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Large Language Models (LLMs) are increasingly serving as autonomous agents, and their utilization of external tools via the Model Context Protocol (MCP) is considered a future trend. Current MCP evaluation sets suffer from issues such as…

人工智能 · 计算机科学 2026-01-22 Wenrui Liu , Zixiang Liu , Elsie Dai , Wenhan Yu , Lei Yu , Tong Yang , Jinjun Han , Hong Gao

Drug repurposing is often framed as a candidate identification task, but existing approaches provide limited guidance for distinguishing biologically plausible candidates from historically well-connected ones. Here we introduce DrugKLM, a…

Recent artificial intelligence (AI) systems have reached milestones in "grand challenges" ranging from Go to protein-folding. The capability to retrieve medical knowledge, reason over it, and answer medical questions comparably to…

Process-Level Reward Models (PRMs) are essential for guiding complex reasoning in large language models, yet existing PRM benchmarks cover only general domains such as mathematics, failing to address medical reasoning -- which is uniquely…

计算与语言 · 计算机科学 2026-04-21 Lingyan Wu , Xiang Zheng , Weiqi Zhai , Wei Wang , Xuan Ren , Zifan Zhang , Hu Wei , Bing Zhao

Medical Large Language Models (MLLMs) have demonstrated potential in healthcare applications, yet their propensity for hallucinations -- generating medically implausible or inaccurate information -- presents substantial risks to patient…

计算与语言 · 计算机科学 2025-04-01 Kaiwen Zuo , Yirui Jiang

Large language models (LLMs) perform well on step-by-step reasoning benchmarks such as mathematics and code generation, yet their ability to carry out robust long-horizon planning under realistic constraints remains insufficiently…

人工智能 · 计算机科学 2026-04-21 Petr Anokhin , Roman Khalikov , Stefan Rebrikov , Viktor Volkov , Artyom Sorokin , Vincent Bissonnette

Demand for mental health support through AI chatbots is surging, though current systems present several limitations, like sycophancy or overvalidation, and reinforcement of maladaptive beliefs. A core obstacle to the creation of better…

计算与语言 · 计算机科学 2025-12-08 José Pombal , Maya D'Eon , Nuno M. Guerreiro , Pedro Henrique Martins , António Farinhas , Ricardo Rei

Understanding and reasoning on the large-scale scientific literature is a crucial touchstone for large language model (LLM) based agents. However, existing works are mainly restricted to tool-free tasks within single papers, largely due to…

人工智能 · 计算机科学 2026-02-02 Daoyu Wang , Mingyue Cheng , Shuo Yu , Zirui Liu , Ze Guo , Xin Li , Qi Liu

Web agents such as Deep Research have demonstrated superhuman cognitive abilities, capable of solving highly challenging information-seeking problems. However, most research remains primarily text-centric, overlooking visual information in…

Multimodal Large Language Models (MLLMs) have demonstrated impressive abilities across various tasks, including visual question answering and chart comprehension, yet existing benchmarks for chart-related tasks fall short in capturing the…

计算与语言 · 计算机科学 2025-02-11 Zifeng Zhu , Mengzhao Jia , Zhihan Zhang , Lang Li , Meng Jiang

Incorporating large language models (LLMs) in medical question answering demands more than high average accuracy: a model that returns substantively different answers each time it is queried is not a reliable medical tool. Online health…

信息检索 · 计算机科学 2026-04-14 Avi-ad Avraam Buskila

Objectives: To evaluate the current limitations of large language models (LLMs) in medical question answering, focusing on the quality of datasets used for their evaluation. Materials and Methods: Widely-used benchmark datasets, including…

计算与语言 · 计算机科学 2025-07-15 Mahmoud Alwakeel , Aditya Nagori , Vijay Krishnamoorthy , Rishikesan Kamaleswaran

While Multimodal Large Language Models (MLLMs) show promising performance in automated electrocardiogram interpretation, it remains unclear whether they genuinely perform actual step-by-step reasoning or just rely on superficial visual…

机器学习 · 计算机科学 2026-03-17 Jungwoo Oh , Hyunseung Chung , Junhee Lee , Min-Gyu Kim , Hangyul Yoon , Ki Seong Lee , Youngchae Lee , Muhan Yeo , Edward Choi

In this work, we introduce MedAgentSim, an open-source simulated clinical environment with doctor, patient, and measurement agents designed to evaluate and enhance LLM performance in dynamic diagnostic settings. Unlike prior approaches, our…

计算与语言 · 计算机科学 2025-10-02 Mohammad Almansoori , Komal Kumar , Hisham Cholakkal

Large language models (LLMs) have saturated standard medical benchmarks that test factual recall, yet their ability to perform higher-order reasoning, such as synthesizing evidence from multiple sources, remains critically under-explored.…

计算与语言 · 计算机科学 2026-05-12 Huy Hoang Ha , Benoit Favre , Francois Portet

Large language models (LLMs) are increasingly used in the mental health domain, yet it remains unclear how well they capture related biomedical knowledge and how reliably they apply it to clinically salient structured judgments. Here, we…

Large Language Models (LLMs) have shown strong potential in complex medical reasoning yet face diminishing gains under inference scaling laws. While existing studies augment LLMs with various knowledge types, it remains unclear how…

人工智能 · 计算机科学 2026-02-10 Yu Zhao , Hao Guan , Yongcheng Jing , Ying Zhang , Dacheng Tao

The rise of large language models (LLMs) has transformed healthcare by offering clinical guidance, yet their direct deployment to patients poses safety risks due to limited domain expertise. To mitigate this, we propose repositioning LLMs…

计算与语言 · 计算机科学 2025-10-14 Wenya Xie , Qingying Xiao , Yu Zheng , Xidong Wang , Junying Chen , Ke Ji , Anningzhe Gao , Prayag Tiwari , Xiang Wan , Feng Jiang , Benyou Wang

Medical Multimodal Large Language Models (Med-MLLMs) require egocentric clinical intent understanding for real-world deployment, yet existing benchmarks fail to evaluate this critical capability. To address these challenges, we introduce…

计算机视觉与模式识别 · 计算机科学 2026-01-13 Shaonan Liu , Guo Yu , Xiaoling Luo , Shiyi Zheng , Wenting Chen , Jie Liu , Linlin Shen

With the growing use of language models (LMs) in clinical environments, there is an immediate need to evaluate the accuracy and safety of LM-generated medical text. Currently, such evaluation relies solely on manual physician review.…