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Single-cell perturbation prediction aims to infer how cells respond to unseen interventions and to achieve out-of-distribution (OOD) generalization, providing a computational route to understanding how perturbations reshape cellular…

机器学习 · 计算机科学 2026-05-26 Wenkang Jiang , Yuhang Liu , Erdun Gao , Ehsan Abbasnejad , Lina Yao , Javen Qinfeng Shi

Single-cell RNA sequencing (scRNA-seq) provides unprecedented insights into cellular heterogeneity, enabling detailed analysis of complex biological systems at single-cell resolution. However, the high dimensionality and technical noise…

基因组学 · 定量生物学 2025-09-04 Hojjat Torabi Goudarzi , Maziyar Baran Pouyan

Variational Auto-Encoders (VAEs) are capable of learning latent representations for high dimensional data. However, due to the i.i.d. assumption, VAEs only optimize the singleton variational distributions and fail to account for the…

机器学习 · 计算机科学 2020-04-20 Da Tang , Dawen Liang , Tony Jebara , Nicholas Ruozzi

Diversity plays a vital role in many text generating applications. In recent years, Conditional Variational Auto Encoders (CVAE) have shown promising performances for this task. However, they often encounter the so called KL-Vanishing…

机器学习 · 统计学 2019-03-27 Yuchi Zhang , Yongliang Wang , Liping Zhang , Zhiqiang Zhang , Kun Gai

In recent years, applying Deep Learning (DL) techniques emerged as a common practice in the communication system, demonstrating promising results. The present paper proposes a new Convolutional Neural Network (CNN) based Variational…

信号处理 · 电气工程与系统科学 2020-05-20 Raghu Vamshi Hemadri , Akshay Rayaluru , Rahul Jashvantbhai Pandya

Recent state-of-the-art autoencoder based generative models have an encoder-decoder structure and learn a latent representation with a pre-defined distribution that can be sampled from. Implementing the encoder networks of these models in a…

机器学习 · 计算机科学 2020-05-11 D. T. Braithwaite , M. O'Connor , W. B. Kleijn

Single-cell representation learning (SCRL) from gene expression data offers a way to uncover the complex regulatory logic underlying cellular function. Inspired by large language models in natural language modeling, several single-cell…

机器学习 · 计算机科学 2026-05-11 Sachini Weerasekara , Natasha Darras , Sagar Kamarthi , Colles Price , Jacqueline Isaacs

To extract robust deep representations from long sequential modeling of speech data, we propose a self-supervised learning approach, namely Contrastive Separative Coding (CSC). Our key finding is to learn such representations by separating…

音频与语音处理 · 电气工程与系统科学 2021-03-02 Jun Wang , Max W. Y. Lam , Dan Su , Dong Yu

Neural conversation models such as encoder-decoder models are easy to generate bland and generic responses. Some researchers propose to use the conditional variational autoencoder(CVAE) which maximizes the lower bound on the conditional…

计算与语言 · 计算机科学 2019-11-25 Jun Gao , Wei Bi , Xiaojiang Liu , Junhui Li , Guodong Zhou , Shuming Shi

The cosmic microwave background power spectra are a primary window into the early universe. However, achieving interpretable, likelihood-compatible compression and fast inference under weak model assumptions remains challenging. We propose…

宇宙学与河外天体物理 · 物理学 2025-11-03 Tian-Yang Sun , Tian-Nuo Li , He Wang , Jing-Fei Zhang , Xin Zhang

One of the major shortcomings of variational autoencoders is the inability to produce generations from the individual modalities of data originating from mixture distributions. This is primarily due to the use of a simple isotropic Gaussian…

机器学习 · 计算机科学 2019-12-02 Frantzeska Lavda , Magda Gregorová , Alexandros Kalousis

One major challenge of disentanglement learning with variational autoencoders is the trade-off between disentanglement and reconstruction fidelity. Previous studies, which increase the information bottleneck during training, tend to lose…

机器学习 · 计算机科学 2023-10-05 Jiantao Wu , Shentong Mo , Xiang Yang , Muhammad Awais , Sara Atito , Xingshen Zhang , Lin Wang , Xiang Yang

Multimodal sensory data resembles the form of information perceived by humans for learning, and are easy to obtain in large quantities. Compared to unimodal data, synchronization of concepts between modalities in such data provides…

机器学习 · 统计学 2018-05-30 Wei-Ning Hsu , James Glass

Network models provide a powerful framework for analysing single-cell count data, facilitating the characterisation of cellular identities, disease mechanisms, and developmental trajectories. However, uncertainty modeling in unsupervised…

基因组学 · 定量生物学 2026-04-27 Shanshan Ren , Thomas E. Bartlett , Lina Gerontogianni , Swati Chandna

Multi-label classification (MLC) is a prediction task where each sample can have more than one label. We propose a novel contrastive learning boosted multi-label prediction model based on a Gaussian mixture variational autoencoder…

机器学习 · 计算机科学 2022-06-13 Junwen Bai , Shufeng Kong , Carla P. Gomes

Variational autoencoders (VAEs) are widely used deep generative models capable of learning unsupervised latent representations of data. Such representations are often difficult to interpret or control. We consider the problem of…

机器学习 · 计算机科学 2018-12-18 Jack Klys , Jake Snell , Richard Zemel

Motivation: Despite advances in the computational analysis of high-throughput molecular profiling assays (e.g. transcriptomics), a dichotomy exists between methods that are simple and interpretable, and ones that are complex but with lower…

机器学习 · 计算机科学 2023-06-12 Pedro Henrique da Costa Avelar , Min Wu , Sophia Tsoka

Embracing the deep learning techniques for representation learning in clustering research has attracted broad attention in recent years, yielding a newly developed clustering paradigm, viz. the deep clustering (DC). Typically, the DC models…

机器学习 · 计算机科学 2022-01-17 Shuai Chang

Single-cell RNA sequencing enables high-resolution analysis of cellular heterogeneity, yet disentangling biological signal from batch effects remains a major challenge. Existing batch-correction algorithms suppress or discard batch-related…

机器学习 · 计算机科学 2025-11-07 Aixa X. Andrade , Son Nguyen , Austin Marckx , Albert Montillo

Equipping robots with the ability to infer human intent is a vital precondition for effective collaboration. Most computational approaches towards this objective derive a probability distribution of "intent" conditioned on the robot's…

机器人学 · 计算机科学 2022-08-02 Mark Zolotas , Yiannis Demiris