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Mediation analysis breaks down the causal effect of a treatment on an outcome into an indirect effect, acting through a third group of variables called mediators, and a direct effect, operating through other mechanisms. Mediation analysis…

应用统计 · 统计学 2025-05-13 Judith Abécassis , Houssam Zenati , Sami Boumaïza , Julie Josse , Bertrand Thirion

Causal effect identification considers whether an interventional probability distribution can be uniquely determined from a passively observed distribution in a given causal structure. If the generating system induces context-specific…

人工智能 · 计算机科学 2024-07-03 Santtu Tikka , Antti Hyttinen , Juha Karvanen

Mediation analysis has been used in many disciplines to explain the mechanism or process that underlies an observed relationship between an exposure variable and an outcome variable via the inclusion of mediators. Decompositions of the…

统计方法学 · 统计学 2020-08-03 Xin Gao , Li Li , Li Luo

In mediation analysis, the effect of an exposure (or treatment) on an outcome variable is decomposed into two components: a direct effect, which pertains to an immediate influence of the exposure on the outcome, and an indirect effect,…

统计方法学 · 统计学 2017-10-04 Marco Geraci , Alessandra Mattei

In many applications of causal inference, the treatment received by one unit may influence the outcome of another, a phenomenon referred to as interference. Although there are several frameworks for conducting causal inference in the…

统计方法学 · 统计学 2025-11-27 Matvey Ortyashov , AmirEmad Ghassami

Estimating conditional means using only the marginal means available from aggregate data is commonly known as the ecological inference problem (EI). We provide a reassessment of EI, including a new formalization of identification conditions…

应用统计 · 统计学 2026-01-13 Shiro Kuriwaki , Cory McCartan

Defining the Inclusion/Exclusion (I/E) criteria of a trial is one of the most important steps during a trial design. Increasingly complex I/E criteria potentially create information imbalance and transparency issues between the people who…

应用统计 · 统计学 2020-01-08 Junshui Ma , Daniel J. Holder

Causal mediation analysis is an important statistical method in social and medical studies, as it can provide insights about why an intervention works and inform the development of future interventions. Currently, most causal mediation…

统计方法学 · 统计学 2016-01-26 Cheng Zheng , David C. Atkins , Melissa A. Lewis , Xiao-Hua Zhou

Mediation analysis is critical to understanding the mechanisms underlying exposure-outcome relationships. In this paper, we identify the instrumental variable (IV)-direct effect of the exposure on the outcome not through the mediator, using…

统计方法学 · 统计学 2020-06-16 Kara E Rudolph , Oleg Sofrygin , Mark J van der Laan

Uncertainty quantification for individual treatment effects (ITEs) is a daunting challenge in causal inference. Motivated by recent advances in conformal prediction, several works aim to construct distribution-free prediction sets for ITEs…

统计方法学 · 统计学 2026-05-07 Chongguang Tao , Zheng Zhou , Yuhong Yang

This paper provides robust estimators and efficient inference of causal effects involving multiple interacting mediators. Most existing works either impose a linear model assumption among the mediators or are restricted to handle…

统计方法学 · 统计学 2024-01-12 Haoyu Wei , Hengrui Cai , Chengchun Shi , Rui Song

The practical damage of silicon bipolar devices subjected to mixed ionization and displacement irradiations is usually evaluated by the sum of separated ionization and displacement damages. However, recent experiments show clear difference…

应用物理 · 物理学 2022-02-01 Yu Song , Su-Huai Wei

Causal mediation analysis aims at disentangling a treatment effect into an indirect mechanism operating through an intermediate outcome or mediator, as well as the direct effect of the treatment on the outcome of interest. However, the…

计量经济学 · 经济学 2020-05-05 Martin Huber , Lukáš Lafférs

Information theoretic (IT) approaches to quantifying causal influences have experienced some popularity in the literature, in both theoretical and applied (e.g. neuroscience and climate science) domains. While these causal measures are…

信息论 · 计算机科学 2020-08-26 Gabriel Schamberg , William Chapman , Shang-Ping Xie , Todd P. Coleman

Understanding the pathways whereby an intervention has an effect on an outcome is a common scientific goal. A rich body of literature provides various decompositions of the total intervention effect into pathway specific effects.…

统计方法学 · 统计学 2020-01-20 David Benkeser

Mediation analysis, which started with Baron and Kenny (1986), is used extensively by applied researchers. Indirect and direct effects are the part of a treatment effect that is mediated by a covariate and the part that is not. Subsequent…

统计方法学 · 统计学 2020-12-17 Judith J. Lok , Ronald J. Bosch

Instrumental variable methods provide a powerful approach to estimating causal effects in the presence of unobserved confounding. But a key challenge when applying them is the reliance on untestable "exclusion" assumptions that rule out any…

统计方法学 · 统计学 2020-06-23 Jason Hartford , Victor Veitch , Dhanya Sridhar , Kevin Leyton-Brown

Causal mediation analysis seeks to determine whether an independent variable affects a response variable directly or whether it does so indirectly, by way of a mediator. The existing statistical tests to determine the existence of an…

统计方法学 · 统计学 2023-09-28 John Kidd , Dan-Yu Lin

Causal mediation analysis decomposes the total effect of a treatment on an outcome into the indirect effect, operating through the mediator, and the direct effect, operating through other pathways. One can estimate only the pure indirect…

应用统计 · 统计学 2025-07-16 Vindyani Herath , Ronald J. Bosch , Judith J. Lok

We propose a novel approach for causal mediation analysis based on changes-in-changes assumptions restricting unobserved heterogeneity over time. This allows disentangling the causal effect of a binary treatment on a continuous outcome into…

计量经济学 · 经济学 2020-10-13 Martin Huber , Mark Schelker , Anthony Strittmatter