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Leveraging multimodal data, particularly the integration of whole-slide histology images (WSIs) and transcriptomic profiles, holds great promise for improving cancer survival prediction. However, excessive redundancy in multimodal data can…

图像与视频处理 · 电气工程与系统科学 2025-03-07 Hong Liu , Haosen Yang , Federica Eduati , Josien P. W. Pluim , Mitko Veta

Multimodal pathology-genomic analysis is critical for cancer survival prediction. However, existing approaches predominantly integrate formalin-fixed paraffin-embedded (FFPE) slides with genomic data, while neglecting the availability of…

计算机视觉与模式识别 · 计算机科学 2025-06-25 Mingcheng Qu , Guang Yang , Donglin Di , Yue Gao , Tonghua Su , Yang Song , Lei Fan

Survival analysis plays a vital role in making clinical decisions. However, the models currently in use are often difficult to interpret, which reduces their usefulness in clinical settings. Prototype learning presents a potential solution,…

计算机视觉与模式识别 · 计算机科学 2025-10-08 Shuo Jiang , Zhuwen Chen , Liaoman Xu , Yanming Zhu , Changmiao Wang , Jiong Zhang , Feiwei Qin , Yifei Chen , Zhu Zhu

Continual learning is essential for adapting models to new tasks while retaining previously acquired knowledge. While existing approaches predominantly focus on uni-modal data, multi-modal learning offers substantial benefits by utilizing…

机器学习 · 计算机科学 2025-11-11 Evelyn Chee , Wynne Hsu , Mong Li Lee

Multimodal molecular representation learning, which jointly models molecular graphs and their textual descriptions, enhances predictive accuracy and interpretability by enabling more robust and reliable predictions of drug toxicity,…

机器学习 · 计算机科学 2025-10-21 Yingxu Wang , Kunyu Zhang , Jiaxin Huang , Nan Yin , Siwei Liu , Eran Segal

With the rapid advances in high-throughput sequencing technologies, the focus of survival analysis has shifted from examining clinical indicators to incorporating genomic profiles with pathological images. However, existing methods either…

图像与视频处理 · 电气工程与系统科学 2023-09-25 Fengtao Zhou , Hao Chen

Survival prediction of cancers is crucial for clinical practice, as it informs mortality risks and influences treatment plans. However, a static model trained on a single dataset fails to adapt to the dynamically evolving clinical…

机器学习 · 计算机科学 2026-01-21 Dianzhi Yu , Conghao Xiong , Yankai Chen , Wenqian Cui , Xinni Zhang , Yifei Zhang , Hao Chen , Joseph J. Y. Sung , Irwin King

Multimodal learning that integrates histopathology images and genomic data holds great promise for cancer survival prediction. However, existing methods face key limitations: 1) They rely on multimodal mapping and metrics in Euclidean…

计算机视觉与模式识别 · 计算机科学 2025-03-19 Jiaqi Yang , Wenting Chen , Xiaohan Xing , Sean He , Xiaoling Luo , Xinheng Lyu , Linlin Shen , Guoping Qiu

Multimodal pathology-genomic analysis has become increasingly prominent in cancer survival prediction. However, existing studies mainly utilize multi-instance learning to aggregate patch-level features, neglecting the information loss of…

计算机视觉与模式识别 · 计算机科学 2025-05-21 Mingcheng Qu , Guang Yang , Donglin Di , Tonghua Su , Yue Gao , Yang Song , Lei Fan

Integrating the different data modalities of cancer patients can significantly improve the predictive performance of patient survival. However, most existing methods ignore the simultaneous utilization of rich semantic features at different…

计算机视觉与模式识别 · 计算机科学 2024-05-14 Liangrui Pan , Yijun Peng , Yan Li , Yiyi Liang , Liwen Xu , Qingchun Liang , Shaoliang Peng

The integration of multimodal data including pathology images and gene profiles is widely applied in precise survival prediction. Despite recent advances in multimodal survival models, collecting complete modalities for multimodal fusion…

机器学习 · 计算机科学 2025-03-25 Yingxue Xu , Fengtao Zhou , Chenyu Zhao , Yihui Wang , Can Yang , Hao Chen

Survival outcome assessment is challenging and inherently associated with multiple clinical factors (e.g., imaging and genomics biomarkers) in cancer. Enabling multimodal analytics promises to reveal novel predictive patterns of patient…

计算机视觉与模式识别 · 计算机科学 2023-07-25 Kexin Ding , Mu Zhou , Dimitris N. Metaxas , Shaoting Zhang

Accurate survival prediction in Non-Small Cell Lung Cancer (NSCLC) requires integrating clinical, radiological, and histopathological data. Multimodal Deep Learning (MDL) can improve precision prognosis, but small cohorts and missing…

Accurate survival prediction in oncology requires integrating diverse imaging modalities to capture the complex interplay of tumor biology. Traditional single-modality approaches often fail to leverage the complementary insights provided by…

计算机视觉与模式识别 · 计算机科学 2025-03-14 Ho Hin Lee , Alberto Santamaria-Pang , Jameson Merkov , Matthew Lungren , Ivan Tarapov

Multimodal models integrating natural language and visual information have substantially improved generalization of representation models. However, their effectiveness significantly declines in real-world situations where certain modalities…

计算机视觉与模式识别 · 计算机科学 2025-11-17 Jiajun Chen , Sai Cheng , Yutao Yuan , Yirui Zhang , Haitao Yuan , Peng Peng , Yi Zhong

We introduce ProtoPathway, an interpretable-by-design multimodal framework for cancer survival prediction that unifies whole slide imaging and transcriptomics through encoders producing biologically grounded representations on both sides of…

计算机视觉与模式识别 · 计算机科学 2026-05-21 Amaya Gallagher-Syed , Costantino Pitzalis , Myles J. Lewis , Michael R. Barnes , Gregory Slabaugh

Background: This research aims to improve glioblastoma survival prediction by integrating MR images, clinical and molecular-pathologic data in a transformer-based deep learning model, addressing data heterogeneity and performance…

Medical decision-making requires integrating diverse medical information, from imaging to clinical narratives. These medical modalities are often acquired in a many-to-many manner. However, current medical vision-language pretraining models…

计算机视觉与模式识别 · 计算机科学 2025-10-01 Yuan Gao , Sangwook Kim , Jianzhong You , Chris McIntosh

We propose a novel multimodal deep learning framework for patient-level survival prediction, which integrates whole-slide histology features, RNA-seq expression profiles, and clinical variables. Our architecture combines an ABMIL…

定量方法 · 定量生物学 2026-05-15 Hassan Keshvarikhojasteh , Josien P. W. Pluim , Mitko Veta

Multimodal survival analysis aims to combine heterogeneous data sources (e.g., clinical, imaging, text, genomics) to improve the prediction quality of survival outcomes. However, this task is particularly challenging due to high…

机器学习 · 计算机科学 2024-12-03 Ling Huang , Yucheng Xing , Qika Lin , Su Ruan , Mengling Feng
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