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One component of precision medicine is to construct prediction models with their predictive ability as high as possible, e.g. to enable individual risk prediction. In genetic epidemiology, complex diseases have a polygenic basis and a…

机器学习 · 统计学 2019-01-28 Damian Gola , Inke R. König

Locating lesions is important in the computer-aided diagnosis of X-ray images. However, box-level annotation is time-consuming and laborious. How to locate lesions accurately with few, or even without careful annotations is an urgent…

计算机视觉与模式识别 · 计算机科学 2021-02-02 Gangming Zhao , Baolian Qi , Jinpeng Li

As our population ages, neurological impairments and degeneration of the musculoskeletal system yield gait abnormalities, which can significantly reduce quality of life. Gait rehabilitative therapy has been widely adopted to help patients…

计算机视觉与模式识别 · 计算机科学 2017-02-02 Ioannis Papavasileiou , Wenlong Zhang , Xin Wang , Jinbo Bi , Li Zhang , Song Han

The rapid advancement of medical technology has led to an exponential increase in multi-modal medical data, including imaging, genomics, and electronic health records (EHRs). Graph neural networks (GNNs) have been widely used to represent…

定量方法 · 定量生物学 2024-10-03 Favour Nerrise , Alice Louise Heiman , Ehsan Adeli

Atrial fibrillation (AF) is a major complication following embolic stroke of undetermined source (ESUS), elevating the risk of recurrent stroke and mortality. Early identification is clinically important, yet existing tools face limitations…

机器学习 · 计算机科学 2026-03-18 Yuzhang Xie , Yuhua Wu , Ruiyu Wang , Fadi Nahab , Xiao Hu , Carl Yang

Increased effort during use of the paretic arm and hand can provoke involuntary abnormal synergy patterns and amplify stiffness effects of muscle tone for individuals after stroke, which can add difficulty for user-controlled devices to…

Post-stroke rehabilitation is often necessary for patients to regain proper walking gait. However, the typical therapy process can be exhausting and physically demanding for therapists, potentially reducing therapy intensity, duration, and…

机器人学 · 计算机科学 2026-03-04 Grayson Snyder , Lorenzo Vianello , Levi Hargrove , Matthew L. Elwin , Jose Pons

Functional MRI is a neuroimaging technique that analyzes the functional activity of the brain by measuring blood-oxygen-level-dependent signals throughout the brain. The derived functional features can be used for investigating brain…

神经元与认知 · 定量生物学 2026-02-16 Giorgio Dolci , Silvia Saglia , Lorenza Brusini , Vince D. Calhoun , Ilaria Boscolo Galazzo , Gloria Menegaz

Explainable Artificial Intelligence (XAI) is increasingly rec ognized as essential for deploying machine learning systems in safety critical environments. In Automatic Target Recognition (ATR), where models operate on image, video, radar,…

人工智能 · 计算机科学 2026-05-08 Vanessa Buhrmester , David Muench , Dimitri Bulatov , Michael Arens

Understanding the structures why links are formed is an important and prominent research topic. In this paper, we therefore consider the link prediction problem in face-to-face contact networks, and analyze the predictability of new and…

社会与信息网络 · 计算机科学 2014-07-09 Christoph Scholz , Martin Atzmueller , Gerd Stumme

We propose an adaptive node feature selection approach for graph neural networks (GNNs) that identifies and removes unnecessary features during training. The ability to measure how features contribute to model output is key for interpreting…

机器学习 · 计算机科学 2026-05-04 Ali Azizpour , Madeline Navarro , Santiago Segarra

With advanced AI/ML, there has been growing research on explainable AI (XAI) and studies on how humans interact with AI and XAI for effective human-AI collaborative decision-making. However, we still have a lack of understanding of how AI…

人机交互 · 计算机科学 2024-05-28 Min Hun Lee , Silvana Xin Yi Choo , Shamala D/O Thilarajah

Post-hoc interpretability methods play a critical role in explainable artificial intelligence (XAI), as they pinpoint portions of data that a trained deep learning model deemed important to make a decision. However, different post-hoc…

机器学习 · 计算机科学 2024-07-30 Jiawen Wei , Hugues Turbé , Gianmarco Mengaldo

Resting-state fMRI (rs-fMRI) functional connectivity (FC) analysis provides valuable insights into the relationships between different brain regions and their potential implications for neurological or psychiatric disorders. However,…

图像与视频处理 · 电气工程与系统科学 2023-11-20 Xiatian Zhang , Sisi Zheng , Hubert P. H. Shum , Haozheng Zhang , Nan Song , Mingkang Song , Hongxiao Jia

Resting-state functional MRI (rs-fMRI) in functional neuroimaging techniques have improved in brain disorders, dysfunction studies via mapping the topology of the brain connections, i.e. connectopic mapping. Since, there are the slight…

图像与视频处理 · 电气工程与系统科学 2019-07-18 Jalal Mirakhorli , Hamidreza Amindavar , Mojgan Mirakhorli

An important problem in the field of bioinformatics is to identify interactive effects among profiled variables for outcome prediction. In this paper, a logistic regression model with pairwise interactions among a set of binary covariates…

人工智能 · 计算机科学 2016-12-30 Easton Li Xu , Xiaoning Qian , Tie Liu , Shuguang Cui

The study of multi-type Protein-Protein Interaction (PPI) is fundamental for understanding biological processes from a systematic perspective and revealing disease mechanisms. Existing methods suffer from significant performance degradation…

机器学习 · 计算机科学 2021-06-02 Guofeng Lv , Zhiqiang Hu , Yanguang Bi , Shaoting Zhang

Accurate and interpretable survival analysis remains a core challenge in oncology. With growing multimodal data and the clinical need for transparent models to support validation and trust, this challenge increases in complexity. We propose…

人工智能 · 计算机科学 2025-09-29 Mafalda Malafaia , Peter A. N. Bosman , Coen Rasch , Tanja Alderliesten

To explore the mechanistic relationships between ageing, frailty and mortality, we developed a computational model in which possible health attributes are represented by the nodes of a complex network. Each node can be either damaged (i.e.…

种群与进化 · 定量生物学 2017-06-30 Andrew D. Rutenberg , Arnold B. Mitnitski , Spencer Farrell , Kenneth Rockwood

Artificial Intelligence techniques can be used to classify a patient's physical activities and predict vital signs for remote patient monitoring. Regression analysis based on non-linear models like deep learning models has limited…

人工智能 · 计算机科学 2024-10-28 Thanveer Shaik , Xiaohui Tao , Haoran Xie , Lin Li , Juan D. Velasquez , Niall Higgins