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Biomarker discovery from high-throughput transcriptomic data is crucial for advancing precision medicine. However, existing methods often neglect gene-gene regulatory relationships and lack stability across datasets, leading to conflation…

定量方法 · 定量生物学 2025-11-18 Chaowang Lan , Jingxin Wu , Yulong Yuan , Chuxun Liu , Huangyi Kang , Caihua Liu

Evaluating the causal effect of an intervention on multivariate outcomes is challenging when the outcomes are interdependent and derived rather than directly observed. Effective connectivity, which summarizes the directional neural…

统计方法学 · 统计学 2026-04-02 Haiyue Song , Ani Eloyan , Youjin Lee

Parametric system identification methods estimate the parameters of explicitly defined physical systems from data. Yet, they remain constrained by the need to provide an explicit function space, typically through a predefined library of…

机器学习 · 计算机科学 2026-03-17 Markus W. Baumgartner , Anson Lei , Joe Watson , Ingmar Posner

It has become increasingly popular to study the brain as a network due to the realization that functionality cannot be explained exclusively by independent activation of specialized regions. Instead, across a large spectrum of behaviors,…

神经元与认知 · 定量生物学 2014-07-22 Petko Bogdanov , Nazli Dereli , Danielle S. Bassett , Scott T. Grafton , Ambuj K. Singh

The field of hypothesis generation promises to reduce costs in neuroscience by narrowing the range of interventional studies needed to study various phenomena. Existing machine learning methods can generate scientific hypotheses from…

机器学习 · 计算机科学 2025-07-04 Zachary C. Brown , David Carlson

Multivariate dynamical processes can often be intuitively described by a weighted connectivity graph between components representing each individual time-series. Even a simple representation of this graph as a Pearson correlation matrix may…

机器学习 · 计算机科学 2022-02-15 Usman Mahmood , Zening Fu , Vince Calhoun , Sergey Plis

Many analyses of functional magnetic resonance imaging (fMRI) examine functional connectivity (FC), or the statistical dependencies among distant brain regions. These analyses are typically exploratory, guiding future confirmatory research.…

应用统计 · 统计学 2025-10-20 Kyle Stanley , Nicole Lazar , Matthew Reimherr

In recent years, functional magnetic resonance imaging has emerged as a powerful tool for investigating the human brain's functional connectivity networks. Related studies demonstrate that functional connectivity networks in the human brain…

人工智能 · 计算机科学 2023-09-18 Xiangzhu Meng , Wei Wei , Qiang Liu , Shu Wu , Liang Wang

The human brain is a complex, dynamic network, which is commonly studied using functional magnetic resonance imaging (fMRI) and modeled as network of Regions of interest (ROIs) for understanding various brain functions. Recent studies…

定量方法 · 定量生物学 2024-06-26 Yifan Yang , Yutong Mao , Xufu Liu , Xiao Liu

This thesis is dedicated to the statistical analysis of multi-sub ject fMRI data, with the purpose of identifying bain structures involved in certain cognitive or sensori-motor tasks, in a reproducible way across sub jects. To overcome…

应用统计 · 统计学 2010-05-19 Merlin Keller , Alexis Roche , Marc Lavielle

We introduce a method that takes advantage of high-quality pretrained multimodal representations to explore fine-grained semantic networks in the human brain. Previous studies have documented evidence of functional localization in the…

人工智能 · 计算机科学 2023-06-07 Cory Efird , Alex Murphy , Joel Zylberberg , Alona Fyshe

Understanding how the brain encodes external stimuli and how these stimuli can be decoded from the measured brain activities are long-standing and challenging questions in neuroscience. In this paper, we focus on reconstructing the complex…

神经元与认知 · 定量生物学 2022-10-05 Sikun Lin , Thomas Sprague , Ambuj K Singh

Learning task models of bimanual manipulation from human demonstration and their execution on a robot should take temporal constraints between actions into account. This includes constraints on (i) the symbolic level such as precedence…

机器人学 · 计算机科学 2024-10-27 Christian Dreher , Tamim Asfour

Task-based functional magnetic resonance imaging (task fMRI) is a non-invasive technique that allows identifying brain regions whose activity changes when individuals are asked to perform a given task. This contributes to the understanding…

统计方法学 · 统计学 2021-03-17 Yasser Aleman-Gomez , Ana Arribas-Gil , Manuel Desco , Antonio Elias-Fernandez , Juan Romo

Dynamic effective connectivity networks (dECNs) reveal the changing directed brain activity and the dynamic causal influences among brain regions, which facilitate the identification of individual differences and enhance the understanding…

机器学习 · 计算机科学 2025-02-03 Faming Xu , Yiding Wang , Chen Qiao , Gang Qu , Vince D. Calhoun , Julia M. Stephen , Tony W. Wilson , Yu-Ping Wang

A central challenge in the computational modeling of neural dynamics is the trade-off between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are both experimentally established and essential for neuronal…

Functional magnetic resonance imaging (fMRI) is widely used for studying and diagnosing brain disorders, with functional connectivity (FC) matrices providing powerful representations of large-scale neural interactions. However, existing…

组织与器官 · 定量生物学 2026-04-17 Qianyu Chen , Shujian Yu

Estimating causal interactions in the brain from functional magnetic resonance imaging (fMRI) data remains a challenging task. Multiple studies have demonstrated that all current approaches to determine direction of connectivity perform…

神经元与认知 · 定量生物学 2019-05-31 Natalia Bielczyk , Alberto Llera , Jan Buitelaar , Jeffrey Glennon , Christian Beckmann

Causal discovery for dynamical systems poses a major challenge in fields where active interventions are infeasible. Most methods used to investigate these systems and their associated benchmarks are tailored to deterministic,…

机器学习 · 计算机科学 2025-10-13 Benjamin Herdeanu , Juan Nathaniel , Carla Roesch , Jatan Buch , Gregor Ramien , Johannes Haux , Pierre Gentine

Autism spectrum disorder (ASD) is a neurological and developmental disorder that affects social and communicative behaviors. It emerges in early life and is generally associated with lifelong disabilities. Thus, accurate and early diagnosis…

图像与视频处理 · 电气工程与系统科学 2025-02-24 Peiyu Duan , Nicha C. Dvornek , Jiyao Wang , Lawrence H. Staib , James S. Duncan