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In this paper, we propose Stochastic Knowledge Distillation (SKD) to obtain compact BERT-style language model dubbed SKDBERT. In each iteration, SKD samples a teacher model from a pre-defined teacher ensemble, which consists of multiple…

计算与语言 · 计算机科学 2022-11-30 Zixiang Ding , Guoqing Jiang , Shuai Zhang , Lin Guo , Wei Lin

Predicting how genetic perturbations change cellular state is a core problem for building controllable models of gene regulation. Perturbations targeting the same gene can produce different transcriptional responses depending on their…

基因组学 · 定量生物学 2026-02-12 Boyang Fu , George Dasoulas , Sameer Gabbita , Xiang Lin , Shanghua Gao , Xiaorui Su , Soumya Ghosh , Marinka Zitnik

Single-cell RNA-Sequencing (scRNA-Seq) is a revolutionary technique for discovering and describing cell types in heterogeneous tissues, yet its measurement of expression often suffers from large systematic bias. A major source of this bias…

定量方法 · 定量生物学 2016-05-17 Martin Barron , Jun Li

Knowledge distillation (KD) has enabled remarkable progress in model compression and knowledge transfer. However, KD requires a large volume of original data or their representation statistics that are not usually available in practice.…

机器学习 · 计算机科学 2021-02-11 Pengchao Han , Jihong Park , Shiqiang Wang , Yejun Liu

Large-scale models (LSMs) can be an effective framework for semantic representation and understanding, thereby providing a suitable tool for designing semantic communication (SC) systems. However, their direct deployment is often hindered…

机器学习 · 计算机科学 2025-08-26 Kuiyuan Ding , Caili Guo , Yang Yang , Zhongtian Du , Walid Saad

This work presents RNAdiffusion, a latent diffusion model for generating and optimizing discrete RNA sequences of variable lengths. RNA is a key intermediary between DNA and protein, exhibiting high sequence diversity and complex…

机器学习 · 计算机科学 2024-10-03 Kaixuan Huang , Yukang Yang , Kaidi Fu , Yanyi Chu , Le Cong , Mengdi Wang

RNA-sequencing (RNA-seq) has become an exemplar technology in modern biology and clinical applications over the past decade. It has gained immense popularity in the recent years driven by continuous efforts of the bioinformatics community…

Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to analyze gene expression at the cellular level. By providing data on gene expression for each individual cell, scRNA-seq generates large datasets with thousands of…

计算复杂性 · 计算机科学 2025-02-11 Md Romizul Islam , Swakkhar Shatabda

We propose a probabilistic model for interpreting gene expression levels that are observed through single-cell RNA sequencing. In the model, each cell has a low-dimensional latent representation. Additional latent variables account for…

机器学习 · 计算机科学 2017-10-18 Romain Lopez , Jeffrey Regier , Michael Cole , Michael Jordan , Nir Yosef

Recently, a series of diffusion-aware distillation algorithms have emerged to alleviate the computational overhead associated with the multi-step inference process of Diffusion Models (DMs). Current distillation techniques often dichotomize…

计算机视觉与模式识别 · 计算机科学 2024-11-05 Yuxi Ren , Xin Xia , Yanzuo Lu , Jiacheng Zhang , Jie Wu , Pan Xie , Xing Wang , Xuefeng Xiao

Single-cell RNA sequencing (scRNA-seq) has transformed our ability to explore biological systems. Nevertheless, proficient expertise is essential for handling and interpreting the data. In this paper, we present scX, an R package built on…

Knowledge distillation has made remarkable achievements in model compression. However, most existing methods require the original training data, which is usually unavailable due to privacy and security issues. In this paper, we propose a…

计算机视觉与模式识别 · 计算机科学 2022-08-15 Xinyi Yu , Ling Yan , Yang Yang , Libo Zhou , Linlin Ou

Efficiently training accurate deep models for weakly supervised semantic segmentation (WSSS) with image-level labels is challenging and important. Recently, end-to-end WSSS methods have become the focus of research due to their high…

计算机视觉与模式识别 · 计算机科学 2023-02-28 Rongtao Xu , Changwei Wang , Jiaxi Sun , Shibiao Xu , Weiliang Meng , Xiaopeng Zhang

Human placenta is a complex and heterogeneous organ interfacing between the mother and the fetus that supports fetal development. Alterations to placental structural components are associated with various pregnancy complications. To reveal…

组织与器官 · 定量生物学 2020-08-11 Hui Li , Qianhui Huang , Yu Liu , Lana X Garmire

In this paper, we introduce DistDD, a novel approach within the federated learning framework that reduces the need for repetitive communication by distilling data directly on clients' devices. Unlike traditional federated learning that…

机器学习 · 计算机科学 2024-10-14 Peiran Wang , Haohan Wang

While recent diffusion-based generative image codecs have shown impressive performance, their iterative sampling process introduces unpleasing latency. In this work, we revisit the design of a diffusion-based codec and argue that multi-step…

计算机视觉与模式识别 · 计算机科学 2025-11-27 Naifu Xue , Zhaoyang Jia , Jiahao Li , Bin Li , Yuan Zhang , Yan Lu

Dataset distillation has become a popular method for compressing large datasets into smaller, more efficient representations while preserving critical information for model training. Data features are broadly categorized into two types:…

计算机视觉与模式识别 · 计算机科学 2025-03-25 Minh-Tuan Tran , Trung Le , Xuan-May Le , Thanh-Toan Do , Dinh Phung

The rapid development of spatial transcriptomics (ST) technologies is revolutionizing our understanding of the spatial organization of biological tissues. Current ST methods, categorized into next-generation sequencing-based (seq-based) and…

机器学习 · 计算机科学 2024-07-19 Xiaoyu Li , Fangfang Zhu , Wenwen Min

Training on large-scale graphs has achieved remarkable results in graph representation learning, but its cost and storage have attracted increasing concerns. Existing graph condensation methods primarily focus on optimizing the feature…

机器学习 · 计算机科学 2023-10-16 Beining Yang , Kai Wang , Qingyun Sun , Cheng Ji , Xingcheng Fu , Hao Tang , Yang You , Jianxin Li

Knowledge distillation plays a key role in compressing the Large Language Models (LLMs), which boosts a small-size student model under large teacher models' guidance. However, existing LLM distillation methods overly rely on…

计算与语言 · 计算机科学 2024-07-16 Xiaoyu Liu , Yun Zhang , Wei Li , Simiao Li , Xudong Huang , Hanting Chen , Yehui Tang , Jie Hu , Zhiwei Xiong , Yunhe Wang