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Single-cell RNA sequencing (scRNA-seq) enables the study of cellular heterogeneity. Yet, clustering accuracy, and with it downstream analyses based on cell labels, remain challenging due to measurement noise and biological variability. In…

机器学习 · 计算机科学 2026-03-03 Dominik Meier , Shixing Yu , Sagnik Nandy , Promit Ghosal , Kyra Gan

Recently, it has been shown that investing computing resources in searching for good initial noise for a text-to-image diffusion model helps improve performance. However, previous studies required external models to evaluate the resulting…

计算机视觉与模式识别 · 计算机科学 2025-06-17 Changhyun Choi , Sungha Kim , H. Jin Kim

Controlling the spatial and semantic structure of diffusion-generated images remains a challenge. Existing methods like ControlNet rely on handcrafted condition maps and retraining, limiting flexibility and generalization. Inversion-based…

计算机视觉与模式识别 · 计算机科学 2025-11-10 Jiang Lin , Xinyu Chen , Song Wu , Zhiqiu Zhang , Jizhi Zhang , Ye Wang , Qiang Tang , Qian Wang , Jian Yang , Zili Yi

Diffusion models have achieved remarkable success in generative modeling. However, this study confirms the existence of overfitting in diffusion model training, particularly in data-limited regimes. To address this challenge, we propose…

机器学习 · 计算机科学 2025-08-12 Liang Hou , Yuan Gao , Boyuan Jiang , Xin Tao , Qi Yan , Renjie Liao , Pengfei Wan , Di Zhang , Kun Gai

Discrete diffusion models have recently emerged as strong alternatives to autoregressive language models, matching their performance through large-scale training. However, inference-time control remains relatively underexplored. In this…

机器学习 · 计算机科学 2026-04-09 Meihua Dang , Jiaqi Han , Minkai Xu , Kai Xu , Akash Srivastava , Stefano Ermon

Constrained decoding enables Language Models (LMs) to produce samples that provably satisfy hard constraints. However, existing constrained-decoding approaches often distort the underlying model distribution, a limitation that is especially…

Denoising diffusions are state-of-the-art generative models exhibiting remarkable empirical performance. They work by diffusing the data distribution into a Gaussian distribution and then learning to reverse this noising process to obtain…

机器学习 · 统计学 2024-02-20 Joe Benton , Yuyang Shi , Valentin De Bortoli , George Deligiannidis , Arnaud Doucet

We address the challenge of training diffusion models to sample from unnormalized energy distributions in the absence of data, the so-called diffusion samplers. Although these approaches have shown promise, they struggle to scale in more…

机器学习 · 计算机科学 2025-11-07 Minkyu Kim , Kiyoung Seong , Dongyeop Woo , Sungsoo Ahn , Minsu Kim

Classifier-Free Guidance (CFG) is a widely used technique for improving conditional diffusion models by linearly combining the outputs of conditional and unconditional denoisers. While CFG enhances visual quality and improves alignment with…

机器学习 · 计算机科学 2025-05-28 Badr Moufad , Yazid Janati , Alain Durmus , Ahmed Ghorbel , Eric Moulines , Jimmy Olsson

We present a novel generative approach based on Denoising Diffusion Models (DDMs), which produces high-quality image samples along with their losslessly compressed bit-stream representations. This is obtained by replacing the standard…

图像与视频处理 · 电气工程与系统科学 2025-07-29 Guy Ohayon , Hila Manor , Tomer Michaeli , Michael Elad

We study the problem of training diffusion and flow generative models to sample from target distributions defined by an exponential tilting of a base density; a formulation that subsumes both sampling from unnormalized densities and reward…

机器学习 · 统计学 2026-05-04 Carles Domingo-Enrich , Yuanqi Du , Michael S. Albergo

Denoising Score Matching estimates the score of a noised version of a target distribution by minimizing a regression loss and is widely used to train the popular class of Denoising Diffusion Models. A well known limitation of Denoising…

机器学习 · 计算机科学 2024-02-14 Valentin De Bortoli , Michael Hutchinson , Peter Wirnsberger , Arnaud Doucet

Aligning diffusion model outputs with downstream objectives is essential for improving task-specific performance. Broadly, inference-time training-free approaches for aligning diffusion models can be categorized into two main strategies:…

计算机视觉与模式识别 · 计算机科学 2025-12-16 Maurya Goyal , Anuj Singh , Hadi Jamali-Rad

Diffusion models have achieved remarkable success in generating high-fidelity content but suffer from slow, iterative sampling, resulting in high latency that limits their use in interactive applications. We introduce DRiffusion, a parallel…

机器学习 · 计算机科学 2026-03-30 Runsheng Bai , Chengyu Zhang , Yangdong Deng

Diffusion Probabilistic Models have demonstrated remarkable performance across a wide range of generative tasks. However, we have observed that these models often suffer from a Signal-to-Noise Ratio-timestep (SNR-t) bias. This bias refers…

计算机视觉与模式识别 · 计算机科学 2026-04-20 Meng Yu , Lei Sun , Jianhao Zeng , Xiangxiang Chu , Kun Zhan

Discrete Diffusion and Flow Matching models have significantly advanced generative modeling for discrete structures, including graphs. However, the dependencies between intermediate noisy states lead to error accumulation and propagation…

机器学习 · 计算机科学 2025-06-24 Yoann Boget

Inference-time scaling has achieved remarkable success in language models, yet its adaptation to diffusion models remains underexplored. We observe that the efficacy of recent Sequential Monte Carlo (SMC)-based methods largely stems from…

机器学习 · 计算机科学 2025-08-19 Xun Su , Jianming Huang , Yang Yusen , Zhongxi Fang , Hiroyuki Kasai

Aligning diffusion models with user preferences has been a key challenge. Existing methods for aligning diffusion models either require retraining or are limited to differentiable reward functions. To address these limitations, we propose a…

计算机视觉与模式识别 · 计算机科学 2025-02-28 Po-Hung Yeh , Kuang-Huei Lee , Jun-Cheng Chen

Sampling-based search, a simple paradigm for utilizing test-time compute, involves generating multiple candidate responses and selecting the best one -- typically by having models self-verify each response for correctness. In this paper, we…

机器学习 · 计算机科学 2025-02-21 Eric Zhao , Pranjal Awasthi , Sreenivas Gollapudi

Guided diffusion sampling relies on approximating often intractable likelihood scores, which introduces significant noise into the sampling dynamics. We propose using adaptive moment estimation to stabilize these noisy likelihood scores…

机器学习 · 计算机科学 2026-04-24 Christian Belardi , Justin Lovelace , Kilian Q. Weinberger , Carla P. Gomes