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Large Language Models (LLMs) are transforming scientific hypothesis generation and validation by enabling information synthesis, latent relationship discovery, and reasoning augmentation. This survey provides a structured overview of…

Hypothesis generation is a fundamental step in scientific discovery, yet it is increasingly challenged by information overload and disciplinary fragmentation. Recent advances in Large Language Models (LLMs) have sparked growing interest in…

Inductive reasoning is a core problem-solving capacity: humans can identify underlying principles from a few examples, which robustly generalize to novel scenarios. Recent work evaluates large language models (LLMs) on inductive reasoning…

机器学习 · 计算机科学 2024-06-03 Ruocheng Wang , Eric Zelikman , Gabriel Poesia , Yewen Pu , Nick Haber , Noah D. Goodman

Effective generation of novel hypotheses is instrumental to scientific progress. So far, researchers have been the main powerhouse behind hypothesis generation by painstaking data analysis and thinking (also known as the Eureka moment). In…

人工智能 · 计算机科学 2024-12-20 Yangqiaoyu Zhou , Haokun Liu , Tejes Srivastava , Hongyuan Mei , Chenhao Tan

Large language models (LLMs) increasingly help people solve problems, from debugging code to repairing machinery. This process requires generating plausible hypotheses from partial descriptions, then updating them as more information…

机器学习 · 计算机科学 2026-05-08 Hua-Dong Xiong

AI holds promise for transforming scientific processes, including hypothesis generation. Prior work on hypothesis generation can be broadly categorized into theory-driven and data-driven approaches. While both have proven effective in…

人工智能 · 计算机科学 2025-01-10 Haokun Liu , Yangqiaoyu Zhou , Mingxuan Li , Chenfei Yuan , Chenhao Tan

Large Language Models (LLMs) show impressive inductive reasoning capabilities, enabling them to generate hypotheses that could generalize effectively to new instances when guided by in-context demonstrations. However, in real-world…

人工智能 · 计算机科学 2024-12-19 Zhuo Liu , Ding Yu , Hangfeng He

Since the advent of Large Language Models (LLMs), efforts have largely focused on improving their instruction-following and deductive reasoning abilities, leaving open the question of whether these models can truly discover new knowledge.…

计算与语言 · 计算机科学 2025-10-31 Kaiyu He , Zhiyu Chen

Large language models (LLMs) have shown significant potential in scientific disciplines such as biomedicine, particularly in hypothesis generation, where they can analyze vast literature, identify patterns, and suggest research directions.…

Large language models (LLMs) have demonstrated great potential for automating the evaluation of natural language generation. Previous frameworks of LLM-as-a-judge fall short in two ways: they either use zero-shot setting without consulting…

计算与语言 · 计算机科学 2025-04-11 Mingxuan Li , Hanchen Li , Chenhao Tan

Hypothesis formulation and testing are central to empirical research. A strong hypothesis is a best guess based on existing evidence and informed by a comprehensive view of relevant literature. However, with exponential increase in the…

计算与语言 · 计算机科学 2024-03-27 Sai Koneru , Jian Wu , Sarah Rajtmajer

The rapid growth of biomedical knowledge has outpaced our ability to efficiently extract insights and generate novel hypotheses. Large language models (LLMs) have emerged as a promising tool to revolutionize knowledge interaction and…

计算与语言 · 计算机科学 2024-07-16 Biqing Qi , Kaiyan Zhang , Kai Tian , Haoxiang Li , Zhang-Ren Chen , Sihang Zeng , Ermo Hua , Hu Jinfang , Bowen Zhou

Inductive Logic Programming (ILP) is a principled approach for generalizing regularities from data and constructing hypotheses as interpretable logic programs. However, a key limitation is its reliance on expert-crafted language bias - the…

人工智能 · 计算机科学 2026-01-21 Yang Yang , Jiemin Wu , Yutao Yue

Integrating free-text explanations to in-context learning of large language models (LLM) is shown to elicit strong reasoning capabilities along with reasonable explanations. In this paper, we consider the problem of leveraging the…

计算与语言 · 计算机科学 2022-10-14 Shiyang Li , Jianshu Chen , Yelong Shen , Zhiyu Chen , Xinlu Zhang , Zekun Li , Hong Wang , Jing Qian , Baolin Peng , Yi Mao , Wenhu Chen , Xifeng Yan

Significant scientific discoveries have driven the progress of human civilisation. The explosion of scientific literature and data has created information barriers across disciplines that have slowed the pace of scientific discovery. Large…

计算与语言 · 计算机科学 2023-11-13 Biqing Qi , Kaiyan Zhang , Haoxiang Li , Kai Tian , Sihang Zeng , Zhang-Ren Chen , Bowen Zhou

Contemporary automated scientific discovery has focused on agents for generating scientific experiments, while systems that perform higher-level scientific activities such as theory building remain underexplored. In this work, we formulate…

计算与语言 · 计算机科学 2026-04-10 Peter Jansen , Peter Clark , Doug Downey , Daniel S. Weld

Despite the dramatic progress in Large Language Model (LLM) development, LLMs often provide seemingly plausible but not factual information, often referred to as hallucinations. Retrieval-augmented LLMs provide a non-parametric approach to…

计算与语言 · 计算机科学 2023-11-09 Sai Munikoti , Anurag Acharya , Sridevi Wagle , Sameera Horawalavithana

Alignment algorithms are widely used to align large language models (LLMs) to human users based on preference annotations. Typically these (often divergent) preferences are aggregated over a diverse set of users, resulting in fine-tuned…

计算与语言 · 计算机科学 2025-05-21 Cristina Garbacea , Chenhao Tan

Combining different forms of prompts with pre-trained large language models has yielded remarkable results on reasoning tasks (e.g. Chain-of-Thought prompting). However, along with testing on more complex reasoning, these methods also…

计算与语言 · 计算机科学 2024-05-14 Yitian Li , Jidong Tian , Hao He , Yaohui Jin

Logical reasoning is a core challenge in natural language understanding and a fundamental capability of artificial intelligence, underpinning scientific discovery, mathematical theorem proving, and complex decision-making. Despite the…

计算与语言 · 计算机科学 2025-12-04 Qingchuan Li , Mingyue Cheng , Zirui Liu , Daoyu Wang , Yuting Zeng , Tongxuan Liu
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