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Foundation models have emerged as a powerful paradigm in computational pathology (CPath), enabling scalable and generalizable analysis of histopathological images. While early developments centered on uni-modal models trained solely on…

计算机视觉与模式识别 · 计算机科学 2025-03-21 Dong Li , Guihong Wan , Xintao Wu , Xinyu Wu , Xiaohui Chen , Yi He , Christine G. Lian , Peter K. Sorger , Yevgeniy R. Semenov , Chen Zhao

Computational pathology demands both visual pattern recognition and dynamic integration of structured domain knowledge, including taxonomy, grading criteria, and clinical evidence. In practice, diagnostic reasoning requires linking…

As advances in large language models (LLMs) and multimodal techniques continue to mature, the development of general-purpose multimodal large language models (MLLMs) has surged, offering significant applications in interpreting natural…

计算机视觉与模式识别 · 计算机科学 2024-02-20 Yuxuan Sun , Chenglu Zhu , Sunyi Zheng , Kai Zhang , Lin Sun , Zhongyi Shui , Yunlong Zhang , Honglin Li , Lin Yang

Fully supervised segmentation methods require a large training cohort of already segmented images, providing information at the pixel level of each image. We present a method to automatically segment and model pathologies in medical images,…

计算机视觉与模式识别 · 计算机科学 2019-08-22 Simon Andermatt , Antal Horváth , Simon Pezold , Philippe Cattin

As natural image understanding moves towards the pretrain-finetune era, research in pathology imaging is concurrently evolving. Despite the predominant focus on pretraining pathological foundation models, how to adapt foundation models to…

计算机视觉与模式识别 · 计算机科学 2024-07-16 Jiaxuan Lu , Fang Yan , Xiaofan Zhang , Yue Gao , Shaoting Zhang

Large language models (LLMs) excel on general tasks yet still hallucinate in high-barrier domains such as pathology. Prior work often relies on domain fine-tuning, which neither expands the knowledge boundary nor enforces evidence-grounded…

计算与语言 · 计算机科学 2025-10-13 Deshui Yu , Yizhi Wang , Saihui Jin , Taojie Zhu , Fanyi Zeng , Wen Qian , Zirui Huang , Jingli Ouyang , Jiameng Li , Zhen Song , Tian Guan , Yonghong He

Is it possible to develop an "AI Pathologist" to pass the board-certified examination of the American Board of Pathology? To achieve this goal, the first step is to create a visual question answering (VQA) dataset where the AI agent is…

计算与语言 · 计算机科学 2020-03-24 Xuehai He , Yichen Zhang , Luntian Mou , Eric Xing , Pengtao Xie

Vision-language foundation models have shown great promise in computational pathology but remain primarily data-driven, lacking explicit integration of medical knowledge. We introduce KEEP (KnowledgE-Enhanced Pathology), a foundation model…

图像与视频处理 · 电气工程与系统科学 2026-01-28 Xiao Zhou , Luoyi Sun , Dexuan He , Wenbin Guan , Ge Wang , Ruifen Wang , Lifeng Wang , Xiaojun Yuan , Xin Sun , Ya Zhang , Kun Sun , Yanfeng Wang , Weidi Xie

From self-supervised, vision-only models to contrastive visual-language frameworks, computational pathology has rapidly evolved in recent years. Generative AI "co-pilots" now demonstrate the ability to mine subtle, sub-visual tissue cues…

计算机视觉与模式识别 · 计算机科学 2025-02-13 Mohsin Bilal , Aadam , Manahil Raza , Youssef Altherwy , Anas Alsuhaibani , Abdulrahman Abduljabbar , Fahdah Almarshad , Paul Golding , Nasir Rajpoot

Recent pathological foundation models have substantially advanced visual representation learning and multimodal interaction. However, most models still rely on a static inference paradigm in which whole-slide images are processed once to…

计算机视觉与模式识别 · 计算机科学 2025-12-30 Shengyi Hua , Jianfeng Wu , Tianle Shen , Kangzhe Hu , Zhongzhen Huang , Shujuan Ni , Zhihong Zhang , Yuan Li , Zhe Wang , Xiaofan Zhang

Rare cancers comprise 20-25% of all malignancies but face major diagnostic challenges due to limited expert availability-especially in pediatric oncology, where they represent over 70% of cases. While pathology vision-language (VL)…

计算机视觉与模式识别 · 计算机科学 2025-08-25 Dexuan He , Xiao Zhou , Wenbin Guan , Liyuan Zhang , Xiaoman Zhang , Sinuo Xu , Ge Wang , Lifeng Wang , Xiaojun Yuan , Xin Sun , Yanfeng Wang , Kun Sun , Ya Zhang , Weidi Xie

Vision-Language Models (VLMs) are advancing computational pathology with superior visual understanding capabilities. However, current systems often reduce diagnosis to directly output conclusions without verifiable evidence-linked…

计算机视觉与模式识别 · 计算机科学 2026-01-30 Songhan Jiang , Fengchun Liu , Ziyue Wang , Linghan Cai , Yongbing Zhang

Is it possible to develop an "AI Pathologist" to pass the board-certified examination of the American Board of Pathology (ABP)? To build such a system, three challenges need to be addressed. First, we need to create a visual question…

计算机视觉与模式识别 · 计算机科学 2020-10-26 Xuehai He , Zhuo Cai , Wenlan Wei , Yichen Zhang , Luntian Mou , Eric Xing , Pengtao Xie

Artificial intelligence has started to transform histopathology impacting clinical diagnostics and biomedical research. However, while many computational pathology approaches have been proposed, most current AI models are limited with…

In Computational Pathology (CPath), the introduction of Vision-Language Models (VLMs) has opened new avenues for research, focusing primarily on aligning image-text pairs at a single magnification level. However, this approach might not be…

Convolution-based and Transformer-based vision backbone networks process images into the grid or sequence structures, respectively, which are inflexible for capturing irregular objects. Though Vision GNN (ViG) adopts graph-level features…

计算机视觉与模式识别 · 计算机科学 2024-12-11 Jiafu Wu , Jian Li , Jiangning Zhang , Boshen Zhang , Mingmin Chi , Yabiao Wang , Chengjie Wang

While Vision-Language Models (VLMs) have achieved notable progress in computational pathology (CPath), the gigapixel scale and spatial heterogeneity of Whole Slide Images (WSIs) continue to pose challenges for multimodal understanding.…

计算机视觉与模式识别 · 计算机科学 2025-12-22 Fengchun Liu , Songhan Jiang , Linghan Cai , Ziyue Wang , Yongbing Zhang

Deep learning models have shown immense promise in computational pathology (CPath) tasks, but their performance often suffers when applied to unseen data due to domain shifts. Addressing this requires domain generalization (DG) algorithms.…

计算机视觉与模式识别 · 计算机科学 2025-11-12 Neda Zamanitajeddin , Mostafa Jahanifar , Kesi Xu , Fouzia Siraj , Nasir Rajpoot

Visual Grounding, also known as Referring Expression Comprehension and Phrase Grounding, aims to ground the specific region(s) within the image(s) based on the given expression text. This task simulates the common referential relationships…

计算机视觉与模式识别 · 计算机科学 2025-11-12 Linhui Xiao , Xiaoshan Yang , Xiangyuan Lan , Yaowei Wang , Changsheng Xu

Visual grounding is a common vision task that involves grounding descriptive sentences to the corresponding regions of an image. Most existing methods use independent image-text encoding and apply complex hand-crafted modules or…

计算机视觉与模式识别 · 计算机科学 2024-10-29 Ming Dai , Lingfeng Yang , Yihao Xu , Zhenhua Feng , Wankou Yang