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Disease progression modeling (DPM) using longitudinal data is a challenging machine learning task. Existing DPM algorithms neglect temporal dependencies among measurements, make parametric assumptions about biomarker trajectories, do not…

计算机视觉与模式识别 · 计算机科学 2019-03-19 Mostafa Mehdipour Ghazi , Mads Nielsen , Akshay Pai , M. Jorge Cardoso , Marc Modat , Sebastien Ourselin , Lauge Sørensen

Transfer learning has been widely utilized to mitigate the data scarcity problem in the field of Alzheimer's disease (AD). Conventional transfer learning relies on re-using models trained on AD-irrelevant tasks such as natural image…

图像与视频处理 · 电气工程与系统科学 2023-04-18 Kai Tzu-iunn Ong , Hana Kim , Minjin Kim , Jinseong Jang , Beomseok Sohn , Yoon Seong Choi , Dosik Hwang , Seong Jae Hwang , Jinyoung Yeo

Alzheimer's Disease (AD) is characterized by a cascade of biomarkers becoming abnormal, the pathophysiology of which is very complex and largely unknown. Event-based modeling (EBM) is a data-driven technique to estimate the sequence in…

机器学习 · 计算机科学 2019-08-14 Vikram Venkatraghavan , Esther E. Bron , Wiro J. Niessen , Stefan Klein

Alzheimer's disease (AD) is characterized by complex and largely unknown progression dynamics affecting the brain's morphology. Although the disease evolution spans decades, to date we cannot rely on long-term data to model the pathological…

应用统计 · 统计学 2019-08-14 Clement Abi Nader , Nicholas Ayache , Philippe Robert , Marco Lorenzi

Medium-horizon Alzheimer's disease progression prediction is difficult because future clinical scores can remain tied to baseline severity, while biomarker histories are irregular and incompletely observed. We develop an anchor-based…

机器学习 · 计算机科学 2026-05-19 Ran Tong , Tong Wang , Lanruo Wang , Yin Ni

Introduction: It is challenging at baseline to predict when and which individuals who meet criteria for mild cognitive impairment (MCI) will ultimately progress to Alzheimer's disease (AD) dementia. Methods: A deep learning method is…

计算机视觉与模式识别 · 计算机科学 2019-04-17 Hongming Li , Mohamad Habes , David A. Wolk , Yong Fan

Alzheimer's Disease is the most common cause of dementia. Accurate diagnosis and prognosis of this disease are essential to design an appropriate treatment plan, increasing the life expectancy of the patient. Intense research has been…

图像与视频处理 · 电气工程与系统科学 2023-01-05 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé

Disease progression modeling (DPM) using longitudinal data is a challenging task in machine learning for healthcare that can provide clinicians with better tools for diagnosis and monitoring of disease. Existing DPM algorithms neglect…

计算机视觉与模式识别 · 计算机科学 2018-08-17 Mostafa Mehdipour Ghazi , Mads Nielsen , Akshay Pai , M. Jorge Cardoso , Marc Modat , Sebastien Ourselin , Lauge Sørensen

Pattern recognition methods using neuroimaging data for the diagnosis of Alzheimer's disease have been the subject of extensive research in recent years. In this paper, we use deep learning methods, and in particular sparse autoencoders and…

计算机视觉与模式识别 · 计算机科学 2015-02-10 Adrien Payan , Giovanni Montana

Accurate predictions of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) can enable effective personalized therapy. While cognitive tests and clinical data are routinely collected, they lack the predictive power…

机器学习 · 计算机科学 2025-11-11 Richard Hou , Shengpu Tang , Wei Jin

With the global population aging rapidly, Alzheimer's disease (AD) is particularly prominent in older adults, which has an insidious onset and leads to a gradual, irreversible deterioration in cognitive domains (memory, communication,…

音频与语音处理 · 电气工程与系统科学 2023-03-15 Jinchao Li , Kaitao Song , Junan Li , Bo Zheng , Dongsheng Li , Xixin Wu , Xunying Liu , Helen Meng

Objective Alzheimer disease (AD) is the most common cause of dementia, a syndrome characterized by cognitive impairment severe enough to interfere with activities of daily life. We aimed to conduct a systematic literature review (SLR) of…

定量方法 · 定量生物学 2021-08-31 Sayantan Kumar , Inez Oh , Suzanne Schindler , Albert M Lai , Philip R O Payne , Aditi Gupta

Fusing structural-functional images of the brain has shown great potential to analyze the deterioration of Alzheimer's disease (AD). However, it is a big challenge to effectively fuse the correlated and complementary information from…

图像与视频处理 · 电气工程与系统科学 2023-10-06 Qiankun Zuo , Junren Pan , Shuqiang Wang

Alzheimer's Disease (AD) is a progressive neurodegenerative condition that adversely affects cognitive abilities. Language-related changes can be automatically identified through the analysis of outputs from linguistic assessment tasks,…

Objectives: The objectives of this narrative review are to summarize the current state of AI applications in neuroimaging for early Alzheimer's disease (AD) prediction and to highlight the potential of AI techniques in improving early AD…

机器学习 · 计算机科学 2024-06-27 Thorsten Rudroff , Oona Rainio , Riku Klén

Alzheimer's Disease (AD) is one of the most concerned neurodegenerative diseases. In the last decade, studies on AD diagnosis attached great significance to artificial intelligence (AI)-based diagnostic algorithms. Among the diverse…

计算机视觉与模式识别 · 计算机科学 2019-08-20 Yechong Huang , Jiahang Xu , Yuncheng Zhou , Tong Tong , Xiahai Zhuang , the Alzheimer's Disease Neuroimaging Initiative

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease; yet its currently available treatments are limited to stopping disease progression. Moreover, effectiveness of these treatments is not guaranteed due to the…

机器学习 · 计算机科学 2024-02-02 Diego Machado Reyes , Hanqing Chao , Juergen Hahn , Li Shen , Pingkun Yan

Reliable detection of the prodromal stages of Alzheimer's disease (AD) remains difficult even today because, unlike other neurocognitive impairments, there is no definitive diagnosis of AD in vivo. In this context, existing research has…

机器学习 · 计算机科学 2021-08-03 Amish Mittal , Sourav Sahoo , Arnhav Datar , Juned Kadiwala , Hrithwik Shalu , Jimson Mathew

Early and accurate detection of Alzheimer's disease (AD) is crucial for enabling timely intervention and improving outcomes. However, developing reliable machine learning (ML) models for AD diagnosis is challenging due to limited labeled…

机器学习 · 计算机科学 2025-11-27 Abolfazl Moslemi , Hossein Peyvandi

Collecting and accessing a large amount of medical data is very time-consuming and laborious, not only because it is difficult to find specific patients but also because it is required to resolve the confidentiality of a patient's medical…

声音 · 计算机科学 2021-03-04 Junghyun Koo , Jie Hwan Lee , Jaewoo Pyo , Yujin Jo , Kyogu Lee