densities, and with scalable algorithms for their Bayesian inference. However, there has been limited progress in…

The composition of multiple Gaussian Processes as a Deep Gaussian Process (DGP) enables a deep probabilistic nonparametric approach to flexibly tackle complex machine learning problems with sound quantification of uncertainty. Existing…

In this paper, we tackle the problem of convolutional neural network design. Instead of focusing on the design of the overall architecture, we investigate a design space that is usually overlooked, i.e. adjusting the channel configurations…

Diagnosis and risk stratification of cancer and many other diseases require the detection of genomic breakpoints as a prerequisite of calling copy number alterations (CNA). This, however, is still challenging and requires time-consuming…

State-of-the-art, high capacity deep neural networks not only require large amounts of labelled training data, they are also highly susceptible to label errors in this data, typically resulting in large efforts and costs and therefore…

Recent advancements in semi-supervised deep learning have introduced effective strategies for leveraging both labeled and unlabeled data to improve classification performance. This work proposes a semi-supervised framework that utilizes a…

Image denoising plays a critical role in biomedical and microscopy imaging, especially when acquiring wide-field fluorescence-stained images. This task faces challenges in multiple fronts, including limitations in image acquisition…

Plant disease is a critical factor affecting agricultural production. Traditional manual recognition methods face significant drawbacks, including low accuracy, high costs, and inefficiency. Deep learning techniques have demonstrated…

Recent advances in deep learning (DL) have prompted the development of high-performing early warning score (EWS) systems, predicting clinical deteriorations such as acute kidney injury, acute myocardial infarction, or circulatory failure.…

Merging the two cultures of deep and statistical learning provides insights into structured high-dimensional data. Traditional statistical modeling is still a dominant strategy for structured tabular data. Deep learning can be viewed…

The choice of parameters, and the design of the network architecture are important factors affecting the performance of deep neural networks. Genetic Algorithms (GA) have been used before to determine parameters of a network. Yet, GAs…

The interpretability of deep learning is crucial for evaluating the reliability of medical imaging models and reducing the risks of inaccurate patient recommendations. This study addresses the "human out of the loop" and "trustworthiness"…

Gene-disease associations are fundamental for understanding disease etiology and developing effective interventions and treatments. Identifying genes not yet associated with a disease due to a lack of studies is a challenging task in which…

Large-scale genome-wide association studies (GWAS) have offered an exciting opportunity to discover putative causal genes or risk factors associated with diseases by using SNPs as instrumental variables (IVs). However, conventional…

Ensemble learning use multiple algorithms to obtain better predictive performance than any single one of its constituent algorithms could. With growing popularity of deep learning, researchers have started to ensemble them for various…

Causal discovery in multi-omic datasets is crucial for understanding the bigger picture of gene regulatory mechanisms, but remains challenging due to high dimensionality, differentiation of direct from indirect relationships, and hidden…

In genome-wide association studies (GWASs), there is an increasing need for detecting the associations between a genetic variant and multiple traits. In studies of complex diseases, it is common to measure several potentially correlated…

Current pharmaceutical formulation development still strongly relies on the traditional trial-and-error approach by individual experiences of pharmaceutical scientists, which is laborious, time-consuming and costly. Recently, deep learning…