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Recent breakthroughs in cancer research have come via the up-and-coming field of pathway analysis. By applying statistical methods to prior known gene and protein regulatory information, pathway analysis provides a meaningful way to…

基因组学 · 定量生物学 2017-10-11 Yue Zhao

Multi-agent reinforcement learning (MARL) methods have achieved state-of-the-art results on a range of multi-agent tasks. Yet, MARL algorithms typically require significantly more environment interactions than their single-agent…

系统与控制 · 电气工程与系统科学 2026-03-17 Tom Danino , Nahum Shimkin

Multi-agent reinforcement learning (MARL) has been applied and shown great potential in multi-intersections traffic signal control, where multiple agents, one for each intersection, must cooperate together to optimize traffic flow. To…

多智能体系统 · 计算机科学 2022-05-30 Jinming Ma , Feng Wu

Multi-Agent Reinforcement Learning (MARL) has become a powerful framework for numerous real-world applications, modeling distributed decision-making and learning from interactions with complex environments. Resource Allocation Optimization…

多智能体系统 · 计算机科学 2025-05-01 Mohamad A. Hady , Siyi Hu , Mahardhika Pratama , Jimmy Cao , Ryszard Kowalczyk

Feature generation (FG) aims to enhance the prediction potential of original data by constructing high-order feature combinations and removing redundant features. It is a key preprocessing step for tabular scientific data to improve…

机器学习 · 计算机科学 2025-07-10 Meng Xiao , Junfeng Zhou , Yuanchun Zhou

Biological pathways map gene-gene interactions that govern all human processes. Despite their importance, most ML models treat genes as unstructured tokens, discarding known pathway structure. The latest pathway-informed models capture…

机器学习 · 计算机科学 2025-09-03 Gavin Wong , Ping Shu Ho , Ivan Au Yeung , Ka Chun Cheung , Simon See

We propose a novel model named Multi-Channel Attention Selection Generative Adversarial Network (SelectionGAN) for guided image-to-image translation, where we translate an input image into another while respecting an external semantic…

计算机视觉与模式识别 · 计算机科学 2022-10-07 Hao Tang , Philip H. S. Torr , Nicu Sebe

Recent advancements in generative models have established state-of-the-art benchmarks in the generation of molecules and novel drug candidates. Despite these successes, a significant gap persists between generative models and the…

机器学习 · 计算机科学 2024-10-10 Aditya Malusare , Vaneet Aggarwal

In recent years, Model-based Multi-Agent Reinforcement Learning (MARL) has demonstrated significant advantages over model-free methods in terms of sample efficiency by using independent environment dynamics world models for data sample…

多智能体系统 · 计算机科学 2025-01-20 Zifeng Shi , Meiqin Liu , Senlin Zhang , Ronghao Zheng , Shanling Dong , Ping Wei

Retrieval-Augmented Generation (RAG) enables large language models (LLMs) to access external knowledge sources, but the effectiveness of RAG relies on the coordination between the retriever and the generator. Since these components are…

计算与语言 · 计算机科学 2025-09-24 Junlin Wang , Zehao Wu , Shaowei Lu , Yanlan Li , Xinghao Huang

Preventing collisions in multi-robot navigation is crucial for deployment. This requirement hinders the use of learning-based approaches, such as multi-agent reinforcement learning (MARL), on their own due to their lack of safety…

We introduce a novel large language model (LLM)-driven agent framework, which iteratively refines queries and filters contextual evidence by leveraging dynamically evolving knowledge. A defining feature of the system is its decoupling of…

人工智能 · 计算机科学 2025-04-02 Seyoung Song

Multi-agent reinforcement learning (MARL) has emerged as a useful approach to solving decentralised decision-making problems at scale. Research in the field has been growing steadily with many breakthrough algorithms proposed in recent…

机器学习 · 计算机科学 2022-09-22 Rihab Gorsane , Omayma Mahjoub , Ruan de Kock , Roland Dubb , Siddarth Singh , Arnu Pretorius

Cells regulate themselves via dizzyingly complex biochemical processes called signaling pathways. These are usually depicted as a network, where nodes represent proteins and edges indicate their influence on each other. In order to…

分子网络 · 定量生物学 2021-01-13 David Merrell , Anthony Gitter

Genetic pathways usually encode molecular mechanisms that can inform targeted interventions. It is often challenging for existing machine learning approaches to jointly model genetic pathways (higher-order features) and variants (atomic…

定量方法 · 定量生物学 2021-11-19 Yuan Luo , Chengsheng Mao

Identifying the genes and mutations that drive the emergence of tumors is a major step to improve understanding of cancer and identify new directions for disease diagnosis and treatment. Despite the large volume of genomics data, the…

机器学习 · 计算机科学 2022-04-05 Renan Andrades , Mariana Recamonde-Mendoza

Human immunodeficiency virus (HIV) is a major public health concern in the United States (U.S.), with about 1.2 million people living with it and about 35,000 newly infected each year. There are considerable geographical disparities in HIV…

人工智能 · 计算机科学 2026-04-07 Dinesh Sharma , Ankit Shah , Chaitra Gopalappa

Sample efficiency remains a key challenge in multi-agent reinforcement learning (MARL). A promising approach is to learn a meaningful latent representation space through auxiliary learning objectives alongside the MARL objective to aid in…

多智能体系统 · 计算机科学 2024-06-06 Dom Huh , Prasant Mohapatra

Discovering successful coordinated behaviors is a central challenge in Multi-Agent Reinforcement Learning (MARL) since it requires exploring a joint action space that grows exponentially with the number of agents. In this paper, we propose…

机器学习 · 计算机科学 2021-10-14 Ammar Fayad , Majd Ibrahim

The choice of parameters, and the design of the network architecture are important factors affecting the performance of deep neural networks. Genetic Algorithms (GA) have been used before to determine parameters of a network. Yet, GAs…

计算机视觉与模式识别 · 计算机科学 2018-09-28 Yantao Lu , Burak Kakillioglu , Senem Velipasalar