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Without knowledge of specific pockets, generating ligands based on the global structure of a protein target plays a crucial role in drug discovery as it helps reduce the search space for potential drug-like candidates in the pipeline.…

生物大分子 · 定量生物学 2023-10-02 Nhat Khang Ngo , Truong Son Hy

Reliable fault detection is an essential requirement for safe and efficient operation of complex mechanical systems in various industrial applications. Despite the abundance of existing approaches and the maturity of the fault detection…

信号处理 · 电气工程与系统科学 2024-08-19 Tianfu Li , Chuang Sun , Ruqiang Yan , Xuefeng Chen

Variational Autoencoder (VAE) and its variations are classic generative models by learning a low-dimensional latent representation to satisfy some prior distribution (e.g., Gaussian distribution). Their advantages over GAN are that they can…

计算机视觉与模式识别 · 计算机科学 2020-09-24 Cong Geng , Jia Wang , Li Chen , Zhiyong Gao

In recent years, deep learning based generative models, particularly Generative Adversarial Networks (GANs), Variational Autoencoders (VAEs), and Diffusion Models (DMs), have been instrumental in in generating diverse, high-quality content…

计算机视觉与模式识别 · 计算机科学 2025-10-28 Shamim Yazdani , Akansha Singh , Nripsuta Saxena , Zichong Wang , Avash Palikhe , Deng Pan , Umapada Pal , Jie Yang , Wenbin Zhang

A large part of the literature on learning disentangled representations focuses on variational autoencoders (VAE). Recent developments demonstrate that disentanglement cannot be obtained in a fully unsupervised setting without inductive…

机器学习 · 计算机科学 2021-02-11 Graziano Mita , Maurizio Filippone , Pietro Michiardi

The Variational Autoencoder (VAE) is known to suffer from the phenomenon of \textit{posterior collapse}, where the latent representations generated by the model become independent of the inputs. This leads to degenerated representations of…

机器学习 · 计算机科学 2023-09-12 Fotios Lygerakis , Elmar Rueckert

Variational Autoencoders (VAEs) are a powerful framework for learning latent representations of reduced dimensionality, while Neural ODEs excel in learning transient system dynamics. This work combines the strengths of both to generate fast…

机器学习 · 计算机科学 2025-02-27 Julius Aka , Johannes Brunnemann , Jörg Eiden , Arne Speerforck , Lars Mikelsons

Integrated artificial intelligence (AI) and communication has been recognized as a key pillar of 6G and beyond networks. In line with AI-native 6G vision, explainability and robustness in AI-driven systems are critical for establishing…

信号处理 · 电气工程与系统科学 2025-01-31 Nasir Khan , Asmaa Abdallah , Abdulkadir Celik , Ahmed M. Eltawil , Sinem Coleri

Building on the success of deep learning, Generative Adversarial Networks (GANs) provide a modern approach to learn a probability distribution from observed samples. GANs are often formulated as a zero-sum game between two sets of…

机器学习 · 计算机科学 2020-09-28 Pirazh Khorramshahi , Hossein Souri , Rama Chellappa , Soheil Feizi

Generative modeling of 3D brain MRIs presents difficulties in achieving high visual fidelity while ensuring sufficient coverage of the data distribution. In this work, we propose to address this challenge with composable, multiscale…

图像与视频处理 · 电气工程与系统科学 2023-01-12 Jaivardhan Kapoor , Jakob H. Macke , Christian F. Baumgartner

Deep generative models are a class of techniques that train deep neural networks to model the distribution of training samples. Research has fragmented into various interconnected approaches, each of which make trade-offs including…

机器学习 · 计算机科学 2022-03-29 Sam Bond-Taylor , Adam Leach , Yang Long , Chris G. Willcocks

Variational Autoencoders (VAE) are probabilistic deep generative models underpinned by elegant theory, stable training processes, and meaningful manifold representations. However, they produce blurry images due to a lack of explicit…

计算机视觉与模式识别 · 计算机科学 2019-11-15 Prashnna K Gyawali , Rudra Saha , Linwei Wang , VSR Veeravasarapu , Maneesh Singh

In spite of remarkable progress in deep latent variable generative modeling, training still remains a challenge due to a combination of optimization and generalization issues. In practice, a combination of heuristic algorithms (such as…

机器学习 · 统计学 2018-10-02 Danilo Jimenez Rezende , Fabio Viola

Systematic characterization of biological effects to genetic perturbation is essential to the application of molecular biology and biomedicine. However, the experimental exhaustion of genetic perturbations on the genome-wide scale is…

With the mass construction of Gen III nuclear reactors, it is a popular trend to use deep learning (DL) techniques for fast and effective diagnosis of possible accidents. To overcome the common problems of previous work in diagnosing…

信号处理 · 电气工程与系统科学 2022-09-26 Chengyuan Li , Zhifang Qiu , Zhangrui Yan , Meifu Li

Deep probabilistic generative models have achieved incredible success in many fields of application. Among such models, variational autoencoders (VAEs) have proved their ability in modeling a generative process by learning a latent…

机器学习 · 计算机科学 2022-12-16 Eleonora Grassucci , Danilo Comminiello , Aurelio Uncini

The variational autoencoder (VAE) is a simple and efficient generative artificial intelligence method for modeling complex probability distributions of various types of data, such as images and texts. However, it suffers some main…

机器学习 · 计算机科学 2025-02-14 Xi Chen , Shaofan Li

Predicting how genetic perturbations change cellular state is a core problem for building controllable models of gene regulation. Perturbations targeting the same gene can produce different transcriptional responses depending on their…

基因组学 · 定量生物学 2026-02-12 Boyang Fu , George Dasoulas , Sameer Gabbita , Xiang Lin , Shanghua Gao , Xiaorui Su , Soumya Ghosh , Marinka Zitnik

We present a new category of physics-informed neural networks called physics informed variational embedding generative adversarial network (PI-VEGAN), that effectively tackles the forward, inverse, and mixed problems of stochastic…

机器学习 · 计算机科学 2023-07-24 Ruisong Gao , Yufeng Wang , Min Yang , Chuanjun Chen

With the introduction of the variational autoencoder (VAE), probabilistic latent variable models have received renewed attention as powerful generative models. However, their performance in terms of test likelihood and quality of generated…

机器学习 · 统计学 2020-01-13 Lars Maaløe , Marco Fraccaro , Valentin Liévin , Ole Winther
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