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The ability to accurately predict disease progression is paramount for optimizing multiple myeloma patient care. This study introduces a hybrid neural network architecture, combining Long Short-Term Memory networks with a Conditional…

With increasing interest in adaptive clinical trial designs, challenges are present to drug supply chain management which may offset the benefit of adaptive designs. Thus, it is necessary to develop an optimization tool to facilitate the…

应用统计 · 统计学 2023-10-16 Jincheng Pang , Hong Yan , Zoe Hua

Quick and accurate medical diagnosis is crucial for the successful treatment of a disease. Using machine learning algorithms, we have built two models to predict a hematologic disease, based on laboratory blood test results. In one…

Sampling rare events in metastable dynamical systems is often a computationally expensive task and one needs to resort to enhanced sampling methods such as importance sampling. Since we can formulate the problem of finding optimal…

最优化与控制 · 数学 2023-10-05 Enric Ribera Borrell , Jannes Quer , Lorenz Richter , Christof Schütte

We consider the problem of online allocation (matching and assortments) of reusable resources where customers arrive sequentially in an adversarial fashion and allocated resources are used or rented for a stochastic duration that is drawn…

数据结构与算法 · 计算机科学 2022-07-20 Vineet Goyal , Garud Iyengar , Rajan Udwani

In this paper, a simple heuristic is proposed for the design of uncertainty aware predictive controllers for nonlinear models involving uncertain parameters. The method relies on Machine Learning-based approximation of ideal deterministic…

系统与控制 · 电气工程与系统科学 2021-02-05 Mazen Alamir

In many situations, simulation models are developed to handle complex real-world business optimisation problems. For example, a discrete-event simulation model is used to simulate the trailer management process in a big Fast-Moving Consumer…

神经与进化计算 · 计算机科学 2019-07-18 Dylan Rijnen , Jason Rhuggenaath , Paulo R. de O. da Costa , Yingqian Zhang

The problem of fast items retrieval from a fixed collection is often encountered in most computer science areas, from operating system components to databases and user interfaces. We present an approach based on hash tables that focuses on…

神经与进化计算 · 计算机科学 2020-07-17 Dan Domnita , Ciprian Oprisa

We introduce a novel approach based on stochastic optimization to find the optimal sampling distribution for the data-driven stability analysis of switched linear systems. Our goal is to address limitations of existing approaches, in…

最优化与控制 · 数学 2025-09-01 Alexis Vuille , Guillaume O. Berger , Raphaël M. Jungers

Motivated by a wide variety of applications, this paper introduces a general class of networks of stochastic loss systems in which congestion renders lost revenue due to customers or jobs being permanently removed from the system. We seek…

网络与互联网体系结构 · 计算机科学 2022-05-12 Brendan Patch , Mark S. Squillante , Peter M. Van de Ven

In this paper, we present a novel nonlinear programming-based approach to fine-tune pre-trained neural networks to improve robustness against adversarial attacks while maintaining high accuracy on clean data. Our method introduces…

机器学习 · 计算机科学 2024-10-28 Shudian Zhao , Jan Kronqvist

Cluster analysis plays an important role in decision making process for many knowledge-based systems. There exist a wide variety of different approaches for clustering applications including the heuristic techniques, probabilistic models,…

人工智能 · 计算机科学 2017-03-09 Kayvan Bijari , Hadi Zare , Hadi Veisi , Hossein Bobarshad

Acting to complete tasks in stochastic partially observable domains is an important problem in artificial intelligence, and is often formulated as a goal-based POMDP. Goal-based POMDPs can be solved using the RTDP-BEL algorithm, that…

人工智能 · 计算机科学 2024-10-10 Guy Shani

We propose a sampling-based trajectory optimization methodology for constrained problems. We extend recent works on stochastic search to deal with box control constraints,as well as nonlinear state constraints for discrete dynamical…

最优化与控制 · 数学 2019-11-13 George I. Boutselis , Ziyi Wang , Evangelos A. Theodorou

This paper proposes an analytical framework for modelling resource contention in multi-robot systems, where the travel times and task durations are uncertain. It uses several approximation methods to quickly and accurately calculate the…

多智能体系统 · 计算机科学 2020-03-17 Andrew W. Palmer , Andrew J. Hill , Steven J. Scheding

Deterministic databases enable scalable replicated systems by executing transactions in a predetermined order. However, existing designs fail to capture transaction dependencies, leading to insufficient scheduling, high abort rates, and…

数据库 · 计算机科学 2025-09-03 Junfang Huang , Yu Yan , Hongzhi Wang , Yingze Li , Jinghan Lin

Reachability analysis is an important method in providing safety guarantees for systems with unknown or uncertain dynamics. Due to the computational intractability of exact reachability analysis for general nonlinear, high-dimensional…

系统与控制 · 电气工程与系统科学 2025-09-12 Elizabeth Dietrich , Rosalyn Devonport , Stephen Tu , Murat Arcak

We aim to create the highest possible quality of treatment-control matches for categorical data in the potential outcomes framework. Matching methods are heavily used in the social sciences due to their interpretability, but most matching…

机器学习 · 统计学 2019-06-11 Yameng Liu , Aw Dieng , Sudeepa Roy , Cynthia Rudin , Alexander Volfovsky

We study a multi-objective model on the allocation of reusable resources under model uncertainty. Heterogeneous customers arrive sequentially according to a latent stochastic process, request for certain amounts of resources, and occupy…

最优化与控制 · 数学 2023-08-02 Xilin Zhang , Wang Chi Cheung

In this work, we develop a game-theoretic modeling of the interaction between a human operator and an autonomous decision aid when they collaborate in a multi-agent task allocation setting. In this setting, we propose a decision aid that is…

多智能体系统 · 计算机科学 2021-12-21 Larkin Heintzman , Ryan K. Williams