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Droplet microfluidics offers a versatile platform for analyzing liquid samples. Despite its potential, there is a lack of techniques that allow to reliably probe individual circulating droplets. The prospect of combining droplet…

定量方法 · 定量生物学 2024-03-08 Marc Sulliger , Jaime Ortega Arroyo , Romain Quidant

Ultrasound-vaporizable microdroplets can be exploited for targeted drug delivery. However, it requires customized microfluidic techniques able to produce monodisperse, capillary-sized and biocompatible multiple emulsions. Recent development…

软凝聚态物质 · 物理学 2019-12-17 E. Teston , V. Hingot , V. Faugeras , C. Errico , M. Bezagu , M. Tanter , O. Couture

Droplet microlasers, as promising tools for biophotonics and biomedical sciences, have witnessed rapid advances due to their flexible reconfigurability, high sensitivity to stimuli, and label-free biosensing ability. However, designing…

The combination of microfluidic technology and optical fluids characterization techniques has been recently applied to produce lab-on-a-chip systems. In the present work, bringing together the imaging technique called photoacoustic imaging…

Cellular metabolic rate is a good indicator of the physiological state of cells and its changes, which can be measured by total heat flux accompanying metabolism. Chip calorimeters can provide label-free and high throughput measurements of…

生物物理 · 物理学 2019-03-13 Jihye Kim , Sumin Seo , Jonghyun Kim , Sungmin Nam , Wonhee Lee

Cell spheroids are in vitro multicellular model systems that mimic the crowded micro-environment of biological tissues. Their mechanical characterization can provide valuable insights in how single-cell mechanics and cell-cell interactions…

定量方法 · 定量生物学 2022-11-21 R. C. Boot , A. Roscani , L. van Buren , S. Maity , G. H. Koenderink , P. E. Boukany

Flexible photonics offers the possibility to realize wearable sensors by bridging the advantages of flexible materials and photonic sensing elements. Recently, optical resonators have emerged as a tool to improve its over sensitivity by…

光学 · 物理学 2023-12-22 Ningyuan Nie , Yu-Cheng Chen

Islet microencapsulation is a promising solution to diabetes treatment, but its quality control based on manual microscopic inspection is extremely low-throughput, highly variable and laborious. This study presents a high-throughput…

仪器与探测器 · 物理学 2018-12-31 Yibo Zhang , Michael Alexander , Sam Yang , Yinxu Bian , Elliot Botvinick , Jonathan R. T. Lakey , Aydogan Ozcan

Microfluidic droplet screens serve as an innovative platform for high-throughput biotechnology, enabling significant advancements in discovery, product optimization, and analysis. This review sheds light on the emerging trend of interaction…

定量方法 · 定量生物学 2023-09-11 Carolus Vitalis , Tobias Wenzel

Curable hydrogels have tunable properties that make them well-suited for applications in drug delivery, cell therapies, and 3D bioprinting. Advances in microfluidic droplet generation enable rapid fabrication of polymer-filled droplets.…

流体动力学 · 物理学 2025-12-02 Sabrina Marnoto , Avi J. Patel , Sara M. Hashmi

Detection and identification of lipids are highly coveted for the interrogation of chronic diseases such as atherosclerosis and myocardial infarction. Intravascular photoacoustic imaging (IVPA) and deep tissue imaging are modern techniques,…

Studies of biological solutions require high measurement accuracy, the ability to detect low changes in substance concentration, and small amounts of the liquid under test. A microwave complex permittivity measurement technique based on a…

Microfluidic technology has emerged as a powerful tool for studying complex biological processes with enhanced precision and control. A microfluidic chip was designed to emulate human-like microvascular networks with precise control over…

生物物理 · 物理学 2025-02-18 Shobhit Das , Shilpi Pandey , Oliver Hayden

Size and shape are critical discriminators between molecular species and states. We describe a micro-chip based high-throughput imaging approach offering rapid and precise determination of molecular properties under native solution…

Effective mixing is essential for biochemical reactions. In droplet-based microfluidics, immediate mixing of substances upon contact in the droplet formation stage can greatly enhance the uniformity of chemical reactions. Furthermore, it…

流体动力学 · 物理学 2024-01-17 Ali Kheirkhah Barzoki , Alireza Mohseni , Mohammad Mehdi Bazyar , Kaivan Mohammadi

High throughput screening of small molecules and natural products is costly, requiring significant amounts of time, reagents, and operating space. Although microarrays have proven effective in the miniaturization of screening for certain…

This work describes a new microfluidic device developed for rapid screening of solubility diagrams. In several parallel channels, hundreds of nanoliter-volume droplets of a given solution are first stored with a gradual variation in the…

软凝聚态物质 · 物理学 2007-05-23 P. Laval , N. Lisai , J. -B. Salmon , M. Joanicot

Infrared (IR) imaging has become a viable tool for visualizing various chemical bonds in a specimen. The performance, however, is limited in terms of spatial resolution and imaging speed. Here, instead of measuring the loss of the IR beam,…

光学 · 物理学 2018-11-20 Yeran Bai , Delong Zhang , Lu Lan , Yimin Huang , Kerry Maize , Ali Shakouri , Ji-Xin Cheng

Biophotonics - and more recently, biointegrated photonics - offer transformative tools for probing cellular processes with unprecedented precision. Among these, whispering gallery mode (WGM) resonators - optical microcavities formed in…

Rapid identification of microparticles in liquid is an important problem in environmental and biomedical applications such as for microplastic detection in water sources and physiological fluids. Existing spectro-scopic techniques are…

应用物理 · 物理学 2024-11-20 Yagmur Ceren Alatas , Uzay Tefek , Sayedus Salehin , Hashim Alhmoud , M. Selim Hanay
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