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Proton pencil beam scanning (PBS) treatment planning for head and neck (H&N) cancers is a time-consuming and experience-demanding task where a large number of planning objectives are involved. Deep reinforcement learning (DRL) has recently…

定量方法 · 定量生物学 2024-09-19 Qingqing Wang , Chang Chang

Head-and-neck cancer (HNC) planning is difficult because multiple critical organs-at-risk (OARs) are close to complex targets. Intensity-modulated carbon-ion therapy (IMCT) offers superior dose conformity and OAR sparing but remains slow…

Background: Real-time treatment planning in IMRT is challenging due to complex beam interactions. AI has improved automation, but existing models require large, high-quality datasets and lack universal applicability. Deep reinforcement…

医学物理 · 物理学 2025-02-26 Md Mainul Abrar , Parvat Sapkota , Damon Sprouts , Xun Jia , Yujie Chi

This paper presents the first deep reinforcement learning (DRL) framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimensional action and state…

人工智能 · 计算机科学 2018-01-30 Ning Liu , Ying Liu , Brent Logan , Zhiyuan Xu , Jian Tang , Yanzhi Wang

High-dose-rate (HDR) brachytherapy plays a critical role in the treatment of locally advanced cervical cancer but remains highly dependent on manual treatment planning expertise. The objective of this study is to develop a fully automated…

Purpose: In high-dose-rate (HDR) prostate brachytherapy procedures, the pattern of needle placement solely relies on physician experience. We investigated the feasibility of using reinforcement learning (RL) to provide needle positions and…

医学物理 · 物理学 2025-06-12 Tonghe Wang , Yining Feng , Xiaofeng Yang

Objective: Intensity-modulated radiation therapy (IMRT) beam angle optimization (BAO) is a challenging combinatorial optimization problem that is NP-hard. In this study, we aim to develop a personalized BAO algorithm for IMRT that improves…

医学物理 · 物理学 2023-03-08 Peng Bao , Gong Wang , Ruijie Yang , Bin Dong

The development of a digital twin (DT) framework for fast online adaptive proton therapy planning in prostate stereotactic body radiation therapy (SBRT) with dominant intraprostatic lesion (DIL) boost represents a significant advancement in…

Inverse treatment planning in radiation therapy is formulated as optimization problems. The objective function and constraints consist of multiple terms designed for different clinical and practical considerations. Weighting factors of…

We previously proposed an intelligent automatic treatment planning framework for radiotherapy, in which a virtual treatment planner network (VTPN) was built using deep reinforcement learning (DRL) to operate a treatment planning system…

医学物理 · 物理学 2021-06-09 Chenyang Shen , Liyuan Chen , Yesenia Gonzalez , Xun Jia

Deep reinforcement learning (DRL) has become a powerful tool for complex decision-making in machine learning and AI. However, traditional methods often assume perfect action execution, overlooking the uncertainties and deviations between an…

机器人学 · 计算机科学 2025-07-02 Oren Fivel , Matan Rudman , Kobi Cohen

Head and neck cancer (HNC) patients who undergo radiotherapy (RT) may experience anatomical changes during treatment, compromising the validity of the initial treatment plan, necessitating replanning. However, replanning disrupts clinical…

Effective patient monitoring is vital for timely interventions and improved healthcare outcomes. Traditional monitoring systems often struggle to handle complex, dynamic environments with fluctuating vital signs, leading to delays in…

机器学习 · 计算机科学 2024-10-30 Thanveer Shaik , Xiaohui Tao , Lin Li , Haoran Xie , Hong-Ning Dai , Feng Zhao , Jianming Yong

Purpose: Several inverse planning algorithms have been developed for Gamma Knife (GK) radiosurgery to determine a large number of plan parameters via solving an optimization problem, which typically consists of multiple objectives. The…

Conventional data augmentation realized by performing simple pre-processing operations (\eg, rotation, crop, \etc) has been validated for its advantage in enhancing the performance for medical image segmentation. However, the data generated…

图像与视频处理 · 电气工程与系统科学 2020-02-25 Tiexin Qin , Ziyuan Wang , Kelei He , Yinghuan Shi , Yang Gao , Dinggang Shen

We propose a fast beam orientation selection method, based on deep neural networks (DNN), capable of developing a plan comparable to those by the state-of-the-art column generation method. The novelty of Our model lies in its supervised…

医学物理 · 物理学 2019-12-23 Azar Sadeghnejad Barkousaraie , Olalekan Ogunmolu , Steve Jiang , Dan Nguyen

Radiotherapy (RT) is a critical cancer treatment, with volumetric modulated arc therapy (VMAT) being a commonly used technique that enhances dose conformity by dynamically adjusting multileaf collimator (MLC) positions and monitor units…

医学物理 · 物理学 2025-06-26 Stefanos Achlatis , Efstratios Gavves , Jan-Jakob Sonke

Purpose: To demonstrate the feasibility of fast Monte Carlo (MC) based inverse biological planning for the treatment of head and neck tumors in spot-scanning proton therapy. Methods: Recently, a fast and accurate Graphics Processor Unit…

医学物理 · 物理学 2016-10-11 H. Wan Chan Tseung , J. Ma , C. R. Kreofsky , D. Ma , C. Beltran

Deep learning-based automated contouring and treatment planning has been proven to improve the efficiency and accuracy of radiotherapy. However, conventional radiotherapy treatment planning process has the automated contouring and treatment…

医学物理 · 物理学 2024-12-02 Sangwook Kim , Aly Khalifa , Thomas G. Purdie , Chris McIntosh

Reinforcement learning algorithms are gaining popularity in fields in which optimal scheduling is important, and oncology is not an exception. The complex and uncertain dynamics of cancer limit the performance of traditional model-based…

机器学习 · 计算机科学 2019-09-04 Jesus Tordesillas , Juncal Arbelaiz
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