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Domain shift is a significant problem in histopathology. There can be large differences in data characteristics of whole-slide images between medical centers and scanners, making generalization of deep learning to unseen data difficult. To…

计算机视觉与模式识别 · 计算机科学 2019-09-27 Karin Stacke , Gabriel Eilertsen , Jonas Unger , Claes Lundström

Domain shift is a critical problem for pathology AI as pathology data is heavily influenced by center-specific conditions. Current pathology domain adaptation methods focus on image patches rather than WSI, thus failing to capture global…

The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…

计算机视觉与模式识别 · 计算机科学 2024-11-26 Manahil Raza , Saad Bashir , Talha Qaiser , Nasir Rajpoot

Domain shift in the field of histopathological imaging is a common phenomenon due to the intra- and inter-hospital variability of staining and digitization protocols. The implementation of robust models, capable of creating generalized…

计算机视觉与模式识别 · 计算机科学 2024-12-06 Ilán Carretero , Pablo Meseguer , Rocío del Amor , Valery Naranjo

Histopathology images; microscopy images of stained tissue biopsies contain fundamental prognostic information that forms the foundation of pathological analysis and diagnostic medicine. However, diagnostics from histopathology images…

计算机视觉与模式识别 · 计算机科学 2019-10-30 Aïcha BenTaieb , Ghassan Hamarneh

The potential of deep neural networks in skin lesion classification has already been demonstrated to be on-par if not superior to the dermatologists diagnosis. However, the performance of these models usually deteriorates when the test data…

计算机视觉与模式识别 · 计算机科学 2023-10-06 Sireesha Chamarthi , Katharina Fogelberg , Roman C. Maron , Titus J. Brinker , Julia Niebling

Computer-aided systems in histopathology are often challenged by various sources of domain shift that impact the performance of these algorithms considerably. We investigated the potential of using self-supervised pre-training to overcome…

Breast cancer diagnosis demands rapid and precise tools, yet traditional histopathological methods often fall short in intra-operative settings. Deep Ultraviolet (DUV) fluorescence imaging emerges as a transformative approach, offering…

计算机视觉与模式识别 · 计算机科学 2026-04-21 Nagur Shareef Shaik , Teja Krishna Cherukuri , Dong Hye Ye

While Whole Slide Imaging (WSI) scanners remain the gold standard for digitizing pathology samples, their high cost limits accessibility in many healthcare settings. Other low-cost solutions also face critical limitations: automated…

计算机视觉与模式识别 · 计算机科学 2025-10-08 Yousef Yeganeh , Maximilian Frantzen , Michael Lee , Kun-Hsing Yu , Nassir Navab , Azade Farshad

Deep learning methods have emerged as powerful tools for analyzing histopathological images, but current methods are often specialized for specific domains and software environments, and few open-source options exist for deploying models in…

Whole Slide Images (WSIs) in digital pathology are used to diagnose cancer subtypes. The difference in procedures to acquire WSIs at various trial sites gives rise to variability in the histopathology images, thus making consistent…

图像与视频处理 · 电气工程与系统科学 2022-04-07 Milad Sikaroudi , Shahryar Rahnamayan , H. R. Tizhoosh

In histopathology, scanner-induced domain shifts are known to impede the performance of trained neural networks when tested on unseen data. Multi-domain pre-training or dedicated domain-generalization techniques can help to develop…

Automated detection of mitotic figures in histopathology images has seen vast improvements, thanks to modern deep learning-based pipelines. Application of these methods, however, is in practice limited by strong variability of images…

The histopathological analysis of whole-slide images (WSIs) is fundamental to cancer diagnosis but is a time-consuming and expert-driven process. While deep learning methods show promising results, dominant patch-based methods artificially…

图像与视频处理 · 电气工程与系统科学 2025-10-08 Alexander Weers , Alexander H. Berger , Laurin Lux , Peter Schüffler , Daniel Rueckert , Johannes C. Paetzold

The deep neural network is a research hotspot for histopathological image analysis, which can improve the efficiency and accuracy of diagnosis for pathologists or be used for disease screening. The whole slide pathological image can reach…

图像与视频处理 · 电气工程与系统科学 2022-05-09 Tingting Zheng , Weixing chen , Shuqin Li , Hao Quan , Qun Bai , Tianhang Nan , Song Zheng , Xinghua Gao , Yue Zhao , Xiaoyu Cui

Due to the recent advancements in machine vision, digital pathology has gained significant attention. Histopathology images are distinctly rich in visual information. The tissue glass slide images are utilized for disease diagnosis.…

图像与视频处理 · 电气工程与系统科学 2020-11-02 Danial Maleki , Mehdi Afshari , Morteza Babaie , H. R. Tizhoosh

Deep learning has advanced deformable image registration, surpassing traditional optimization-based methods in both accuracy and efficiency. However, learning-based models are widely believed to be sensitive to domain shift, with robustness…

计算机视觉与模式识别 · 计算机科学 2025-12-30 Mingzhen Shao , Sarang Joshi

Recent advancements in deep learning (DL) have significantly advanced medical image analysis. In the field of medical image processing, particularly in histopathology image analysis, the variation in staining protocols and differences in…

图像与视频处理 · 电气工程与系统科学 2024-06-25 Parastoo Sotoudeh Sharifi , M. Omair Ahmad , M. N. S. Swamy

$\bf{Purpose:}$ The goal of this study was (i) to use artificial intelligence to automate the traditionally labor-intensive process of manual segmentation of tumor regions in pathology slides performed by a pathologist and (ii) to validate…

In modern cancer diagnostics, Whole Slide Imaging (WSI) is widely used to digitize tissue specimens for detailed, high-resolution examination; however, other diagnostic approaches, such as liquid biopsy and molecular testing, are also…

计算机视觉与模式识别 · 计算机科学 2025-07-02 Seyed Kahaki , Alexander R. Webber , Ghada Zamzmi , Adarsh Subbaswamy , Rucha Deshpande , Aldo Badano
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