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Alzheimer's Disease (AD) affects over 55 million people globally, yet the key genetic contributors remain poorly understood. Leveraging recent advancements in genomic foundation models, we present the innovative Reverse-Gene-Finder…

机器学习 · 计算机科学 2025-02-07 Victor OK Li , Yang Han , Jacqueline CK Lam

Alzheimer's disease (AD) is a progressive neurodegenerative disease and recently attracts extensive attention worldwide. Speech technology is considered a promising solution for the early diagnosis of AD and has been enthusiastically…

音频与语音处理 · 电气工程与系统科学 2021-10-05 Ying Qin , Wei Liu , Zhiyuan Peng , Si-Ioi Ng , Jingyu Li , Haibo Hu , Tan Lee

Background: Alzheimer's disease and related dementias (ADRD) are progressive neurodegenerative conditions where early detection is vital for timely intervention and care. Spontaneous speech contains rich acoustic and linguistic markers that…

计算与语言 · 计算机科学 2025-06-16 Jingyu Li , Lingchao Mao , Hairong Wang , Zhendong Wang , Xi Mao , Xuelei Sherry Ni

Reliable detection of the prodromal stages of Alzheimer's disease (AD) remains difficult even today because, unlike other neurocognitive impairments, there is no definitive diagnosis of AD in vivo. In this context, existing research has…

机器学习 · 计算机科学 2021-08-03 Amish Mittal , Sourav Sahoo , Arnhav Datar , Juned Kadiwala , Hrithwik Shalu , Jimson Mathew

Alzheimer's disease (AD) has become one of the most significant health challenges in an aging society. The use of spoken language-based AD detection methods has gained prevalence due to their scalability due to their scalability. Based on…

计算与语言 · 计算机科学 2024-12-02 Junan Li , Yunxiang Li , Yuren Wang , Xixin Wu , Helen Meng

Recent breakthroughs in Automatic Speech Recognition (ASR) have enabled fully automated Alzheimer's Disease (AD) detection using ASR transcripts. Nonetheless, the impact of ASR errors on AD detection remains poorly understood. This paper…

音频与语音处理 · 电气工程与系统科学 2025-05-27 Yin-Long Liu , Rui Feng , Jia-Xin Chen , Yi-Ming Wang , Jia-Hong Yuan , Zhen-Hua Ling

Alzheimer's disease (AD) is a neurodegenerative disease that affects nearly 50 million individuals across the globe and is one of the leading causes of deaths globally. It is projected that by 2050, the number of people affected by the…

机器学习 · 计算机科学 2021-10-26 Yash Kumar , Piyush Maheshwari , Shreyansh Joshi , Veeky Baths

Early detection of Alzheimer's disease from spontaneous speech has emerged as a promising non-invasive screening approach. However, the influence of automatic speech recognition (ASR) quality on downstream clinical language modeling remains…

定量方法 · 定量生物学 2026-05-01 Himadri S Samanta

Alzheimer's disease (AD) is a common form of dementia that severely impacts patient health. As AD impairs the patient's language understanding and expression ability, the speech of AD patients can serve as an indicator of this disease. This…

音频与语音处理 · 电气工程与系统科学 2023-07-07 Hongmin Cai , Xiaoke Huang , Zhengliang Liu , Wenxiong Liao , Haixing Dai , Zihao Wu , Dajiang Zhu , Hui Ren , Quanzheng Li , Tianming Liu , Xiang Li

Alzheimer's Dementia (AD) is an incurable, debilitating, and progressive neurodegenerative condition that affects cognitive function. Early diagnosis is important as therapeutics can delay progression and give those diagnosed vital time.…

机器学习 · 计算机科学 2023-02-28 Thomas Searle , Zina Ibrahim , Richard Dobson

We present our submission to the ICASSP-SPGC-2023 ADReSS-M Challenge Task, which aims to investigate which acoustic features can be generalized and transferred across languages for Alzheimer's Disease (AD) prediction. The challenge consists…

计算与语言 · 计算机科学 2025-01-14 Xuchu Chen , Yu Pu , Jinpeng Li , Wei-Qiang Zhang

Timely and accurate assessment of cognitive impairment remains a major unmet need. Speech biomarkers offer a scalable, non-invasive, cost-effective solution for automated screening. However, the clinical utility of machine learning (ML)…

Early diagnosis of Alzheimer's disease (AD) is crucial in facilitating preventive care to delay further progression. This paper presents the development of a state-of-the-art Conformer based speech recognition system built on the…

音频与语音处理 · 电气工程与系统科学 2022-06-28 Tianzi Wang , Jiajun Deng , Mengzhe Geng , Zi Ye , Shoukang Hu , Yi Wang , Mingyu Cui , Zengrui Jin , Xunying Liu , Helen Meng

Early diagnosis of Alzheimer's disease (AD) is crucial in facilitating preventive care and to delay further progression. Speech based automatic AD screening systems provide a non-intrusive and more scalable alternative to other clinical…

计算与语言 · 计算机科学 2023-04-03 Yi Wang , Jiajun Deng , Tianzi Wang , Bo Zheng , Shoukang Hu , Xunying Liu , Helen Meng

Early diagnosis of Alzheimer's disease (AD) is crucial in facilitating preventive care and delay progression. Speech based automatic AD screening systems provide a non-intrusive and more scalable alternative to other clinical screening…

机器学习 · 计算机科学 2022-08-09 Yi Wang , Tianzi Wang , Zi Ye , Lingwei Meng , Shoukang Hu , Xixin Wu , Xunying Liu , Helen Meng

Alzheimer's disease (AD) is an irreversible brain disease that can dramatically reduce quality of life, most commonly manifesting in older adults and eventually leading to the need for full-time care. Early detection is fundamental to…

计算与语言 · 计算机科学 2019-06-14 Flavio Di Palo , Natalie Parde

Alzheimer's disease (AD) is an irreversible and progressive brain disease that can be stopped or slowed down with medical treatment. Language changes serve as a sign that a patient's cognitive functions have been impacted, potentially…

计算与语言 · 计算机科学 2018-04-19 Sweta Karlekar , Tong Niu , Mohit Bansal

Alzheimer's Disease (AD) is nowadays the most common form of dementia, and its automatic detection can help to identify symptoms at early stages, so that preventive actions can be carried out. Moreover, non-intrusive techniques based on…

计算与语言 · 计算机科学 2020-11-21 Mireia Farrús , Joan Codina-Filbà

Alzheimer's Disease is the most common form of dementia. Automatic detection from speech could help to identify symptoms at early stages, so that preventive actions can be carried out. This research is a contribution to the ADReSSo…

计算与语言 · 计算机科学 2021-11-01 Joan Codina-Filbà , Guillermo Cámbara , Jordi Luque , Mireia Farrús

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, affecting memory, reasoning, communication, and daily functioning. Early diagnosis is particularly important, as timely intervention may…

声音 · 计算机科学 2026-05-26 Loukas Ilias , Dimitris Askounis
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