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Meta-analysis is commonly used to combine results from multiple clinical trials, but traditional meta-analysis methods do not refer explicitly to a population of individuals to whom the results apply and it is not clear how to use their…

Meta-analysis is a systematic approach for understanding a phenomenon by analyzing the results of many previously published experimental studies. It is central to deriving conclusions about the summary effect of treatments and interventions…

计算机与社会 · 计算机科学 2021-04-13 Lu Cheng , Dmitriy A. Katz-Rogozhnikov , Kush R. Varshney , Ioana Baldini

Recent work has made important contributions in the development of causally-interpretable meta-analysis. These methods transport treatment effects estimated in a collection of randomized trials to a target population of interest. Ideally,…

统计方法学 · 统计学 2023-02-08 Justin M. Clark , Kollin W. Rott , James S. Hodges , Jared D. Huling

[See paper for full abstract] Meta-analysis is a crucial tool for answering scientific questions. It is usually conducted on a relatively small amount of ``trusted'' data -- ideally from randomized, controlled trials -- which allow causal…

机器学习 · 统计学 2024-07-15 Shiva Kaul , Geoffrey J. Gordon

While standard meta-analysis pools the results from randomized trials that compare two treatments, network meta-analysis aggregates the results of randomized trials comparing a wider variety of treatment options. However, it is unclear…

统计方法学 · 统计学 2016-08-15 Mireille E. Schnitzer , Russell J. Steele , Michèle Bally , Ian Shrier

Evidence syntheses and meta-analyses are used to inform clinical practice guidelines and health economic evaluations. However, heterogeneity of treatment effects poses a significant challenge. Conventional meta-analysis addresses…

Meta-analyses are regarded as the highest level in the hierarchy of evidence, yet standard models traditionally concentrated on estimating the mean effect size, often under restrictive assumptions about the underlying distribution, such as…

其他统计学 · 统计学 2026-04-02 Yefeng Yang , Shinichi Nakagawa

In causal inference, it is common to estimate the causal effect of a single treatment variable on an outcome. However, practitioners may also be interested in the effect of simultaneous interventions on multiple covariates of a fixed target…

统计方法学 · 统计学 2022-11-24 Jaime Roquero Gimenez , Dominik Rothenhäusler

Meta-analysis can be a critical part of the research process, often serving as the primary analysis on which the practitioners, policymakers, and individuals base their decisions. However, current literature synthesis approaches to…

统计方法学 · 统计学 2023-08-28 Lily H. Zhang , Menelaos Konstantinidis , Marie-Abèle Bind , Donald B. Rubin

Over the past few decades, statistical methods for causal inference have made impressive strides, enabling progress across a range of scientific fields. However, much of this methodological development has been confined to individual…

统计方法学 · 统计学 2025-09-30 Wenqi Shi , José R. Zubizarreta

Causal inference is central to many areas of artificial intelligence, including complex reasoning, planning, knowledge-base construction, robotics, explanation, and fairness. An active community of researchers develops and enhances…

人工智能 · 计算机科学 2019-11-05 Amanda Gentzel , Dan Garant , David Jensen

We present methods for causally interpretable meta-analyses that combine information from multiple randomized trials to estimate potential (counterfactual) outcome means and average treatment effects in a target population. We consider…

Random-effects meta-analyses have been widely applied in evidence synthesis for various types of medical studies. However, standard inference methods (e.g. restricted maximum likelihood estimation) usually underestimate statistical errors…

统计方法学 · 统计学 2019-05-13 Shonosuke Sugasawa , Hisashi Noma

Empirical claims often rely on one population, design, and analysis. Many-analysts, multiverse, and robustness studies expose how results can vary across plausible analytic choices. Synthesizing these results, however, is nontrivial as all…

统计方法学 · 统计学 2025-11-24 František Bartoš , Suzanne Hoogeveen , Alexandra Sarafoglou , Samuel Pawel

Meta-analysis employs statistical techniques to synthesize the results of individual studies, providing an estimate of the overall effect size for a specific outcome of interest. The direction and magnitude of this estimate, along with its…

计量经济学 · 经济学 2025-03-06 Amin Haghnejad , Mahboobeh Farahati

Multivariate meta-analysis is gaining prominence in evidence synthesis research because it enables simultaneous synthesis of multiple correlated outcome data, and random-effects models have generally been used for addressing between-studies…

统计方法学 · 统计学 2021-07-14 Hisashi Noma , Kengo Nagashima , Toshi A. Furukawa

Causal inference analysis is the estimation of the effects of actions on outcomes. In the context of healthcare data this means estimating the outcome of counter-factual treatments (i.e. including treatments that were not observed) on a…

统计方法学 · 统计学 2018-03-21 Yishai Shimoni , Chen Yanover , Ehud Karavani , Yaara Goldschmnidt

To investigate intervention effects on rare events, meta-analysis techniques are commonly applied in order to assess the accumulated evidence. When it comes to adverse effects in clinical trials, these are often most adequately handled…

统计方法学 · 统计学 2026-04-03 Christian Röver , Qiong Wu , Anja Loos , Tim Friede

Causal inference is a critical research topic across many domains, such as statistics, computer science, education, public policy and economics, for decades. Nowadays, estimating causal effect from observational data has become an appealing…

统计方法学 · 统计学 2020-02-10 Liuyi Yao , Zhixuan Chu , Sheng Li , Yaliang Li , Jing Gao , Aidong Zhang

In the absence of randomized controlled and natural experiments, it is necessary to balance the distributions of (observable) covariates of the treated and control groups in order to obtain an unbiased estimate of a causal effect of…

统计方法学 · 统计学 2022-03-02 Martin Cousineau , Vedat Verter , Susan A. Murphy , Joelle Pineau
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