相关论文: Universal Biological Sequence Reranking for Improv…

The development of powerful natural language models have increased the ability to learn meaningful representations of protein sequences. In addition, advances in high-throughput mutagenesis, directed evolution, and next-generation…

Pretraining large language models (LLMs) on vast and heterogeneous datasets is crucial for achieving state-of-the-art performance across diverse downstream tasks. However, current training paradigms treat all samples equally, overlooking…

Cardiac segmentation is an essential step for the diagnosis of cardiovascular diseases. However, pixel-wise dense labeling is both costly and time-consuming. Scribble, as a form of sparse annotation, is more accessible than full…

We propose a novel low-rank initialization framework for training low-rank deep neural networks -- networks where the weight parameters are re-parameterized by products of two low-rank matrices. The most successful prior existing approach,…

Large language models (LLMs), with advanced linguistic capabilities, have been employed in reranking tasks through a sequence-to-sequence approach. In this paradigm, multiple passages are reranked in a listwise manner and a textual reranked…

The use of deep learning has successfully solved several problems in the field of medical imaging. Deep learning has been applied to the CT denoising problem successfully. However, the use of deep learning requires large amounts of data to…

In analyzing of modern biological data, we are often dealing with ill-posed problems and missing data, mostly due to high dimensionality and multicollinearity of the dataset. In this paper, we have proposed a system based on matrix…

Protein sequence design methods have demonstrated strong performance in sequence generation for de novo protein design. However, as the training objective was sequence recovery, it does not guarantee designability--the likelihood that a…

Various methods have been developed to analyze the association between organisms and their genomic sequences. Among them, sequence alignment is the most frequently used for comparative analysis of biological genomes. However, the…

Proteins perform nearly all cellular functions and constitute most drug targets, making their analysis fundamental to understanding human biology in health and disease. Tandem mass spectrometry (MS$^2$) is the major analytical technique in…

Joint-Embedding Self Supervised Learning (JE-SSL) has seen a rapid development, with the emergence of many method variations but only few principled guidelines that would help practitioners to successfully deploy them. The main reason for…

In this work, we introduce a method to fine-tune a Transformer-based generative model for molecular de novo design. Leveraging the superior sequence learning capacity of Transformers over Recurrent Neural Networks (RNNs), our model can…

Reliable and robust evaluation methods are a necessary first step towards developing machine learning models that are themselves robust and reliable. Unfortunately, current evaluation protocols typically used to assess classifiers fail to…

Compressing DNNs is important for the real-world applications operating on resource-constrained devices. However, we typically observe drastic performance deterioration when changing model size after training is completed. Therefore,…

The recent popularity of deep neural networks (DNNs) has generated a lot of research interest in performing DNN-related computation efficiently. However, the primary focus is usually very narrow and limited to (i) inference -- i.e. how to…

We propose a novel DEA ranking based on a robust optimization viewpoint: the higher ranking for those DMU's that remain efficient even for larger variations of data and vice versa. This ranking can be computed by solving generalized linear…

Data imbalance, in which a plurality of the data samples come from a small proportion of labels, poses a challenge in training deep neural networks. Unlike classification, in regression the labels are continuous, potentially boundless, and…

Breast cancer is a highly heterogeneous disease with diverse molecular profiles. The PAM50 gene signature is widely recognized as a standard for classifying breast cancer into intrinsic subtypes, enabling more personalized treatment…

Many optimizers have been proposed for training deep neural networks, and they often have multiple hyperparameters, which make it tricky to benchmark their performance. In this work, we propose a new benchmarking protocol to evaluate both…

How to develop slim and accurate deep neural networks has become crucial for real- world applications, especially for those employed in embedded systems. Though previous work along this research line has shown some promising results, most…